Novel Biologically Active Peptides from the Venom of Polistes rothneyi iwatai(Biochemistry)
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概要
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Four novel peptides, polistes-mastoparan-R1, 2, 3, and polistes-protonectin, were isolated from the venom of a paper wasp, Polistes rothneyi iwatai. MALDI-TOF MS analysis of a small amount of the crude venom gave six molecular-related ion peaks. Among them, m/z 1565 was expected to be a novel peptide. Purification of the crude venom by HPLC gave two known kinins, Thr^6-bradykinin and Ala-Arg-Thr^6-bradykinin, and four novel peptides named polistes-mastoparan-R1, 2, and 3, and polistes-protonectin. Polistes-mastoparan-R1, 2, and 3 (Pm-R) were tetradecapeptides that possess high sequence homology with that of mastoparan. The sequence of polistesprotonectin was similar to that of protonectin isolated from a Brazilian paper wasp. Histamine-releasing activities of Pm-R1, 2, and 3 were more potent than that of mastoparan. Polistes-protonectin exhibited the most potent hemolytic activity in comparison with the four novel peptides and mastoparan.
- 2006-12-01
著者
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NAKAJIMA Terumi
Suntory Institute for Bioorganic Research
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Murata Kazuya
Graduate School Of Science Osaka City University
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NAKAJIMA Terumi
Hoshi University
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NAOKI Hideo
Suntory Institute for Bioorganic Research
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Ohfune Yasufumi
Graduate School of Science, Osaka City University
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YASUDA Akikazu
Suntory Institute of Bioorganic Research
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Shinada Tetsuro
Graduate School of Science, Osaka City University
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Yasuda Akikazu
Suntory Institute For Bioorganic Research
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HISADA Miki
Suntory Institute for Bioorganic Research
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Ohfune Yasufumi
Graduate School Of Science Osaka City University
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Shinada Tetsuro
Graduate School Of Science Osaka City University
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Murata Kazuya
Graduate School Of Engineering Nagoya University
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