Differential Inhibition by Oxygen Radicals of Vasoactive Amines-Induced Contractions in the Porcine Coronary Artery(Pharmacology)
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概要
- 論文の詳細を見る
Reactive oxygen species (ROS) play an important role in normal metabolic and signaling processes. Excess ROS, however, can cause severe cardiovascular damage. Thus, the present study was designed to examine effects of H_2O_2 and xanthine plus xanthin oxidase (X/XO) on the serotonin (5HT), histamine (His) and acetylcholine (ACh)-induced contractions of porcine coronary arteries. In addition, to explore the site of ROS formation and species of it, the inhibitory effects of edaravone and EDTA were also tested. 5HT- and His-induced contractions were suppressed by H_2O_2 and X/XO treatment. However, these suppressions of ACh-induced contraction by H_2O_2 treatment was relatively weak and X/XO treatment caused no suppression on ACh-induced contraction. In the presence of edaravone which is thought to be a scavenger for ・OH, significant decrease of inhibition of 5HT- and His-induced contractions was observed when coronary artery strips were treated with X/XO, but not H_2O_2. On the other hand, inhibitory effects by EDTA treatments were also observed in X/XO treatments. These results suggest that 1) ROSs produced by additions of H_2O_2 or X/XO are considered to be responsible for several physiological functions of coronary artery contractions, 2) the site of ROS produced by X/XO system, probably ・OH, was outside the cell, but the inhibitory action of H_2O_2, was inside the cell, and 3) a low susceptibility of AChinduced contraction to H_2O_2 and X/XO may indicates the signal transduction pathway(s) of ACh-induced contraction is different from those of 5HT and His.
- 公益社団法人日本薬学会の論文
- 2007-07-01
著者
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Nakazawa Mikio
Department of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University
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HOSSAIN Murad
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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NAGATOMO Takafumi
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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長友 孝文
新潟薬科大学薬学部薬理学教室
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Ahmed Maruf
Pharmacy Department University Of Rajshahi
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Ahmed Maruf
バングラデシュ
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Nakazawa M
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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MUNTASIR Habib
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and A
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Nagatomo T
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Niigata Univ. Of Pharmacy And Applied Life Scie
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MIYAJIMA Kaori
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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AHMED Maruf
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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Muntasir Habib
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Miyajima Kaori
Department Of Pharmacology Niigata University Of Pharmacy And Applied Life Sciences
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Nakazawa Mikio
Departement Of Medical Technology School Of Health Sciences Faculty Of Medicine Niigata University
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Nagatomo Takafumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Hossain Murad
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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