THE SUPPRESSIVE ACTIVITIES OF ALPRENOLOL AGAINST DESLANOSIDE-INDUCED CARDIOTOXICITIES IN GUINEA PIGS
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概要
- 論文の詳細を見る
The cardiotoxicities produced by a continuous infusion of desacetyl-lanato-side C (deslanoside) alone in guinea pigs were definitely suppressed by concomitant infusion of a beta-adrenoceptor blocking agent, alprenolol (aptin, H56/28). However, the antagonistic potency of alprenolol was smaller than that of propranolol, although according to the literatures the potency of beta-adrenoceptor blocking activity of the former was said to be no less than that of the latter. That is, the correlation between the antagonistic potency against deslanoside-induced cardiotoxicities and the potency of beta-adrenoceptor blocking activity of alprenolol did not run parallel in contrary to that of propranolol. It seems probable that the suppressive activity of alprenolol against deslanoside-induced cardiotoxicities is not based on the specific action on the beta-adrenoceptor.
- 社団法人日本循環器学会の論文
- 1973-06-20
著者
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OTORII Takeshi
Department of Pharmacology, Niigata University School of Medicine
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Kojima Tetsuo
Department Of Pharmacology Niigata University School Of Medicine
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Otorii Takeshi
Department Of Pharmacology Niigata University School Of Medicine
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Otorii Takeshi
Department Of Pharmacology Niigata University Schcol Of Medicine
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NITO MASAAKI
Department of Pharmacology, Niigata University School of Medicine
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Nito Masaaki
Department Of Pharmacology Niigata University School Of Medicine
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OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
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