Ventricular Tachyarrhythmias in a Canine Model of LQT3 Arrhythmogenic Effects of Sympathetic Activity
スポンサーリンク
概要
- 論文の詳細を見る
The ventricular tachyarrhythmias associated with the LQT3 syndrome are typically bradycardia-dependent. However, some episodes can be associated with exercise or emotional stress, suggesting a different arrhythmogenic mechanism when sympathetic activity predominates. This study examined the potential arrhythmogenic mechanisms during periods of autonomically mediated transient heart rate acceleration in a canine anthopleurin-A model of LQT3 syndrome. Using plunge needle electrodes, transmural unipolar electrograms of the left ventricle were recorded from endocardial (Endo), mid-myocardial (Mid) and epicardial (Epi) sites. The activation-recovery interval (ART) was measured to estimate local refractoriness. The cardiac cycle length was gradually shortened by cessation of vagal stimulation (vagal stimulation protocol (VSP)), and intramural electrograms and onset mode of ventricular tachyarrhythmias were analyzed in 7 experiments. The VSP was performed 8 times before and 5 times after administration of mexiletine in each experiment. Before mexiletine, vagal stimulation slowed the heart rate and created large transmural ARI dispersion because of a greater ART prolongation at Mid rather than Epi/Endo sites. After cessation of vagal stimulation, unipolar electrograms started to show ARI alternans and ventricular premature beats developed sporadically. Sustained ventricular tachyarrhythmias were induced in 12 of the 56 trials of the VSP. Initiation of ventricular tachyarrhythmias was associated with delayed conduction at Mid/Endo sites. Mexiletine attenuated transmural ARI dispersion, and neither ARI alternans nor ventricular tachyarrhythmias was observed during all 35 trials of the VSP after mexiletine administration. Heart rate acceleration induced by an abrupt shift to a state of predominant sympathetic activity enhances arrhythmias in this LQT3 model. Mexiletine homogenizes ventricular repolarization, suppresses premature complexes and was antiarrhythmic during ventricular tachyarrhythmias induced by the VSP.
- 社団法人日本循環器学会の論文
- 2003-02-20
著者
-
Chinushi Masaomi
School of Health Science, Niigata University School of Medicine
-
Chinushi Masaomi
First Department Of Internal Medicine Niigata University School Of Medicine
-
Chinushi Masaomi
School Of Health Science Niigata University School Of Medicine
-
Komura Satoru
First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine
-
Washizuka Takashi
First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine
-
HOSAKA Yukio
First Department of Internal Medicine, Niigata University School of Medicine
-
Hosaka Yukio
First Department Of Internal Medicine Niigata University School Of Medicine
-
Washizuka Takashi
First Department Of Internal Medicine Niigata University School Of Medicine
-
Sugiura Hirotaka
The Division of Cardiology Niigata University Graduate School of Medical and Dental Sciences
-
Komura S
1st Department Of Internal Medicine Niigata University School Of Medicine
-
Sugiura Hirotaka
First Department of Internal Medicine Niigata University Hospital
-
Tagawa Minoru
Divisions Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences
-
Washizuka Takashi
Division Of Cardiology Niigata University Graduate School Of Medical And Dental Science
-
Tagawa Minoru
First Department of Internal Medicine, Niigata University School of Medicine
-
Aizawa Yoshifusa
School of Health Science, Niigata University School of Medicine
-
Kominami Satoshi
Department Of Respiratology Graduate School Of Medicine Chiba University
-
WASHIZUKA Takashi
First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.
