Magnesium Treatment for Drug-Induced QT Prolongation
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概要
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Effects of magnesium administration (0.2 ml/kg, iv) on the QT interval and transmural ventricular repolarization were compared among the 4 models of QT interval prolongation: (20 experiments) bepridil (BEP), amiodarone (AMD), E-4031 (E) or anthopleurin-A (AP-A). Using plunge needle electrodes, transmural electrograms were obtained from the left ventricle, and the activation-recovery interval (ARI) and transmural ARI-dispersion were analyzed. <B>Results:</B> (1) After administration of each drug, ARIs at all LV layers were prolonged, and transmural ARI-dispersions were enlarged in the AP-A and E models. BEP (4 mg/kg) homogeneously prolonged ARIs, and it produced a relatively small transmural ARI-dispersion (32±10 ms) similar to the AMD model (1.5 mg/kg/hr) (32±7 ms). (2) Magnesium injection (0.2 mEq/kg, iv) shortened ARIs and suppressed Torsades de Pointes in the AP-A model. (3) Magnesium did not shorten nor homogenize ARI distribution in the other 3 models. Magnesium slightly prolonged the ARIs in the E model. <B>Conclusions:</B> Magnesium did not reduce the transmural dispersion of repolarization except in AP-A model. Inhibition of the triggered premature beats seems to be another therapeutic effect of magnesium treatment for QT interval prolongation.
著者
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Furushima Hiroshi
First Department Of Internal Medicine Niigata University School Of Medicine
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Chinushi Masaomi
School Of Health Science Niigata University School Of Medicine
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Iijima Kenichi
First Department Of Internal Medicine Niigata University School Of Medicine
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Izumi Daisuke
First Department Of Internal Medicine Niigata University School Of Medicine
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Aizawa Yoshifusa
First Department Of Internal Medicine Niigata Universaity School Of Medicine
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Chinushi Masaomi
School of Health Science, Faculty of Medicine, Niigata University
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Hasegawa Kanae
First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Sato Akinori
First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Iijima Kenichi
First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences
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Izumi Daisuke
First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental Sciences
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AIZAWA Yoshifusa
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
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