Effects of 2-Nicotinamidoethyl Nitrate on the Cardiovascular System
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概要
- 論文の詳細を見る
Using the dog as experimental animal, effects on the cardiovascular system of a new vasodilator, 2-nicotinamidoethyl nitrate (SG-75), were studied.In the heart-lung preparation, the compound produced a dosedependent increase in the coronary blood flow, which was associated with only a minimal increase in the myocardial oxygen consumption. There was essentially no change in the myocardial function. The myocardial redox potential was shifted to more positive values. In the isolated perfused heart preparation (Langendorffs preparation), SG-75 produced a dilatation of only the small resistive arterioles. However, it produced a dilatation of the large conductive artery in underperfused myocardium.SG-75 produced a significant increase in the cerebral venous outflow, associated with an increase in the cerebro-spinal fluid pressure. It produced a reduction of the venous return, which was especially prominent in the lower half of the body.In the isolated smooth muscle preparation of the coronary artery, high-doses of SG-75 induced calcium antagonistic effects and produced a relaxation of the lanthanum contracture.
- International Heart Journal刊行会の論文
著者
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Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Tsukada Tokumasa
Department Of Pharmacology Niigata University School Of Medicine
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Nakagawa Yoshito
Department Of Pharmacology Niigata University School Of Medicine
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Takeda Keisuke
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Kitagawa Toshikazu
Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University
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OTORU Takeshi
Department of Pharmacology, Yamagata University School of Medicine
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IMAT Shoichi
Department of Pharmacology, Niigata University School of Medicine
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KATANO Yumi
Department of Pharmacology, Yamagata University School of Medicine
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NAKAGAWA Yoshito
Department of Pharmacology, Niigata University School of Medicine
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Kitagawa Toshikazu
Department of Chemistry for Materials, Graduate School of Engineering, Mie University, Tsu 514-8507, Japan
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