Electrophysiologic Study-Guided Amiodarone for Sustained Ventricular Tachyarrhythmias Associated With Structural Heart Diseases
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概要
- 論文の詳細を見る
Background Although an electrophysiologic study (EPS) and Holter-monitoring are often helpful in evaluating the efficacy of antiarrhythmic drugs in patients with ventricular tachyarrhythmias (ventricular tachycardia/fibrillation (VT/VF)), the efficacy of EPS- or Holter-guided oral amiodarone therapy in Japanese patients is still unclear. Methods and Results EPS was performed 1 month after starting amiodarone, and Holter-monitoring was recorded before and 1 month after amiodarone in 188 patients with sustained VT/VF because of structural heart diseases. In spite of the judgment of EPS (n=89) or Holter (n=75), all patients continued amiodarone. Patients were followed up to 3 years and the primary endpoint was VT/VF recurrence and secondary endpoint was death by all cause. Kaplan-Meier estimated the risk of VT/VF recurrence was significantly smaller with EPS-guided amiodarone (p<0.01) but not with Holter-guided amiodarone. Multivariate Cox hazard analysis revealed that EPS-guided amiodarone was an independent factor suppressing the recurrence of VT/VF (p<0.05, 95% confidence interval=0.15 to 0.96). In the subgroup analysis, EPS-guided amiodarone was effective in patients with relatively well-preserved left ventricular ejection fraction (LVEF≥0.30) but not in patients with lower LVEF (LVEF<0.30). Conclusion EPS-guided amiodarone was useful for preventing recurrence of VT/VF in patients with a relatively well-preserved LVEF, but not always beneficial inpatients with a lower LVEF.
- 社団法人日本循環器学会の論文
- 2007-12-20
著者
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Okamura Hideo
Division of Cardiology, National Cardiovascular Center
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Noda Takashi
Division of Cardiology, National Cardiovascular Center
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Satomi Kazuhiro
Division of Cardiology, National Cardiovascular Center
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Shimizu Wataru
Division of Cardiology, National Cardiovascular Center
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Suyama Kazuhiro
Division of Cardiology, National Cardiovascular Center
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Kurita Takashi
Division of Cardiology, National Cardiovascular Center
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Aihara Naohiko
Division of Cardiology, National Cardiovascular Center
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Kamakura Shiro
Division of Cardiology, National Cardiovascular Center
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Aihara Naohiko
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Odakura Hironori
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Shirao K
Department Of Cardiovascular Surgery National Cardiovascular Center
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Satomi Kazuhiro
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Suyama Kazuhiro
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Aiba Takeshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Ashihara Takashi
Department Of Cardiovascular And Respiratory Medicine Heart Rhythm Center Shiga University Of Medica
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Ashihara Takashi
Department Of Cardiovascular Medicine Shiga University Of Medical Science
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Taguchi Atsushi
Division of Cardiology, Department of Medicine, National Cardiovascular Center
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Shirao Kuniaki
国立医薬品食品衛生研究所
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Kurita Takashi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Kobayashi Takashi
Icd Committee Of The Japanese Heart Rhythm Society
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Takahashi Nobuki
Department Of Clinical Studies And Genetics Radiation Effects Research Foundation
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Okamura Hideo
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Yamagata Kenichiro
Japanese Brugada Multicenter Registry By The Minister Of Health Labour And Welfare National Cardiova
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Arafune Tatsuhiko
National Inst. Of Advanced Industrial Sci. And Technol.
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Arafune T
Graduate School Of Frontier Sciences The University Of Tokyo
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Arafune Tatsuhiko
Inst. For Human Sci. & Biomed. Eng. National Inst. Of Advanced Industrial Science And Tech.
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Arafune Tatsuhiko
名古屋大学環境医学研究所
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Oya Hideo
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Aiba Takeshi
Division Of Cardiology Johns Hopkins University School Of Medicine
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Yamagata Kenichiro
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
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Tamura Koji
Department Of Cardiology Tokyo Women's Medical University Heart Institute Of Japan
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Ohya Hideo
Internal Medicine National Cardiovascular Center
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Taguchi Atsushi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Shimizu Wataru
Division Of Arrhythmia And Electrophysiology Department Of Cardiology National Cerebral And Cardiova
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Nagai Takayuki
Icd Committee Of The Japanese Heart Rhythm Society
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Yamagata Kenichiro
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral
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Aiba Takeshi
Division Of Arrhythmia And Electrophysiology Department Of Cardiology National Cerebral And Cardiova
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Kamakura Shiro
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Okamura Hideo
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral
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Kamakura Shiro
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral
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Shimizu Wataru
Division Of Cardiology Department Of Internal Medicine National Cerebral And Cardiovascular Center H
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Aiba Takeshi
Department Of Cardiovasculardynamics National Cardiovascular Center
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SATOMI Kazuhiro
Division of Arrhythmias and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Suyama Kazuhiro
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Aihara Naohiko
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Satomi Kazuhiro
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan
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Noda Takashi
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan
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Satomi Kazuhiro
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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Kurita Takashi
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan
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Noda Takashi
Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
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