関連論文
- PJ-004 Clinical and ECG Characteristics as a Predictor of Recurrence of Ventricular Tachyarrhythmia (VTA) in Patients with Hypertrophic Cardiomyopathy (HCM)(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annua
- Japanese Randomized Trial for Investigation of a Combined Therapy of Amiodarone and Implantable Cardioverter Defibrillator in Patients With Ventricular Tachycardia and Fibrillation : The Nippon ICD Plus Pharmacologic Option Necessity (NIPPON) Study Design
- Clinical Characteristics, Treatment, and Outcome of Tachycardia Induced Cardiomyopathy
- Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy : A Niigata Multicenter Study of DCM
- Primary Concerns during Daily Life in Patients with ICD and their Families (Role of ICD Discharge for Quality of Life)
- Comparison of triggering modes and therapeutic effect of nicorandil for ventricular tachyarrhythmia in canine models of LQT2 and LQT3
- Tridimensional analysis of onset mode and arrhythmogenesis of discordant QT/T alternans in long QT syndrome
- Discrepancy between Inducibility of Ventricular Tachycardia and Activity of Cardiac Sarcoidosis - Requirement of Defibrillator Implantation for the Inactive Stage of Cardiac Sarcoidosis -
- Role of α_1-Blockade in Congenital Long QT Syndrome : Investigation by Exercise Stress Test
- Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulation in Brugada Syndrome
- PJ-692 Role of Faster Pacing and Magnesium (Mg) for the Treatment of Torsade de pointes (Tdp) Associated with Intravenous Amiodarone Administration(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scien
- PJ-688 The Abnormality of QT/RR Relationship in Brugada Syndrome and Idiopathic Ventricular Fibrillation without Prominent J-wave(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of T
- PJ-555 Distribution of Defibrillation Threshold (DFT) in Patients Treated with Implantable Cardioverter-Defibrillators (ICD) : Incidence and Characteristics of High DFT Patients(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Sess
- PJ-089 Characteristics of the Subsequent Recurrence of Ventricular Tachyarrhythmia in Patients under ICD Therapy, Concern of Driving(PJ015,ICD (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-004 Clinical and ECG Characteristics as a Predictor of Recurrence of Ventricular Tachyarrhythmia (VTA) in Patients with Hypertrophic Cardiomyopathy (HCM)(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annua
- PE-105 Exercise-induced QT Interval Prolongation and Its Relation to the Cardiac Events in Long QT Syndrome (LQTS) Carrying KCNQ1-Mutations(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting
- 4 Role of Antiarrhythmic Drugs in Preventing Sudden Cardiac Death(Fighting Cardiac Sudden Death: Efficacy and Future,Roundtable Discussion 8 (RT-8) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 4 Relationship between Drug-Induced QT Prolongation and Bradycardia Dependent QT Prolongation : Usefulness for Risk Factors of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientifi
- Preservation of Renal Function in Response to Cardiac Resynchronization Therapy
- PJ-789 Measurement of defibrillation threshold in the patients treated with implantable cardioverter-defibrillator (ICD)(Arrhythmia, therapy(22)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-694 Indication of ICD treatment as primary prevention of sudden cardiac death in Japanese patients with dilated cardiomyopathy(Heart failure, clinical(19)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- PJ-605 ECG characteristics of the time course of inappropriate ICD shocks due to T-wave double count(Arrhythmia, therapy(21)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-206 Relationship Between Electroanatomical Mapping Characteristics and Optimal Ablation Site in Idiopathic Ventricular Arrhythmia Originated Right Ventricular Outflow Tract Septum(Arrhythmia,diagnosis/Pathophysiology/EPS(13)(A),Poster Session(Japanese)
- OJ-150 Antiarrhythmic Effects of Bepridil to Ventricular Tachyarrhythmias : Focus on the Transmural Dispersion of Repolarization and Sympathetic Nerve Activity(Arrhythmia, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Comparison of Efficacy of Sotalol and Nifekalant for Ventricular Tachyarrhythmias(CLINICAL INVESTIGATION)
- Segmental Conduction Block in a Low-Voltage Area Suppressed Macro-Reentrant Ventricular Tachycardia after Surgical Repair of Tetralogy of Fallot
- Decrease in Amplitude of Intracardiac Ventricular Electrogram and Inappropriate Therapy in Patients With an Implantable Cardioverter Defibrillator
- PJ-294 Shortening of QT Interval by Mexiletine and It's Clinical Use in LQTl and LQT2(Arrhythmia, therapy-19, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-097 Intracoronary Acetylcholine (Ach) Induces a Greater QT Interval Prolongation and Torsade de Points (TdP) in LQT2 Than LQT1(Autonomic nervous system-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-494 Role of Sympathetic Nerve Activity and Therapeutic Effect of Beta-blockers for Polymorphic Ventricular Tachycardia (PVT) in a Canine LQT3 Model(Autonomic nervous system-5 (H) PJ83,Poster Session (Japanese),The 70th Anniversary Annual Scientific Mee
- PE-150 Comparison of Dilated Cardiomyopathy and Coronary Artery Disease in Effectiveness of Dl-sotalol on the Recurrence of Ventricular Tachyarrhythmia(Arrhythmia, therapy-10 (A) PE25,Poster Session (English),The 70th Anniversary Annual Scientific Meeting
- PE-135 Clinical Characteristics and Outcome of Ventricular Tachyarrhythmia Associated with Sarcoidosis : Comparison with Ischemic Heart Disease(Arrhythmia, diagnosis/pathophysiology/EPS-8 (A) PE23,Poster Session (English),The 70th Anniversary Annual Scien
- OJ-376 Incidence and Initial Pattern of Pilsicainide Induced Polymorphic Ventricular Tachycardia (PVT) in Patients with Brugada-like ECG Abnormality(ECG/Body surface potential mapping/Holter-3 (A) OJ63,Oral Presentation (Japanese),The 70th Anniversary Ann
- OJ-375 STJ Normalization by Quinidine was Associated with QT Prolongation in Precordial Lead Due to Restoration of the Phase 2 Dome(ECG/Body surface potential mapping/Holter-3 (A) OJ63,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
- Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias
- Efficacy of Bepridil for Antiarrhythmic Drug Refractory Ventricular Tachyarrhythmias in ICD Patients with Structural Heart Disease(Arrhythmia, Pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Incidence and Predictors of Atrial Fibrillation in Subjects without Structural Heart Disease(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship Between Clinical Characteristics and Conduction Delay in the RVOT in Brugada Syndrome : Investigation of Signal-Averaged ECG in Precordial Leads(ECG/Body Surface Potential Mapping/Holter 2 (A), The 69th Annual Scientific Meeting of the Japane
- Role of Combined Medication Therapy for ICD Patients : Prognosis and ICD Discharge(Sudden Cardiac Death (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Indications for an Implantable Cardioverter Defibrillator (ICD)
- PJ-574 A Novel Missense Mutation (R2401H) in the Human Cardiac Ryanodine Receptor Gene (RyR2) in Patient with Catecholaminergic Polymorphic Ventricular Tachycardia(Arrhythmia, Basic and Diagnosis/Pathophysiology/EPS (A) : PJ96)(Poster Session (Japanese))
- PE-109 The Results of Electrophysiological Study for Nifekalant can Predict the Efficacy of Chronic Sotalol Treatment in Patients with Ventricular Tachyarrhythmia.(Arrhythmia, Pharmacological Therapy 1 (A) : PE19)(Poster Session (English))
- PE-004 Spontaneous Fibrillation Occurs in Rat Fetal Myocytes by Adenovirus Mediated Overexpression of a Voltage-gated Potassium Channel Kv1.5(Arrhythmia, Basic 2 (A) : PE1)(Poster Session (English))
- OJ-429 Antiarrhythmic effects of magnesium sulfate for ventricular tachyarrhythmia developed under the condition of QT interval prolongation(ECG/Body Surface Potential Mapping/Holter 6 (A) : OJ52)(Oral Presentation (Japanese))
- OJ-234 Possibility and Problems to resume driving in patients with Implantable-Cardioverter Defibrillator (ICD) : Estimated risk of future ICD therapy(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A) : OJ27)(Oral Presentation (Japanese))
- Amiodarone Therapy in Patients Implanted With Cardioverter-Defibrillator for Life-Threatening Ventricular Arrhythmias
- Does Amiodarone Therapy Improve the Prognosis of VT/VF Patients after ICD Implantation? NATIVE (Nippon Amiodarone Therapy with ICD Viability Evaluation) Pre-study(Sudden Cardiac Death (A), The 69th Annual Scientific Meeting of the Japanese Circulation Soc
- Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation : Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration
- Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia : Retrospective Case Series
- PE-167 Role of Mineralcorticoid Receptor Antagonist on Atrial Structural Remodeling in Hypertensive Rats(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Evaluation of Candidates of Biventricular Pacing Therapy in Idiopathic Dilated Cardiomyopathy
- RADIOFREQUENCY CURRENT CATHETER ABLATION FOR SUSTAINED VENTRICULAR TACHYCARDIA
- CLINICAL CHARACTERISTICS AND POSSIBLE ROLE OF CORONARY ARTERY SPASM IN SYNCOPE AND/OR ABORTED SUDDEN DEATH
- -0902-ELECTROPHYSIOLOGIC ASSESSMENT OF SUSTAINED VENTRICULAR TACHYCARDIA ASSOCIATED WITH IDIOPATHIC DILATED CARDIOMYOPATHY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0901-ELECTROPHYSIOLOGICAL ABNORMALITIES AT THE REENTRANT CIRCUIT IN SUSTAINED VENTRICULAR TACHYCARDIA : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PJ-201 A Compound Heterozygous Mutation in KCNQ1 Associated with Long QT Syndrome(Arrhythmia, basic(05)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Correlation Between the Effective Refractory Period and Activation-Recovery Interval Calculated From the Intracardiac Unipolar Electrogram of Humans With and Without dl-Sotalol Treatment
- OE-335 Sotalol Treatment is Useful and Safe in Patients with Ventricular Tachyarrhythmias and Left Ventricular Dysfunction(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
- OE-334 Electrocardiographic Effects of Quinidine in Brugada Syndrome : Is It Beneficial or Not?(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
- OE-329 Ventricular tachyarrhytmia developed during treatment with class III antiarrhythmic drugs : arrhythmogenesis of slow heart rate and sympathetic nerve activity(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
- The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment
- OE-139 Impact of Incessant Earthquake on Sudden Death, Acute Coronary Syndrome, Takotsubo Cardiomyopathy, and Pulmonary Embolism : the Niigata Chuetsu Earthquake Study(Preventive medicine/Epidemiology/Education-1 (H) OE24,Oral Presentation (English),The 7
- PJ-049 A Comparison of Dilated Cardiomyopathy with Hypertrophic Cardiomyopathy in Efficacy of Implantable Cardioverter-Defibrillator(Arrhythmia, therapy-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-022 Investigation of Activation Delay After Premature Stimulation in Brugada Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-207 Ca-antagonist Therapy in Brugada Syndrome Patients(Arrhythmia, diagnosis/pathophysiology/EPS-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-221 Role of Cardiac Resynchronization Therapy on Renal Function(Kidney/Renal circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
- Development of Ventricular Fibrillations With Different Characteristics in the Local Electrocardiogram : Large and Small Amplitude of Activation, and its Implication for Implantable Cardioverter Defibrillator Treatment
- OJ-055 Poor Adaptation of QT Interval and Characteristics of Electrocardiographic Parameters of Repolarization in Brugada Syndrome(ECG/Body surface potential mapping/Holter-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 2 Possible Candidate of CRT-D Treatment : From the Analysis of ICD and CRT-P Patients(Indication for CRT-D, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
- Severe Electrical Storm in Patients with Implantable CardioverterDefibrillators (ICD) : Does It Predict Poor Prognosis?
