Functional and metabolic effects of cardioplegia induced by a young's solution (YNG solution) as assessed in isolated atrial preparations and in isolated perfused heart preparations of the guinea pig.

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The protective effects of Young's solution (YNG solution), a cardioplegic solution, on the myocardial function and metabolism were assessed in isolated atrial preparations and isolated perfused heart preparations of the guinea pig. In atrial preparations, the time to arrest of the contraction became shorter as the concentrations of the K+, Mg++, and K+-Mg++ solutions increased, while the time to resumption of the contraction was lengthened. There was no difference in the time to arrest between K+ and K+-Mg++ solutions, but the time to resumption was reduced with K+-Mg++ solution to about half the value with K+ solution. YNG solution represented an optimum solution for obtaining a quick cardiac arrest and quick resumption of contraction. In the isolated perfused heart, the time to arrest was similar for all the cardioplegic solutions used and the heart stopped in diastole. However, the time to arrest was longer with cold Krebs-Henseleit's solution (cold cardioplegia). The time to resumption of the contraction was the shortest with YNG solution, which yielded the highest mitochondria) respiratory control ratio (RCR) and ADP/O ratio. There was a negative correlation between the time to resumption of contraction and mitochondrial RCR or ADP/O ratio (r=-0.50 and -0.58, respectively).
International Heart Journal刊行会の論文