Amiodarone Therapy in Patients Implanted With Cardioverter-Defibrillator for Life-Threatening Ventricular Arrhythmias
スポンサーリンク
概要
- 論文の詳細を見る
Background Whether amiodarone can improve the patient's clinical outcome by reducing implantable cardioverter-defibrillator (ICD) therapy deliveries for ventricular tachycardia or fibrillation (VT/VF) has not been clearly evaluated. Methods and Results A total of 507 patients with VT/VF due to organic heart disease who had ICDs implanted were enrolled in this study. The patients were divided into 3 groups: Amiodarone (n=247), Class I antiarrhythmic drug (n=103) and Control (n=157) groups, and the total cause mortality and arrhythmic event free survival rates were evaluated between the groups. The mean follow-up period was 38±27 months. The left ventricular ejection fraction was significantly decreased in the Amiodarone group (Amiodarone: 37±15%; Class I: 39±16%; Control: 44±17%). The mortality and arrhythmic events were significantly higher in the Class I group than the Amiodarone group (p<0.05), but there was no significant difference between the Amiodarone and Control groups (arrhythmic event free rate at 5 years: Amiodarone: 53%; Class I: 35%; Control: 48%; 5 year survival: 86%, 74% and 77%, respectively). Side effects from amiodarone were found in 12% of the patients, but no fatal events were observed. Conclusions The present study could not demonstrate the benefit of amiodarone in ICD patients, probably due to a significant clinical bias exerted in selecting this drug.
- 社団法人日本循環器学会の論文
- 2006-07-20
著者
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Satomi Kazuhiro
Division of Cardiology, National Cardiovascular Center
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Kurita Takashi
Division of Cardiology, National Cardiovascular Center
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NITTA TAKASHI
Department of Surgery, Cardiovascular Surgery, Nippon Medical School
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Takatsuki Seiji
Cardiovascular Division Department Of Internal Medicine Keio University School Of Medicine
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Kamakura Shiro
Department Of Cardiovascular Surgery National Cardiovascular Center
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Satomi Kazuhiro
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Kamakura Shiro
国立循環器病センター
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Chinushi Masaomi
School of Health Science, Niigata University School of Medicine
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Kurita Takashi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Kobayashi Takashi
Icd Committee Of The Japanese Heart Rhythm Society
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Kubo Takashi
Project Team For Pharmacogenetics National Institute Of Health Sciences
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MITAMURA Hideo
Saiseikai Central Hospital
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Mitamura Hideo
Department of Cardiology, Saiseikai Central Hospital
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Tsuboi Naoya
Department of Cardiology, Social Insurance Chukyo Hospital
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Tsuboi Naoya
Department Of Cardiology Social Insurance Chukyo Hospital
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Tsuboi Naoya
Department Of Cardiology Nagoya Daini Red Cross Hospital
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Chinushi Masaomi
Niigata School Of Health Science
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Chinushi Masaomi
First Department Of Internal Medicine Niigata University School Of Medicine
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Chinushi Masaomi
School Of Health Science Niigata University School Of Medicine
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Mitamura H
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Mitamura Hideo
Department Of Cardiology Saiseikai Central Hospital
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Nitta takashi
ICD committee of the Japanese Heart Rhythm Society
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Shoda Morio
Department of Cardiology, Tokyo Women's Medical University
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Yokoyama Yasuhiro
Cardiovascular Center, Yokosuka Kyosai General Hospital
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Satomi Kazuhiro
The NATIVE
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Kurita Takashi
The NATIVE
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Matsubara Hiromi
Departments of Cardiovascular Medicine
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Yokoyama Yasuhiro
Cardiac Center Yokosuka Kyosai General Hospital
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Shoda Morio
Department Of Cardiology The Cardiovascular Center Of Sendai
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Mori Hidezo
The Native
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Mitamura Hideo
Division Of Cardiology Tokyo Saiseikai Central Hospital
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Takanaka Kotoe
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Takatsuki Seiji
Cardiology Division Department Of Medicine Keio University School Of Medicine
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Kurita Takashi
From The Icd Committee Of The Japanese Heart Rhythm Society
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NITTA Takashi
From the ICD committee of the Japanese Heart Rhythm Society
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Nitta Takashi
Department Of Biological Regulation And Regenerative Surgery Nippon Medical School Graduate School O
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Hiraoka Masayasu
Tokyo Medical And Dental University Medical Research Institute
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Shimomura Katusro
National Cardiovascular Center Division Of Cardiology
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Mitamura Hideo
Cardiopulmonary Division Department Of Internal Medicine Keio University School Of Medicine
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Chinushi Masaomi
Department Of Clinical Pharmacology Niigata College Of Pharmacology
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Shoda Morio
Department Of Cardiology Tokyo Women's Medical University Graduate School Of Medicine
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SATOMI Kazuhiro
Division of Arrhythmias and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Satomi Kazuhiro
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Kurita Takashi
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan
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