Accumulation of NCC-CO-411 Monoclonal Antibody in Human Colorectal Adenocarcinoma through Binding of the Released Carcinoembryonic Antigen in Nude Mice

スポンサーリンク

概要

• 論文の詳細を見る

• NCC-CO-411,an anti-carcinoembryonic antigen (CEA) monoclonal antibody (MoAb) showed a dose-dependent reactivity with standard CEA, but did not bind to the CEA anchoring with cell membranes. When LS 174T cells, one of the CEA-producing cells, were treated with phosphatidylinositol-specific phospholipase C, NCC-CO-411 MoAb recognized the released CEA containing glycosylphosphatidylinositol as well as the standard CEA. The binding activity of NCC-CO-411 MoAb with CEA was also demonstrated by the immunostaining of the LS 174T colorectal tumor xenograft tissues. The biodistribution study showed that NCC-CO-411 MoAb was mainly taken up by tumor and kidney, while the anti-hCEA MoAb was largely concentrated in liver and spleen rather than in the tumor. These results suggest that NCC-CO-411 MoAb recognizes the released CEA and gives an excellent tumor image in LS 174T tumor-bearing mice.

• 公益社団法人日本薬学会の論文
• 1996-07-15

著者

• KOJIMA Shuji

  Research Institute for Biological Sciences, Science Univ. of Tokyo

• Kojima Shigeo

  National Institute Of Health Sciences

• Kojima S

  National Institute Of Health Sciences

• Ueno Yukihiro

  Department Of Microbiology Tohoku Pharmceutical University

• Wang Dian-sheng

  Research Institute For Biosciences Science University Of Tokyo:faculty Of Pharmaceutical Sciences Sc

• UENO Yosio

  Research Institute for Biosciences, Science University of Tokyo

• OYAMADA Hiyoshimaru

  Japanese Foundation for Cencer Research

• Oyamada H

  Japanese Foundation For Cancer Research

• OYAMADA Hiyoshimaru

  Japanese Foundation for Cancer Research

関連論文

• Effect of Propranolol on Hyphae Formation Signal in Candida albicans(Microbiology)
• Suppression of Diabetes by Low Dose γ-Ray Irradiation in Nonobese (NOD) Mice
• Induction of Glutathione in Mouse Brain by Low Doses of γ-Rays and Its Applicability to Protection and Therapy against Brain Diseases
• Effect of Small Doses of γ-Ray on the Glutathione Level in Mouse Organs.
• Does Small-Dose γ-Ray Radiation Induce Endogenous Antioxidant Potential in Vivo?
• Abnormal Dissolutions of Chlorpromazine Hydrochloride Tablets in Water by Paddle Method under a High Agitation Condition
• Mass Variation Tests for Coating Tablets and Hard Capsules : Rational Application of Mass Variation Tests
• The Study of the Applicability of Content Uniformity and Weight Variation Test : The State of Commercial Tablets and Capsules in Japan
• Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies
• Effects of Atropine and Loperamide on the Agitating Force and GI Transit Time in Dogs in Drug Absorption Studies
• Role of Ca^/Calmodulin Signaling Pathway on Morphological Development of Candida albicans(Miscellaneous)
• Pharmacognostical Studies of Cistanchis Herba (IV) Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Region Sequence
• Pharmacognostical Studies of Cistanchis Herba(III)Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Sequences
• Hyphae Formation of Candida albicans Is Regulated by Polyamines(Miscellaneous)
• Molecular Mobility of Lyophilized Poly(vinylpyrrolidone) and Methylcellulose as Determined by the Laboratory and Rotating Frame Spin-Lattice Relaxation Times of ^1H and ^C
• A Comparison of the Analysis of Covariance (ANCOVA) and Range-Based Approaches for Assessing Batch-to-Batch Variability of the Stability of Pharmaceutical Products
• Effect of Polymer Excipients on the Enzyme Activity of Lyophilized Bilirubin Oxidase and β-Galactosidase Formulations
• Solid-State Rehydration-Induced Recovery of Bilirubin Oxidase Activity in Lyophilized Formulations Reduced during Freeze-Drying
• Assessment of Shelf-Life Equivalence of Pharmaceutical Products
• Power of Analysis of Variance for Assessing Batch-Variation of Stability Data of Pharmaceuticals
• Relationship between Water Mobility, Measured as Nuclear Magnetic Relaxation Time, and the Crystallization Rate of Amorphous Nifedipine in the Presence of Some Pharmaceutical Excipients
• Determination of the Diffusion Coefficient of Insulin and Lysozyme in Crosslinked Dextran Hydrogels by Pulsed-Field-Gradient NMR
• Effect of 5,6,7,8 : Tetrahydroneopterin on Oxidative Modification of Low : Density Lipoprotein, and Its Uptake in the Macrophage : Like Cell Line J774
• Assessment of Gastric Acidity of Japanese Subjects over the Last 15 Years
• Accumulation of NCC-CO-411 Monoclonal Antibody in Human Colorectal Adenocarcinoma through Binding of the Released Carcinoembryonic Antigen in Nude Mice
• Enhancement of the Antitumor Effect of γ-Ray Irradiation in Combination with Camptothecin against Human Colorectal Adenocarcinoma
• Protection of Protein Secondary Structure by Saccharides of Different Molecular Weights during Freeze-Drying
• Effect of Sodium Tetraborate (Borax) on the Thermal Properties of Frozen Aqueous Sugar and Polyol Solutions
• Effect of 5, 6, 7, 8-Tetrahydroneopterin on the Bovine Endothelial Cell Injury Induced by cumene Hyduoperoxide
• PREPARATION AND CHARACTERIZATION OF NEOGLYCOPROTEIN-CONJUGATED LIPOSOMES
• Pharmacognostical Studies of Cistanchis Herba (IV) Phylogenetic Relationship of the Cistanche Plants Based on Plastid rps2 Gene and rpl16-rpl14 Intergenic Spacer Region Sequence

もっと見る 閉じる

スポンサーリンク