A COMPARISON OF THE DIFFERENTIAL EFFECTS OF NITROGLYCERIN, NIFEDIPINE AND PAPAVERINE ON CONTRACTURES INDUCED IN VASCULAR AND INTESTINAL SMOOTH MUSCLE BY POTASSIUM AND LANTHANUM
スポンサーリンク
概要
- 論文の詳細を見る
To elucidate the mechanisms of smooth muscle relaxant effects of nitroglycerin, the effects of this substance on the potassium contracture (K<SUP>+</SUP>-contracture) and the lanthanum-induced contracture (La<SUP>3+</SUP>-contracture) were studied using smooth muscle preparations of the canine coronary artery and colon and the findings compared with the effects of nifedipine, a representative calcium antagonistic vasodilator. The effects of papaverine, a prototype smooth muscle relaxant, were also studied. La<SUP>3+</SUP>-contracture was induced in a calcium-free environment with the addition of lanthanum, an effective blocker of calcium influx. In the coronary artery, nitroglycerin produced a relaxation both of the La<SUP>3+</SUP>-contracture and the K<SUP>+</SUP>-contracture. However, neither La<SUP>3+</SUP>-contracture nor K-contracture in the colon was affected. Nifedipine did not relax the La<SUP>3+</SUP>-contracture in a range of doses at which K<SUP>+</SUP>-contracture of both types of smooth muscles was relaxed. Papaverine produced a relaxation of La<SUP>3+</SUP>-contracture as well as K<SUP>+</SUP>-contracture, in both types of smooth muscles. Unlike the mechanism related to the relaxant effects of nifedipine, which is generally admitted to be an inhibition of calcium influx, the relaxant effect of nitroglycerin was attributed to the suppression of calcium release from the intracellular store sites and/or stimulation of calcium uptake into the intracellular store-sites. Papaverine was assumed to produce a relaxation through augmentation of the calcium binding to the intracellular store sites for calcium as well as through inhibition of the calcium influx.
- 社団法人 日本薬理学会の論文
著者
-
Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
-
Kitagawa Toshikazu
Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University
関連論文
- HYPOTENSIVE MECHANISMS OF CARVEDILOL
- Solvent Effects and Steric Course in the Solvolysis of 1,3,3-Trimethy1-2-oxocyclopentyl Mesylate in Comparison with 1,1,3,3-Tetramethy1-2-oxobutyl System
- Generation and Reactivity of 2-Substituted Adamantenes
- Generation and Reactions of 2-(1-Adamantyl)adamantene. Rearrangement to 3-(1-Adamantyl)-4-protoadamantylidene
- Three Binding Sites of ^I-Iodocyanopindolol, i.e. β_1,β_2-Adrenergic and 5HT_-Serotonergic Receptors in Rat Brain Determined by the Displacement and Scatchard Analysis
- Quantitative Analysis of the Antiarrhythmic Effect of Drugs on Canine Ventricular Arrhythmias by the Determination of Minimum Effective Plasma Concentrations : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
- PERIPHERAL EFFECTS OF GUANFACINE COMPARED TO THOSE OF CLONIDINE THE DOG
- CANINE EFFECTIVE PLASMA DISOPYRAMIDE CONCENTRATION IN TWO-STAGE CORONARY LIGATION VENTRICULAR ARRHYTHMIA : Antiarrhythmic Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ON THE EXISTENCE OF METABOLIC α-ADRENERGIC RECEPTOR IN THE MYOCARDIUM
- CORONARY VASODILATATION AND ADRENERGIC RECEPTORS IN THE DOG HEART AND CORONARY
- BINDING CHARACTERISTICS OF 3H-DIHYDROALPRENOLOL TO β-ADRENOCEPTORS OF RAT HEART TREATED WITH NEURAMINIDASE
- EFFECT OF NITROGLYCERIN ON Ca EFFLUX IN THE CORONARY ARTERY
- ANTIHYPERTENSIVE EFFECTS OF β-BLOCKERS IN HYPERTENSIVE RATS
- POSITIVE INOTROPIC AND CHRONOTROPIC EFFECTS OF 8-SUBSTITUTED DERIVATIVES OF 3, 5-CYCLIC AMP
- EFFECTS OF CYCLIC AMP AND DIBUTYRYL CYCLIC AMP ON THE HEART AND CORONARY CIRCULATION
- EFFECTS OF PROSTAGLANDINS ON LATE CORONARY LIGATION ARRHYTHMIAS IN THE DOG
- Self-Assembly and Scanning Tunneling Microscopy Tip-Induced Motion of Ferrocene Adamantane Trithiolate Adsorbed on Au(111)
- A COMPARISON OF ANTIHYPERTENSIVE EFFECTS OF ATENOLOL AND PROPRANOLOL IN THE SPONTANEOUSLY HYPERTENSIVE, DOCA/SALINE HYPERTENISVE AND RENAL HYPERTENSIVE RATS
- EFFECTS OF SEVERAL BETA-BLOCKING AGENTS ON THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
- ON THE HISTAMINE RECEPTOR OF THE CANINE MYOCARDIUM AND CORONARY VASCULATURE
- EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION
- Effects of Coronary Vasodilators on Large and Small Coronary Arteries of Dogs
- Diverse Relaxation Responses of Canine Large and Small Conductive Coronary Arteries to Glyceryl Trinitrate and Nitric Oxide on the One Hand and to 8-Bromoguanosine 3':5' Cyclic Monophosphate on the Other
- A COMPARISON OF THE DIFFERENTIAL EFFECTS OF NITROGLYCERIN, NIFEDIPINE AND PAPAVERINE ON CONTRACTURES INDUCED IN VASCULAR AND INTESTINAL SMOOTH MUSCLE BY POTASSIUM AND LANTHANUM
