Preparation and Clinical Evaluation of Streptokinase Jelly for Intractable Decubitus and Skin Ulcer

スポンサーリンク

概要

• 論文の詳細を見る

• For the purpose of treating intractable decubitus and skin ulcer, streptokinase (SK) jellies containing different types of thickening agents were prepared. Adhesion to the affected sites, the spreading ability of the jelly preparation, and the properties of the SK in the jelly, which are all considered to greatly affect the clinical efficacy, were examined pharmaceutically using the viscosity, spreading area, and release and stability of SK as indexes. Regarding the viscosity and spreading area which are thought to affect both adhesion and spreading greatly, when sodium polyacrylate (Papa) was used as a thickener, higher viscosity and smaller spreading area were obtained in comparison with carboxymethylcellulose sodium (CMCNa) and sodiunl alginate (Alg Na). In addition. the viscosity and the spreading area obtained with Papa were also slightly more affected by temperature than with CMCNa and AlgNa. Regarding the release of SK from the jelly preparations. with Papa no initial burst was observed and SK was continuously released at a constant rate in contrast with CMCNa and AlgNa, thus obviously showing the superiority of Papa in the retention of SK. Although no loss of the potency of SK was found in the jellies containing Papa. CMCNa or AlgNa at 5℃, for 30 days, the remaining potency was greatly decreased to 49-62% at 25℃ after 30 days and 33-42%at 37℃ after 30 days. These results showed that the adhesion, spreading ability and SK-release were greatly different among the tested thickening agents, and the properties of Papa were found to be clearly superior to those of the other agents. According to these results. SK jelly containing 2% Papa was used for the treatment of intractable decubitus and skin ulcer, and an excellent therapeutic effect was obtained.

