Antagonism of hypotensive and bradycardic effects of centrally administered guanfacine by metiamide in anesthetized rabbits.
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概要
- 論文の詳細を見る
In anesthetized rabbits, intracerebroventricular (ICV) administration of the α-adrenoceptor agonist, guanfacine, like clonidine, elicited dose-related falls in arterial blood pressure and heart rate. ICV pretreatment with the histamine H2-receptor antagonist, metiamide, significantly reduced the hypotensive and bradycardic responses caused by ICV injection of either guanfacine or clonidine. The present results seem to indicate that the antagonistic effect of metiamide against either guanfacine or clonidine is probably due to its α-adrenoceptor blocking action rather than its histamine H2-receptor blocking action, suggesting that these interactions might be of central origin.
- International Heart Journal刊行会の論文
著者
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Suzuki Kenichi
Department Of Biochemistry Meiji College Of Pharmacy:central Research Institute Yamanouchi Parmaceut
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OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
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OHKUBO Kazuhiro
Department of Pharmacology, Yamagata University School of Medicine
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- Antagonism of hypotensive and bradycardic effects of centrally administered guanfacine by metiamide in anesthetized rabbits.