Microbial Assay of Hepatotoxic Anthraquinones with Escherichia coli F-11
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概要
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In order to find out the method for a biological detection of luteoskyrin, a hepatotoxic anthraquinone of Penicillium islandicum Sopp, we investigated the inhibitory effect of mycotoxins on the growth rate of Escherichia coli F-11 and Q-13. The results were summerized as follows ; 1) 0.4 μg/ml of (-)-luteoskyrin or 1.5 μg/ml of (+)-rugulosin, hepatotoxic anthra-quinoes of Penicillium islandicum Sopp or Penicillium rugulosum, caused the 50% inhibition of the growth of E. coli F-11,an actinomycin D sensitive mutant derived from E. coli Q-13,without affecting the parent type. 2) 2-5 μg/ml of patulin, (-)-rugulosin and penicillic acid inhibited the both bacteria. 3) Sporidesmin, flavoskyrin, catenarin and emodin inhibited slightly E. coli F-11. 4) No inhibition was observed with chlorine-containing peptide, islandicin, ascradiol, nivalenol, fusarenon-X, rubratoxin B, aflatoxin B or citrinin. 5) E. coli F-11 is considered to be a simple tool for the microbial assay of the hepatotoxic luteoskyrin or rugulosin contaminated in fungi-polluted cereal grains or foodstuffs.
- 社団法人日本薬学会の論文
- 1970-01-25
著者
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上野 芳夫
Research Institute For Biosciences Science University Of Tokyo:department Of Toxicology And Microbia
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上野 芳夫
Laboratory of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Sciences
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山川 洋志
Laboratory of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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山川 洋志
Laboratory Of Microbial Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Ueno Yoshio
Research Institute For Biosciences Science University Of Tokyo
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