USE OF PKM-MULTI PROGRAM FOR FITTING DISCONTINUOUS ABSORPTION PROFILES USING A MICROCOMPUTER

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概要

• 論文の詳細を見る

• The programs for the pharmacokinetic models with discontinuous absorption, written in BASIC, were connected to MULTI, which had been proposed for nonlinear least squares for a microcomputer by Yamaoka et al. Using this program (designated as PKMMULTI), the same data sets previously calculated by HFCM, FITISI2and NONLIN were fitted and the finally obtained estimates were in close agreement with those obtained previously. The plasma data of nalidixic acid were also fitted to the pharmacokinetic model with discontinuous absouption, which were suggested to be more valid compared with one compartment model with continuous absorption.

• 公益社団法人日本薬学会の論文

著者

• Kaniwa Nahoko

  Division Of Drugs National Institute Of Hygienic Sciences

• AOYAGI NOBUO

  Division of Drugs, National Institute of Hygienic Sciences

• Aoyagi Nobuo

  Division Of Drugs National Institute Of Hygienic Sciences

• OGATA KIROYASU

  Division of Drugs, National Institute of Hygienic Sciences

• Ogata Kiroyasu

  Division Of Drugs National Institute Of Hygienic Sciences

関連論文

• EFFECT OF FOOD ON BIOAVAILABILITY OF NALIDIXIC ACID FROM UNCOATED TABLETS HAVING DIFFERENT DISSOLUTION RATES
• DEVELOPMENT AND EVALUATION OF A NEW PERORAL TEST AGENT GA-TEST FOR ASSESSMENT OF GASTRIC ACIDITY
• BIOAVAILABILITY OF METRONIDAZOLE FROM SUGAR COATED TABLETS IN HUMANS AND ITS CORRELATION WITH BIOAVAILABILITY IN BEAGLE DOGS AND WITH IN VITRO DISSOLUTION RATE
• THE BIOAVAILABILITY OF FLUFENAMIC ACID FROM ALUMINUM FLUFENAMATE TABLET AND FLUFENAMIC ACID CAPSULE, AND THE INFLUENCE OF FOOD AND ALUMINUM HYDROXIDE GEL
• THE BIOAVAILABILITIES OF ASPIRIN FROM AN ASPIRIN ALUMINUM AND AN ASPIRIN TABLETS AND THE EFFECTS OF FOOD AND ALUMINUM HYDROXIDE GEL
• GASTRIC ACIDITY DEPENDENT BIOAVAILABILITY OF CINNARIZINE FROM COMMERCIALLY AVAILABLE CAPSULES IN HUMANS AND ITS CORRELATIONS WITH BIOAVAILABILITY IN BEAGLE DOGS AND WITH DISSOLUTION RATE
• Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers
• USE OF PKM-MULTI PROGRAM FOR FITTING DISCONTINUOUS ABSORPTION PROFILES USING A MICROCOMPUTER
• Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data(BIOINFORMATICS)

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