Myocardial Na+ during Ischemia and Accumulation of Ca2+ after Reperfusion: A Study with Monesin and Dichlorobenzamil.
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概要
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The intracellular cation contents were determined in isolated perfused rat heart using cobaltic EDTA as a marker of the extracellular space. In hearts in which Na<SUP>+</SUP> accumulation was induced with monensin, a Na<SUP>+</SUP> ionophore, during 20 min-ischemia which otherwise did not result in accumulation of Na<SUP>+</SUP>, the levels of Na<SUP>+</SUP> and Ca<SUP>2+</SUP> were significantly higher after reperfusion with a significant decrease in K<SUP>+</SUP>. While the recovery of the cardiac mechanical function (CMF) was complete after reperfusion in control hearts, the recovery was incomplete in monensin-hearts. Dichlorobenzamil (DCB), the most specific inhibitor of Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger, infused for 10 min before induction of ischemia in a dose of 10<SUP>-5</SUP> M, which produced a definite suppression of CMF (over 80%), inhibited the accumulation of Ca<SUP>2+</SUP> and Na<SUP>+</SUP> and the loss of K<SUP>+</SUP> and ATP after 40 min-ischemia and reperfusion. The same dose of DCB given for 3 min before induction of ischemia and after reperfusion, which produced a less than 20% inhibition of CMF, failed to prevent the Ca<SUP>2+</SUP> accumulation after 40 min-ischemia and reperfusion. These findings are at variance with the idea that the accumulation of Na<SUP>+</SUP> during ischemia and the consequent augmented operation of Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchange is responsible for accumulation of Ca<SUP>2+</SUP> after reperfusion.
- 公益社団法人 日本薬理学会の論文
著者
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Sakurai Hiroshi
Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Yoshida Yutaka
Deparlment Of Internal Medicine School Of Medicine Kobe University
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KAWADA Tomie
Department of Clinical Pharmacology, Faculty of Pharmacy, Musashino University
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KAWADA Tomie
Department of Pharmacology, Niigata University School of Medicine
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