A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells(Biochemistry)
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概要
- 論文の詳細を見る
A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The synthetic quinone showed potent growth-inhibitory effects on rat hepatoma cells (IC_<50> value=1.9 μM). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 μM.
- 2008-04-01
著者
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Suzuki Koichi
Faculty of Agriculture, Iwate University
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YANG Ping
Faculty of Agriculture, Iwate University
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Yang Ping
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Fujiwara Yumiko
Graduate School Of Agriculture Iwate University
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Ohfune Yasufumi
Graduate School Of Science Osaka City University
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Shinada Tetsuro
Graduate School Of Science Osaka City University
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Kofujita Hisayoshi
Graduate School Of Agriculture Iwate University
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MANGETSU Makoto
Graduate School of Agriculture, Iwate University
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YANG Ping
Graduate School of Agriculture, Iwate University
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SUZUKI Koichi
Graduate School of Agriculture, Iwate University
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Mangetsu Makoto
Graduate School Of Agriculture Iwate University
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Yang Ping
Faculty Of Agriculture Iwate University
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Suzuki Koichi
Faculty Of Agriculture Iwate University
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