EFFECTS OF PROSTAGLANDIN E<SUB>2</SUB>, I<SUB>2</SUB> AND F<SUB>2α</SUB> ON SYSTEMIC AND RENAL HEMODYNAMICS, RENAL FUNCTION AND RENIN SECRETION IN ANESTHETIZED DOGS
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Effects of intrarenal-arterial (i.r.a.) and intravenous (i.v.) infusions of PGE<SUB>2</SUB>, I<SUB>2</SUB> and F<SUB>2α</SUB> on systemic blood pressure (BP), heart rate (HR), renal blood flow (RBF), urine volume (UV), renal function and plasma renin activity (PRA) of the renal venous blood (RVPRA) were investigated. A dose-dependent fall in BP was observed with PGE<SUB>2</SUB> and I<SUB>2</SUB> and was accompanied by a tachycardia (PGE<SUB>2</SUB><I<SUB>2</SUB>, i.r.a.<i.v.). PGE<SUB>2</SUB> and I<SUB>2</SUB> induced increases in RBF and UV in a roughly dose-dependent manner (PGE<SUB>2</SUB>>I<SUB>2</SUB>, i.r.a.>i.v.), however, antidiuresis was observed with the highest intravenously given dose of PGI<SUB>2</SUB> (300 ng/kg/min) such being ascribed to a pronounced hypotension. Changes in electrolyte excretion induced by PGE<SUB>2</SUB> and I<SUB>2</SUB> were similar to the pattern of those in RBF or UV. Neither PGE<SUB>2</SUB> or I<SUB>2</SUB> produced any significant changes in the glomerular filtration rate (GFR). The diuretic effect of PGE<SUB>2</SUB> and F<SUB>2α</SUB> correlated with osmolar clearance (C<SUB>osm</SUB>) (r=0.89, p<0.01 ; r=0.55, p<0.01) and free water clearance (C<SUB>H<SUB>2</SUB>O</SUB>) (r=0.52, p<0.01 ; r=0.83, p<0.01), whereas that of PGI<SUB>2</SUB>, only with C<SUB>osm</SUB> (r=0.74, p<0.01). PGF<SUB>2α</SUB> produced the weakest changes in the parameters described above. PGE<SUB>2</SUB> and I<SUB>2</SUB> (30 ng/kg/min, i.r.a.), but not PGF<SUB>2α</SUB>, produced a significant elevation of RVPRA without any significant change in BP. These findings suggest that PGE<SUB>2</SUB> plays a primary role in the kidney, whereas PGI<SUB>2</SUB> is important in the regulation of the systemic circulation, and that PGE<SUB>2</SUB>, I<SUB>2</SUB> and F<SUB>2α</SUB> all have different modes of action in producing diuresis. Both PGE<SUB>2</SUB> and I<SUB>2</SUB> may participate in the control of renin secretion.
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