- Effects of Ethyl Adenosine-5-Carboxylate on the Heart and Coronary Circulation
- CARDIOTOXIC EFFECTS OF 5-FLUOROURACIL IN THE GUINEA PIG
- Effects of Piridoxilate, a Glyoxylic Acid Derivative, on the Energy Metabolism of the Heart
- Effects of Lidocaine and Procaine on the Action Potential of Canine Sinus Nodal Cells
- Structure and Function of Inositol 1 ,4,5 : Trisphosphate Receptor
- ANTIARRHYTHMIC EFFECT OF OXPRENOLOL ON HALOTHANE-EPINEPHRINE AND CORONARY LIGATION INDUCED VENTRICULAR ARRHYTHMIAS IN BEAGLE DOGS
- Hypotensive and Vascular Effects of Labetalol in the Normotensive Rat and Dog
- ANTAGONISTIC EFFECTS OF TRIMETAZIDINE TO ADRENALINE
- Small Difference in Cation Stability in Controlling the Formation of Hydrocarbon Salt or Covalent Hydrocarbon
- Significance of Steric Effect in the Heterolysis of Carbon-Carbon σ Bond in Ionically Dissociative Hydrocarbons
- ALPHA- AND BETA-BLOCKING ACTIVITIES OF RACEMATES OF LABETALOL
- DEVELOPMENT OF CORONARY COLLATERAL CIRCULATION IN MINIATURE SWINE AND EFFECTS OF SEVERAL DRUGS
- Effects of 2-Nicotinamidoethyl Nitrate on the Cardiovascular System
- Monofunctionalized C_ Ions: Their Generation, Stability, and Reactions
- Effect of l-Carnitine Chloride and Its Acetyl Derivative on the Electrophysiological Derangement Induced by Palmityl-l-Carnitine in Isolated Canine Ventricular Muscle
- Beneficial effects of diltiazem on the ischemic derangements of the myocardial metabolism assessed by 31P-NMR in the isolated perfused rat heart.
- Selectivity of bunitrolol for .BETA.1- and .BETA.2-adrenergic receptors and 5HT1B-receptors: Assessment by biphasic scatchard plots and biphasic displacement curve analysis with 125I-iodocyanopindolol and 3H-CGP12177.
- Effects of bunitrolol on adrenergic and serotonergic receptors.
- Beta-receptor blocking potencies of the three newly synthesized .BETA.-adrenergic antagonists (S-596,K-351,N-696) as assessed with the radioligand binding assay method in rat cardiac muscle membrane treated with neuraminidase.
- Displacement by .ALPHA.-adrenergic agonists and antagonists of 3H-prazosin bound to the .ALPHA.-adrenoceptors of the dog aorta and the rat brain.
- In Vitro Effects of the New Calcium Antagonist Lacidipine.
- Myocardial Na+ during Ischemia and Accumulation of Ca2+ after Reperfusion: A Study with Monesin and Dichlorobenzamil.
- Effects of deoxyribonuclease I and neuraminidase treatments on the specific binding of 3H-prazosin and 3H-quinuclidinyl benzilate (3H-QNB) to .ALPHA.-adrenergic and muscarinic receptors in rat myocardial membranes.
- Effects of cardioplegia induced by a young's solution (YNG solution) on the blood-perfused canine papillary muscle preparation.
- Enhanced responsiveness of the coronary blood vessel of the dog heart-lung preparation to PGI2 after chronic chemical sympathectomy.
- CARDIAC ACTIVE STEROIDS AND THE SLOW MUSCLE FIBRE
- Cardiotonic and coronary vasodilatatory effects of amrinone in the canine heart-lung preparation with a support dog as compared with those of dobutamine.
- Effect of carvedilol on venous return: A mechanism of reduction in blood pressure.
- On the Mechanism of Hypotensive Actions of β-blockers
- Mechanisms of the Acute Hypotensive Effect of β-Adrenergic Blocking Drugs with α-Blocking Activity in Conscious SHR
- Role of the .ALPHA.-adrenergic blocking effect in the acute hypotensive effect of .BETA.-adrenergic blocking drugs with .ALPHA.-blocking activities in conscious SHR.
- Inhibition by thiamine tetrahydrofurfuryl disulfide (TTFD) of the arachidonic acid cascade-line activation as evidenced in the heart-lung preparation of the dog.
- Effects of Lidocaine on Ischemic Myocardial Metabolism Assessed by 31P-NMR in the Isolated Perfused Rat Heart.
- Ventricular pressure-heart rate product before induction of ischemia as a determinant of the reperfusion-induced accumulation of calcium within myocardium.
- Functional and metabolic effects of cardioplegia induced by a young's solution (YNG solution) as assessed in isolated atrial preparations and in isolated perfused heart preparations of the guinea pig.
- Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses.
- The sequence and correlation of the changes in several parameters of energy metabolism induced by ischemic insult in heart muscle.
- Hemodynamic Effects of Benazeprilat in the Anesthetized Dog with Acute Left Ventricular Failure.
- .ALPHA.-Blockade and vasodilatation induced by nipradilol, arotinolol and labetalol in pithed rats.
- Sarcolemmal (Ca2++Mg2+)-ATPase of vascular smooth muscle and the effects of protein kinases thereupon.