Electrocardiographic and Electrophysiologic Studies in Patients with Torsades de Pointe : Role of Monophasic Action Potentials : 53th Annual Scientific Session of the Japanese Circulation Society

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概要

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• The study group consisted of 26 patients with a history of documented Torsade de Pointes (TdP) who were divides into 3 groups according to the causes of TdP. Group I consisted of 5 patients with congenital long QT syndrome. Group II consisted of 15 patients with TdP caused by antiarrhythmic drugs. Group III consisted of 6 patients with TdP caused by bradycardia resulting from third degree atrioventricular block. The QT interval was determined from a 12-lead electrocardiogram. Monophasic Action Potential (MAP) was recorded by a 6 F USCI electrode catheter. Isoproterenol infusion resulted in TU abnormality in all patients in Group I and induced a hump at phase 3 slope of MAP in all 3 patients tested. The QT interval change before and after IA administration was significantly larger in Group II patients compared to those without TdP (0.132±0.062 vs 0.029±0.31 sec, <0.005). Injection of 100 mg. of disopyramide in 2 patients in Group II resulted a hump at phase 3 slope of the MAP in both of them. The QT prolongation associated with decreasing the pacing rate from 70 to 50/min was significantly larger in patients with Group III compared to patients with bradycardia but without TdP (0.02±0.04 vs 0.07±0.05 sec, <0.005). The results suggests: l) different approaches are necessary for evaluation of TU abnormalities in patients with TdP according to the causes of TdP. 2) MAP might be a useful method for evaluating TU abnormality in patients with TdP.

• 社団法人日本循環器学会の論文
• 1990-10-20

著者

• Kurita Takashi

  Division of Cardiology, National Cardiovascular Center

• Aihara Naohiko

  Division of Cardiology, National Cardiovascular Center

• Kamakura Shiro

  Division of Cardiology, National Cardiovascular Center

• Aihara Naohiko

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Kurita Takashi

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Ohe Tohru

  Cardiovascular Medicine, Okayama University

• Ohara Takahiro

  国立循環器病センター 心臓血管内科

• Ohe Tohru

  Japanese Lqts Multicenter Registry By The Minister Of Health Lobour And Welfare National Cardiovascu

• Ohe Tohru

  Executive Committee for JALT-2 Study Group

• Shimomura Katsuro

  Division of Cardiology, national Cardiovascular Center

• OHE THORU

  Division of Cardiology, National Cardiovascular Center

• MATSUHISA MOKUO

  Division of Cardiology, National Cardiovascular Center

• MATSUHISA Mokuo

  National Cardiovascular Center

• Matsuhisa Mokuo

  Division Of Cardiology National Cardiovascular Center

• Shimomura Katsuro

  Division Of Cardiology Department Of Medicine National Cardiovascular Center

• Ohe Toru

  The Sakakibara Heart institute of Okayama

• Matsuhisa Mokuo

  National Cardiovascular Center Division Of Cardiology

• Ohe Tohru

  Department Of Cardiovascular Surgery And Cardiology

• Matsuhisa Mokuo

  National Cardiovascular Center Osaka

• Kamakura Shiro

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Ohe Tohru

  Department Of Cardiovascular Surgery National Cardiovascular Center

• Ohe Toru

  Cardiac Division Department Of Medicine National Cardiovascular Center Hospital

• Shimomura Katusro

  National Cardiovascular Center Division Of Cardiology

• Kamakura Shiro

  Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral

• Aihara Naohiko

  Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Kurita Takashi

  Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan

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