A New Polypeptide Toxin from the Nematocyst Venom of an Okinawan Sea Anemone Phyllodiscus semoni (Japanese name "unbachi-isoginchaku")(Biochemistry & Molecular Biology)
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概要
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The venomous sea anemone Phyllodiscus semoni causes cases of severe stinging. We isolated Phyllodiscus semoni toxin 20A (PsTX-20A), a hemolytic and lethal polypeptide (20kDa), from the nematocyst venom of this species for the first time. Furthermore, we sequenced the cDNA encoding PsTX-20A. The deduced amino acid sequence of PsTX-20A showed that this toxin was a new member of the actinoporin family, which consists of several cytolytic polypeptides originating from sea anemones. PsTX-20A showed lethal toxicity to the shrimp Palaemon paucidens when administered via intraperitoneal injection (LD_<50>, 50 μg/kg) and hemolytic activity toward 0.8% sheep red blood cells (ED_<50>, 80 ng/ml).
- 社団法人日本農芸化学会の論文
- 2002-12-23
著者
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Takuwa-Kuroda Kyoko
SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH
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Oshiro N
Okinawa Prefectural Inst. Health And Environment Okinawa Jpn
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NAKAJIMA Terumi
Suntory Institute for Bioorganic Research
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Iwanaga Setsuko
Okinawa Prefectural Institute Of Health And Environment
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Iwanaga Setsuko
Okinawa Prefectural Agricultural Experiment Station
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Oshiro Naomasa
Okinawa Prefecture Istitute Of Health And Environment
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NAGAI Hiroshi
Suntory Institute for Bioorganic Research
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NOZAKI Masatoshi
Okinawa Prefectural Institute of Health and Environment
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NAKAO Masahiro
Institute for Biomedical Research, Suntory Ltd.
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Oshiro N
Laboratories Of Applied Biochemistry University Of The Ryukyus
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Nakajima T
Suntory Institute For Bioorganic Research
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Nagai Hiroshi
Department Of Ocean Sciences Tokyo University Of Marine Science And Technology
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Nagai H
Suntory Institute For Bioorganic Research:(present Address)tokyo University Of Fisheries
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Nakao M
Institute For Biomedical Research Suntory Ltd.
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Iwanaga Shiroh
Laboratory Of Biochemistry Faculty Of Agriculture Graduate School Kyushu University
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Nagai H
Department Of Ocean Sciences Tokyo University Of Marine Science And Technology
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