Endocardial Arrhythmogenic Mechanisms of Torsades de Pointes in Patients with the Congenital Long QT Syndrome
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概要
- 論文の詳細を見る
We injected acetylcholine (Ach) into the coronary artery to ascertain whether coronary vasospasm contributed to the syncopal events or chest oppression suffered by 3 patients with long QT syndrome (LQTS). During the test, a quadripolar electrode catheter was placed in the right ventricle and the activation-recovery interval was reanalyzed from the stored data. Intracoronary Ach transiently prolonged the QT intervals in all 3 patients without inducing coronary vasospasm. The Ach-induced QT prolongation was associated with enhanced spatial and temporal dispersion of intra-ventricular repolarization. The electrophysiological abnormalities were consistent with the putative arrhythmogenic mechanisms identified in experimental studies of LQTS.
著者
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Chinushi Masaomi
School Of Health Science Niigata University School Of Medicine
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Hosaka Yukio
The First Department of Internal Medicine, Niigata University School of Medicine
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Komura Satoru
The First Department of Internal Medicine, Niigata University School of Medicine
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Furushima Hiroshi
The First Department Of Internal Medicine Niigata University School Of Medicine
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Sato Akinori
The First Department Of Internal Medicine Niigata University School Of Medicine
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Aizawa Yoshifusa
The First Department Of Internal Madicine Niigata University School Of Medicine
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Chinushi Masaomi
School of Health Science, Niigata University, Japan
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Komura Satoru
The First Department of Internal Medicine, Niigata University, Japan
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Iijima Kenichi
The First Department of Internal Medicine, Niigata University of Medicine
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Iijima Kenichi
The First Department of Internal Medicine, Niigata University, Japan
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