• 日本医療薬学会の論文
• 1997-12-10

著者

• YOSHIOKA Saburo

  Department of Pharmacy, Kochi Medical School Hospital

• MIYAMURA Mitsuhiko

  Department of Pharmacy, Kochi Medical School Hospital

• KYOTANI Shojiro

  Faculty of Pharmaceutical Sciences Tokushima Bunri University

• Kodama Hajime

  Department Of Dermatology Kochi Medical School

• Yamamoto Yasuo

  Department Of Chemistry College Of Science Rikkyo University

• OGATA Kimiko

  Department of Dermatology, Kochi Medical School

• IKEDA Mitsunori

  Department of Dermatology, Kochi Medical School

• NISHIOKA YUTAKA

  Department of Surgery, Kochi Municipal Central Hospital

• Yoshioka Saburo

  Department Of Pharmacy Kochi Medical School Hospital

• Yoshioka Saburo

  Department Of Pharmacy Kochi Medical School

• Miyamura Mitsuhiko

  Department Of Pharmacy Kochi Medical School Hospital

• Ogata Kimiko

  Department Of Dermatology Kochi Medical School

• KYOTANI Shojiro

  Department of Pharmacy, Kochi Medical School Hospital

• Odani Kazuhiro

  Muroto Marinefood Corporation

• Nishioka Y

  Department Of Biomedical Science Kochi Medical Graduate School

• Nishioka Yutaka

  Department Of Pharmacy Kochi Medical School

• Kodama Hajime

  Department Of Dermatology Kochi Medical School Kochi University

• Ikeda Mitsunori

  Department Of Dermatology Kochi Medical School Kochi University

• Ikeda Mitsunori

  Department Of Biochemistry Kawasaki Medical School

• Odani K

  Muroto Marinefood Corp. Kochi Jpn

• Yamamoto Yasuo

  Department Of Dermatology Kochi Medical School

関連論文

• Immunomodulatory Effect of Eriobotrya japonica Seed Extract on Allergic Dermatitis Rats
• Monomeric 10-Sb-5 Pentacoordinate Organoantimony Monohalides and Their Permutational Behavior
• Synthesis, Structure, and Reactions of 10-Sn-5 Organotin Ate Complexes
• Community validation of the U.K. diagnostic criteria for atopic dermatitis in Japanese elementary schoolchildren
• Synthesis, Structure, and Reactions of a 10-Sb-4 Type Antimony Ate Complex
• Erythema multiforme after radiotherapy with aromatase inhibitor administration in breast-conservation treatment for breast cancer
• Adult-onset herpes simplex virus hepatitis with diffuse myofibroblastic transformation of hepatic stellate cells(lto cells)in non-necrotic areas
• IgG/IgA pemphigus with dyskeratotic acantholysis and intraepidermal neutrophilic microabscesses
• Xanthoma tissue-extracted LDL density substances are the main inducer of myelin-like bodies and ceroid granules in foam cells
• Contribution of xanthoma tissue-derived LDL density substances in the transformation of macrophages to foam cells
• Spindle Cell Squamous Cell Carcinoma Showing Continuous Mesenchymal Dedifferentiation in a Single Tumor
• Antisense phosphorothioate oligonucleotides to NF-κB (RelA/NF-κB1) decrease interleukin-8 secretion from cultured normal human epidermal keratinocytes
• Large Annular Purpura and Paraneoplastic Purpura in a Patient with Sjogren's Syndrome and Cervical Cancer
• Erythema Elevatum Diutinum Complicated by Rheumatoid Arthritis
• Aggressive surgery for liver metastases from gastrointestinal stromal tumors
• Stabilized Self-Sustained Sequence Replication against Evolutionary Instability
• Psoriasis Associated with Behcet's Disease
• "Miocene calcareous nannofossils of the Bihoku group in the Shobara area, Hiroshima prefecture, southwest Japan"
• The Effect of Eriobotrya japonica Seed Extract on Oxidative Stress in Adriamycin-Induced Nephropathy in Rats(Pharmacognosy)
• Pharmacological Activity of Deep-Sea Water: Examination of Hyperlipemia Prevention and Medical Treatment Effect(Pharmacology)
• Effect of Sho-saiko-to Extract on Hepatic Inflammation and Fibrosis in Dimethylnitrosamine Induced Liver Injury Rats
• Effects of Extract Derived from Eriobotrya japonica on Liver Function Improvement in Rats
• Molecular Mobility of Lyophilized Poly(vinylpyrrolidone) and Methylcellulose as Determined by the Laboratory and Rotating Frame Spin-Lattice Relaxation Times of ^1H and ^C
• A Comparison of the Analysis of Covariance (ANCOVA) and Range-Based Approaches for Assessing Batch-to-Batch Variability of the Stability of Pharmaceutical Products
• Effect of Polymer Excipients on the Enzyme Activity of Lyophilized Bilirubin Oxidase and β-Galactosidase Formulations
• Solid-State Rehydration-Induced Recovery of Bilirubin Oxidase Activity in Lyophilized Formulations Reduced during Freeze-Drying
• Assessment of Shelf-Life Equivalence of Pharmaceutical Products
• Power of Analysis of Variance for Assessing Batch-Variation of Stability Data of Pharmaceuticals
• Relationship between Water Mobility, Measured as Nuclear Magnetic Relaxation Time, and the Crystallization Rate of Amorphous Nifedipine in the Presence of Some Pharmaceutical Excipients
• Cutaneous botryomycosis associated with eosinophilic cellulitis
• Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma
• Transition of psoriasiform drug eruption to psoriasis de novo evidenced by histopathology
• Two cases of diabetic scleredema that responded to PUVA therapy
• Coexistence of nodular and dyshidrosiform pemphigoid
• Hyaluronan forms complexes with low density lipoprotein while also inducing foam cell infiltration in the dermis
• Discrete Papular Mucinosis on the Back
• Mucinous Nevus
• Different mechanisms of adhesion molecule expression in human dermal microvascular endothelial cells by xanthoma tissue-mediated and copper-mediated oxidized low density lipoproteins
• Coexistence of Riehl's Melanosis and Lichen Planus
• Low density lipoprotein oxidized in xanthoma tissue induces the formation and infiltration of foam cells
• Nuclear factor κB(NF-κB) activation by hydrogen peroxide in human epidermal keratinocytes and the restorative effect of interleukin-10
• Increased synthesis of calcitonin gene-related peptide stimulates keratinocyte proliferation in murine UVB-irradiated skin
• Characterization and Identification of a Steroid Receptor-Binding Protein, SRB-RGS(Molecular and Cell Biology)
• Gastroprotective activity of Eriobotrya japonica seed extract on experimentally induced gastric lesions in rats
