Enhanced responsiveness of the coronary blood vessel of the dog heart-lung preparation to PGI2 after chronic chemical sympathectomy.
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概要
- 論文の詳細を見る
Chronic chemical denervation of the sympathetic nervous system with 6-OH dopamine resulted in an augmentation of the coronary blood flow (CBF) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto PGF<SUB>1α</SUB> in the circulating blood. In denervated HLP, 6-keto PGF<SUB>1α</SUB> was lower and the vasodilator response to PGI<SUB>2</SUB> larger at the start of the experiments. It was concluded that exaggerated increase in CBF was due to a potentiation of the vasodilator response to PGI<SUB>2</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Sakai Ken
Department Of Applied Physics Tokai University
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SHIMAMOTO Norio
Department of Pharmacology, Niigata University School of Medicine
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SAKAI Ken
Department of Pharmacology, Niigata University School of Medicine
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MATSUI Kazuki
Department of Pharmacology, Niigata University School of Medicine
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