Swelling Behavior and Drug Release of Amphiphilic N-Isopropylacrylamide Terpolymer Xerogels Depending on Polymerization Methods : γ-Irradiation Polymerization and Redox Initiated Polymerization

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概要

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• Amphiphilic terpolymer xerogels were prepared from N-isopropyl acrylamide, acrylic acid, and n-dodecyl acrylamide by both chemical redox initiated polymerization and γ-irradiation polymerization. The swelling equilibrium and swelling kinetics of amphiphilic xerogels prepared by these two polymerization methods were compared. Drug release behavior was also compared using 5-fluorouracil (5-FU) as a model drug, in order to elucidate the effect of polymerization method. γ-Irradiation polymerization provided amphiphilic terpolymer xerogels which exhibited slower swelling and drug release than chemical redox initiated polymerization.

• 公益社団法人日本薬学会の論文
• 1999-04-15

著者

• Luo Yi

  Division Of Drugs National Institute Of Health Sciences:(present Address)department Of Medicinal Che

• Yoshioka Sumie

  Division Of Drugs National Institute Of Health Sciences

• ASO Yukio

  Division of Drugs, National Institute of Health Sciences

• Aso Yukio

  Division Of Drugs National Institute Of Health Sciences

関連論文

• Physical Stability of Amorphous Acetanilide Derivatives Improved by Polymer Excipients
• Swelling Behavior and Drug Release of Amphiphilic N-Isopropylacrylamide Terpolymer Xerogels Depending on Polymerization Methods : γ-Irradiation Polymerization and Redox Initiated Polymerization

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