Enhancement of the Antitumor Effect of γ-Ray Irradiation in Combination with Camptothecin against Human Colorectal Adenocarcinoma
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概要
- 論文の詳細を見る
The effect of γ-ray irradiation and camptothecin (CAM) on human colorectal adenocarcinoma (LS 174T) growth was examined. On inhibition of DNA synthesis of LS 174T cells, almost all combined treatments presented a synergistic effect, excepting that the additive effects were shown at the lowest or the highest doses of CAM prior to the γ-ray (^<137>Cs) irradiation. The in vivo antitumor activity of ^<131>I-NCC-CO-411 monoclonal antibody against carcinoembryonic antigen in combination with CAM was assessed by a tumor growth rate in LS 174T tumor-bearing nude mice. The tumor growth of the combined group was supra-additively suppressed in comparison with that of the individual group. The results suggest that the efficacy of radioimmunotherapy may be enhanced by combination treatment with CAM. A clinical protocol involving a combination treatment with CAM is underway.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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KOJIMA Shuji
Research Institute for Biological Sciences, Science Univ. of Tokyo
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Kojima Shigeo
National Institute Of Health Sciences
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Kojima S
National Institute Of Health Sciences
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Ueno Yukihiro
Department Of Microbiology Tohoku Pharmceutical University
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Wang Dian-sheng
Research Institute For Biosciences Science University Of Tokyo:faculty Of Pharmaceutical Sciences Sc
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OYAMADA Hiyoshimaru
Japanese Foundation for Cencer Research
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UENO Yoshio
Research Institute for Biosciences, Science University of Tokyo
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Oyamada H
Japanese Foundation For Cancer Research
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Ueno Yoshio
Research Institute For Biosciences Science University Of Tokyo
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Ueno Yoshio
Research Institute For Biosciences And Department Of Toxicology And Microbial Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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OYAMADA Hiyoshimaru
Japanese Foundation for Cancer Research
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