Effect of Sho-saiko-to Extract on Hepatic Inflammation and Fibrosis in Dimethylnitrosamine Induced Liver Injury Rats
スポンサーリンク
概要
- 論文の詳細を見る
Sho-saiko-to extract, a Chinese herbal medicine, is widely used for treatment of chronic hepatitis in Japan. However, it is not clear what conditions Sho-saiko-to extract improves hepatic inflammation and fibrosis. We therefore induced various stages of liver injury in model rats and administered Sho-saiko-to extract. We then evaluated the liver inflammation and liver fibrosis-improving effects of Sho-saiko-to extract. The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats. Then the liver inflammation and fibrosis-improving effects of Sho-saiko-to extract were evaluated according to L-asparate aminotransferase (AST), L-alanine aminotransferase (ALT), liver retinoid levels, levels of hydroxyproline, Transforming Growth Factor-β (TGF-β), and the liver fibrosis area. These indicators depended on the total doses of DMN. The ability of Sho-saiko-to extract to improve liver inflammation and fibrosis was limited to the following levels of the respective parameters: AST levels (234-264 U/l), ALT levels (208-232 U/l), TGF-β levels (1102-1265 pg/g liver tissue), hydroxyproline levels (633-719 nmol/g liver tissue), and liver fibrosis area (9.7-10.6 times for normal rat). These findings suggested that Sho-saiko-to extract is effective in the treatment of liver inflammation and fibrosis up to a certain degree of severity, but it produces no improvement in more severe cases.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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YOSHIOKA Saburo
Department of Pharmacy, Kochi Medical School Hospital
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MIYAMURA Mitsuhiko
Department of Pharmacy, Kochi Medical School Hospital
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KYOTANI Shojiro
Faculty of Pharmaceutical Sciences Tokushima Bunri University
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CUI Tailin
Department of Medicine, School of Medicine, Kitasato University
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NISHIOKA YUTAKA
Department of Surgery, Kochi Municipal Central Hospital
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Yoshioka Saburo
Department Of Pharmacy Kochi Medical School Hospital
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Yoshioka Saburo
Department Of Pharmacy Kochi Medical School
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Miyamura Mitsuhiko
Department Of Pharmacy Kochi Medical School Hospital
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Cui Tailin
Department Of Pharmacy Kochi Medical School Hospital
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Cui Tailin
Department Of Medicine School Of Medicine Kitasato University
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HAMADA Atsuhide
Department of Pharmacy, Kochi Medical School Hospital
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KUSUNOSE Masahiko
Department of Pharmacy, Kochi Medical School Hospital
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KYOTANI Shojiro
Department of Pharmacy, Kochi Medical School Hospital
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Qiu Bing
Department of Pharmacy Kochi Medical School Hospital
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ONO Masahide
Department of Pharmacy Kochi Medical School Hospital
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Ono Masahide
Department Of Biomedical Science Kochi Medical Graduate School
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Hamada Atsuhide
Department Of Pharmacy Kochi Medical School Hospital
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Nishioka Y
Department Of Biomedical Science Kochi Medical Graduate School
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Nishioka Yutaka
Department Of Pharmacy Kochi Medical School
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Kusunose M
Department Of Pharmacy Kochi Medical School Hospital
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Kusunose Masahiko
Department Of Information Science Faculty Of Science Kochiuniversity
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