The Effectiveness of Nifekalant Hydrocholoride for Treatment of Refractory Ventricular Arrhythmia
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概要
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<B>Methods:</B> A total of 24 consecutive patients suffered sustained ventricular tachycardia (VT) (group A: n=13), ventricular fibrillation (VF) (group B: n=7) or repeated non-sustained ventricular tachycardia (NSVT) (group C: n=4). ventricular arrhythmia (VA) was complicated with ischemic heart disease (IHD) in 11 patients (group I) and with other diseases in another 13 patients (group non-I). Nifekalant hyddrochloride (NIF) was administrated during cardiopulmonary resuscitation (CPR) in 13 patients. <B>Results:</B> NIF administration was effective in terminating VA in 19 of 24 patients (79.2%). NIF administration directly terminated VT in 6 patients, and VT was successfully cardioverted using additional direct-current (DC) shock after NIF administration in another 4 patients in group A with DC shock-resistant VT. Refractory VF was also successfully cardioverted by additional DC shock after NIF administration in 4 patients in group B. Repeated NSVT was not undertaken after NIF administration in all patients in group C. NIF was effective in terminating VA in all patients in group I as well as in 8 patients in group non-I. In 11 of 17 patients, continuous intravenous NIF infusion prevented the recurrence of VA. VA was successfully controlled by continuous intravenous infusion of NIF in 6 of 10 patients in group I. <B>Conclusion:</B> Nifekalant was effective in terminating refractory ventricular arrhythmia.
著者
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Chinushi Masaomi
School Of Health Science Niigata University School Of Medicine
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Ochiai Yukie
Departments Of Molecular Genetics Niigata University
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Aizawa Yoshifusa
First Department Of Internal Medicine Niigata Universaity School Of Medicine
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Nakamura Yuichi
Department Of Cardiology Shin-nittetsu Muroran General Hospital
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Tagawa Minoru
Department of Cardiology, Nagaoka Chuo General Hospital
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Ochiai Yukie
Department of Cardiology, Nagaoka Chuo General Hospital
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Aizawa Yoshifusa
First Department of Internal Medicine, Niigata University
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AIZAWA Yoshifusa
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
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