Reactivity of 12,13-Epoxytrichothecenes with Epoxide Hydrolase, Glutathione-S-Transferase and Glutathione
スポンサーリンク
概要
- 論文の詳細を見る
Interaction of the 12,13-epoxytrichothecenes and related mycotoxins with epoxide hydrolase and glutathione-S-transferase (GSH-S-transferase) from rat liver was examined in vitro. Neither hydrolysis of safrole oxide by the microsomal epoxide hydrolase nor conjugation of 2,3-epoxy-(p-nitrophenoxy) propane with GSH by the soluble GSH-S-transferase was interfered with the trichothecenes such as T-2 toxin and fusarenon-X. Gas-liquid chromatography (GLC) analysis and colorimetric determination of the residual GSH revealed that the trichothecenes were inert to the partially purified GSH-S-transferase. In contrast to the trichothecenes, PR-toxin, an epoxide mycotoxin from Penicillium roqueforti, and lactones such as patulin and penicillic acid from Penicillium and Aspergillus spp., were found to react non-enzymatically with GSH in molar ratio of 1 : 1.
- 社団法人日本薬学会の論文
- 1977-12-25
著者
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太田 稔
Tokyo College Of Pharmacy
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上野 芳夫
Research Institute For Biosciences Science University Of Tokyo:department Of Toxicology And Microbia
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上野 芳夫
Department Of Toxicology And Microbial Chemistry Faculty Of Pharmaceutical Sciences University Of To
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中村 泰子
Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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太田 稔
Department of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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中村 泰子
Department Of Microbial Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Ueno Yoshio
Research Institute For Biosciences Science University Of Tokyo
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