EFFECTS OF BETA-ADRENORECEPTOR BLOCKING AGENTS ON THE DESLANOSIDE-INDUCED ARRHYTHMIA AND CARDIAC ARREST IN GUINEA PIGS

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It seems very probable that of beta-adrenergic receptor blocking agents currently used, 4-(2-hydroxy-isopropylamino-propoxy)-indole (LB-46) has the most potent beta-adrenergic blocking activity. The present investigation aimed at illuminating the protective effect of LB-46 on desacetyl-lanatoside C (deslanoside)-induced toxicity to the heart of guinea pigs by means of the analysis of dose-response curves in comparison with propranolol. As the result both beta-adrenergic receptor antagonists showed a considerable suppressive activity against deslanoside-induced cardiotoxicity at the serial infusion rate of deslanoside. Thus there was no apparent difference between the potency of the antagonistic activity of both drugs against cardiotoxicity and that of their beta-adrenergic activity. Consequently it was impossible to con-firm the possibility of correlation between an antagonistic potency against cardiotoxicity and a beta-adrenergic receptor blocking potency of both drugs. These results may suggest that the mechanism of the suppressive activity of LB-46 against deslanoside-induced cardiotoxicity is unrelated to the adrenergic influence.
社団法人日本循環器学会の論文