- Long-Term Outcomes of EP-Guided Sotalol Treatment for Sustained Ventricular Tachyarrhythmias
- RADIOFREQUENCY CURRENT CATHETER ABLATION FOR VENTRICULAR TACHYCARDIA
- PROARRHYTHMIC EFFECTS OF ANTIARRHYTHMIC DRUGS ASSESSED BY ELECTROPHYSIOLOGIC STUDY IN RECURRENT SUSTAINED VENTRICULAR TACHYCARDIA
- -0270-RATE ACCELERATION OF VENTRICULAR TACHYCARDIA DURING PHARMACOLOGICAL THERAPY WITH SUCCESSFUL RATE CONTROL
- Non-Pharmacological Management of Ventricular Tachycardia(Ventricular Tachycardia/Fibrillation)
- Metabolic Syndrome and Catheter Ablation in Atrial Fibrillation
- Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia
- Incidence and clinical implications of visible T-wave alternans in Brugada syndrome
- Short- and Long-Term Effects of Excess Thyroid Hormone on L-Type Calcium Channels of Rat Left Ventricles
- Intramural Arrhythmogenesis of ECG Phenomenon of Prolonged QT Interval, Short-Long Cardiac Cycle and T Wave Alternans in Long QT Syndrome
- Arrhythmogenesis of Sympathetic Activity Related Ventricular Tachyarrhythmias in Type 3 Long QT Syndrome (LQT3)
- Demonstration of Transient Entrainment in Monomorphic Sustained Ventricular Tachycardia Associated With Cardiac Sarcoidosis
- Ventricular Tachyarrhythmias in a Canine Model of LQT3 Arrhythmogenic Effects of Sympathetic Activity
- Modulation of gene expression of ionic channels in rat heart by thyroid hormone
- Correlation Between the Effective Refractory Period and Activation-Recovery Interval Calculated From the Intracardiac Unipolar Electrogram of Humans With and Without dl-Sotalol Treatment
- Inappropriate Discharges From an Intravenous Implantable Cardioverter Defibrillator Due to T-Wave Oversensing
- Action of Antiarrhythmic Agents on the Area of Slow Conduction in Ventricular Tachycardia
- ST-T Abnormalities on ECG in Relation to Cardiovascular Risk Factors
- Guidelines for Risks and Prevention of Sudden Cardiac Death (JCS 2010) : Digest Version
- Role of Sotalol and Nifekalant Therapy in Patients with Life-Threatening Ventricular Tachyarrhythmia
- Nicorandil Suppresses a Hump on the Monophasic Action Potential and Torsade de Pointes in a Patient with Idiopathic Long QT Syndrome.
- Alternation in the Fusion Complex during Constant Pacing of Sustained Ventricular Tachycardia.
- Evidence for Slow Conduction Areas during Pacing in Patients with Sinus Rhythm, and their Relation to the Site of VT Origin.
- Fusion with Postpaced Return Cycle Identical to Tachycardia Cycle Length during Transient Entrainment of Ventricular Tachycardia and its Implications.
- Pleomorphic Ventricular Tachycardia Arising from a New Site during Antiarrhythmic Drug Therapy.
- Abrupt Loss of Constant Fusion during Entrainment of Ventricular Tachycardia at a Critical Paced Cycle Length.
- Aortitis syndrome, coronary artery ectasia, and mid-ventricular obstruction.
- Suppression of Fluid Accumulation Following Pericardial Inflammation in a Patient with Primary Chylopericardium.