Physical Stability of Amorphous Acetanilide Derivatives Improved by Polymer Excipients
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概要
- 論文の詳細を見る
Crystallization rates of drug-polymer solid dispersions prepared with acetaminophen (ACA) and p-aminoacetanilide (AAA) as model drugs, and polyvinylpyrrolidone and polyacrylic acid (PAA) as model polymers were measured in order to further examine the significance of drug-polymer interactions. The crystallization of AAA and ACA was inhibited by mixing those polymers. The most effective inhibition was observed with solid dispersions of AAA and PAA. The combination of AAA and PAA showed a markedly longer enthalpy relaxation time relative to drug alone as well as a higher T_g than predicted by the Gordon-Taylor equation, indicating the existence of a strong interaction between the two components. These observations suggest that crystallization is effectively inhibited by combinations of drug and polymer that show a strong intermolecular interaction due to proton transfer between acidic and basic functional groups.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
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MIYAZAKI Tamaki
National Institute of Health Sciences
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Yoshioka Sumie
National Institute Of Health Sciences
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Yoshioka Sumie
Division Of Drugs National Institute Of Health Sciences
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ASO Yukio
National Institute of Health Sciences
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MIYAZAKI Tamaki
Division of Drugs, National Institute of Health Sciences
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ASO Yukio
Division of Drugs, National Institute of Health Sciences
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Aso Yukio
Division Of Drugs National Institute Of Health Sciences
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