Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies
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概要
- 論文の詳細を見る
Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
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Nishio Kazuto
Shien-laboratory National Cancer Center Hospital
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Aoyagi Nobuo
National Institute Of Health Sciences
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Aoyagi Nobuo
国立医薬品食品衛生研究所
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Aoyagi N
National Institute Of Health Sciences
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Kojima Shigeo
National Institute Of Health Sciences
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KATORI Noriko
National Institute of Health Sciences
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Kojima S
National Institute Of Health Sciences
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Katori N
National Cancer Center
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