• Effect of Eriobotrya japonica Seed Extract on 5-Fluorouracil-Induced Mucositis in Hamsters(Pharmacognosy)
• Scavenging of Reactive Oxygen Species by Eriobotrya japonica Seed Extract(Pharmacology)
• Difference between Deep Seawater and Surface Seawater in the Preventive Effect of Atherosclerosis(Pharmacology)
• Relationship between the Eosinophilia of Bronchoalveolar Lavage Fluid (BALF) and the Severity of Pulmonary Fibrosis Induced by Bleomycin in Rats
• Preparation and Clinical Evaluation of Streptokinase Jelly for Intractable Decubitus and Skin Ulcer
• Roles of SiH_3 and SiH_2 Radicals in Particle Growth in rf Silane Plasmas
• Effects of Dilution Gases on Si Atoms and SiHx^^+ (X = 0-3) Ions in Electron Cyclotron Resonance SiH_4 Plasmas
• Evaluation of aggressive surgical treatment for advanced carcinoma of the gallbladder
• Local Recurrence of Breast Cancer Demonstrated on ^Tc-MIBI Scintigraphy
• HI-Mediated Cyclization of o-Alkynylstyrenes
• Synthesis and Structure of a Germylene Bearing a 1, 8-Dimethoxyanthracene Ligand
• Synthesis of a New Tridentate Anthracene Ligand Bearing (i-Pr9_2P Group at 1,8-Positions: Facile Bond Switch on Tetracoordinate Boron Atom
• An Application of Liquid Chromatography/Mass Spectrometry to Determination of Fatty Acids with a Wide Range of Carbon Chain Lengths (C_-C_) in Mycobacteria
• A focused DNA microarray analysis of estrogen-responsive genes in COS-7 cells over-expressing the estrogen receptor α
• Structure of Intrinsic States of K^π=0^+ Bands in ^Ne : Study of Transient Character
• Histological distribution of FR-1, a cyclic RGDS-peptide, binding sites during early embryogenesis, and isolation and initial characterization of FR-1 receptor in the sand dollar embryo
• Synthesis of RGDFPASS-containing Cystine Peptides and Isolation of RGD-recognizing Receptor in Sand Dollar Embryo by the Peptide-Affinity Chromatography
• Structure and Activity of Fibronectin-related Peptides. The Role of Amino Acid Residues of Positions 5 and 6 in RGDSPASS-containing Cyclic Decapeptide(FR-1)
• The dansyl Group as a Molecular Probe for the Histochemical Localization of a Synthetic Fibronectin-related Peptide
• Design and Synthesis of Fibronectin-related Peptides. Ala-analogs of RGDSPASS Containing Cystine Peptide (FR-1)
• Design and Synthesis of Cyclic Fibronectin Related Peptides, RGDSPASS Containing Cystine Peptides
• Characterization of the functional domains and quantification in the cells of a steroid receptor-binding protein, SRB-RGS
• Erdheim-Chester Disease : Report of a Case with PCR-based Analysis of the Expression of Osteopontin and Survivin in Xanthogranulomas Following Glucocorticoid Treatment
• Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats
• Successful Treatment of Adolescent Pemphigus Vulgaris by Immunoadsorption Method
• Characterization of Peroxisomal Targeting Signals on Alanine : Glyoxylate Aminotransferase(Biochemistry)
• Palmar Erythema Ab Igne without Detectable Type IV Collagen at the Basement Membrane Zone
• Acute Form of Pyoderma Gangrenosum Induced by Traumatic Injury
• Disseminated Superficial Porokeratosis with Amyloid Deposition
• Epidemiological Analysis of Prognosis of 496 Japanese Patients with Progressive Systemic Sclerosis (SSc)
• Reaction Matrix Theory for Cluster States in Light Nuclei. II : Clustering Dependence of the Effective Interaction
• Reaction Matrix Theory for Cluster States in Light Nuclei. I : Be^8
• Estimation of Japanese Methotrexate Population Pharmacokinetic Parameters Calculated Using MULTI (ELS) Written in C-Language and a Personal Computer
• Application of Variational Principle with Natural Boundary Condition to Scattering in Generator Coordinate Method
• Synthesis of Fibronectin Related Peptides : N^α-Methyl Amino Acid-containing Peptides
• In vitro Adsorption of Paraquat onto Substituted Chitosan Beads
• Characterization of DNA-binding of the Rat Uterine Estrogen Receptor
• Ameliorative effects of Eriobotrya japonica seed extract on cellular aging in cultured rat fibroblasts
• Eriobotrya japonica seed extract and deep sea water protect against indomethacin-induced gastric mucosal injury in rats
• Molecular mechanisms of angiogenesis in non-small cell lung cancer, and therapeutics targeting related molecules
• Realistic Effective Interaction between Nucleons in Cluster State of Light Nuclei : Starting-Energy-Dependent Interaction and Its Application to Alpha-Cluster plus ^O-Core Model of ^Ne
• Riehl's Melanosis-like Eruption Associated with Sjogren's Syndrome
• Mucinous Cystadenocarcinoma Initially Diagnosed as Recurrent Infected Pancreatic Pseudocyst After Acute Pancreatitis : Report of a Case
• Bacteriological analysis of bile in acute cholecystitis according to the Tokyo guidelines
• Metabolomics Study on the Biochemical Profiles of Odor Elements in Urine of Human with Bladder Cancer
• Roles of SiH3 and SiH2 Radicals in Particle Growth in rf Silane Plasmas
• Papuloerythematous Rash Due to Intralymphatic Cutaneous Metastasis of Cancer
• The color isomerism of oxovanadium(IV) complexes with tetradentate schiff base.
• The nucleophilic substitution of dicarboxylic imides on the chelate ring of tris(3-bromo-2,4-pentanedionato)iron(III).
• A kinetic study of the reactions of several cobalt(III) complexes with ascorbic acid.
• The preparation and some properties of cobalt(II) Schiff base complexes and their molecular oxygen adducts.
• The preparation and some properties of 3-substituted 2,4-pentanedionato metal(II, III) complexes.
• Preparation and Properties of Dimeric Dialkoxo-bridged Chromium(III) Complexes with 3-Bromo-2,4-pentanedione
• The reduction of cobalt(III) complexes by ascorbic acid. II. The kinetics and mechanisms of the reactions of diaqua and aquahydroxo macrocyclic N4 complexes.
• A kinetic study of the anation reactions of some cobalt(III) complexes containing macrocyclic quadridentate amine ligands.
• Changes in the therapeutic strategy for acute cholecystitis after the Tokyo guidelines were published

もっと見る 閉じる

スポンサーリンク