PROARRHYTHMIC EFFECTS OF ANTIARRHYTHMIC DRUGS ASSESSED BY ELECTROPHYSIOLOGIC STUDY IN RECURRENT SUSTAINED VENTRICULAR TACHYCARDIA

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概要

• 論文の詳細を見る

• Proarrhythmic responses were evaluated in repeated electrophsiologic studies (EPS) in 27 patients with inducible ventricular tachycardia (VT). Class Ia drugs were administered to 23. Ib to 6. Ic to 4. III to 5 and IV to 9 patients. The mean age was 53 years, and 18 patients had structural heart diseases. Pleomorphism was observed in 11 patients. In 4 patients (15%), the VT cycle length (CL) shortened by 50ms or more in EPS during the administration of antiarrhythmic drugs. VT was inducible by a less aggressive induction mode than the control study in 9 patients (33%). In 4 patients (15%), the induced VT changed to the incessant form, and the other 2 patients (7%) required DC shocks due to hemodynamic deterioration. Patients with pleomorphic VT and/or structural heart diseases seemed to develop proarrhythmia more frequently. In total, some proarrhythmic response was observed in 13 (48%) of the 27 patients. Therefore, it should be kept in mind that proarrhythmic effects are frequently observed during antiarrhythmic therapy in patients with sustained VT. The action of the drugs on the slow conduction zone may vary. which may provide a basis for the development of proarrhythmia.

• 社団法人日本循環器学会の論文
• 1991-02-20

著者

• Shibata Akira

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental

• Shibata A

  First Dept Of Internal Medicine

• Shibata A

  Division Of Cardiology Niigata University Graduate School Of Medical & Dental Sciences

• Tamura Makoto

  1st Department Of Internal Medisine Niigata University

• Chinushi Masaomi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Aizawa Y

  Division Of Cardiology Niigata University Graduate School Of Medical And Dental Sciences

• CHINUSHI Masaomi

  the First Department of Internal Medicine, Niigata University School of Medicine

• Minagawa Shiro

  新潟大学 医歯学総合研究科循環器学分野

• Shibata Akira

  The First Department of Internal Medicine, Niigata University School of Medicine

• MIYAJIMA Seiichi

  The First Department of Internal Medicine,Niigata University

• FUNAZAKI Toshikazu

  The First Department of Internal Medicine,Niigata University

• TAMURA Makoto

  The First Department of Internal Medicine,Niigata University

• MIYAJIMA Seiichi

  Institute for Molecular Science

• Shibata Akira

  First Department Of Internal Medicine Niigata University Niigata Case Western Reserve University

• Miyajima Seiichi

  The First Department Of Internal Medicine Niigata University School Of Medicine

• Shibata Akira

  The First Department Of Internal Medicine Niigata University School Of Medicine

• Tamura Makoto

  The First Department Of Internal Medicine Niigata University School Of Medicine

• AIZAWA YOSIFUSA

  The First Department of Internal Medicine, Niigata University School of Medicine

• Aizawa Yoshifusa

  Cardiovascular Medicine Niigata University Graduate School Of Medicine

• Funazaki Toshikazu

  The First Department Of Internal Medicine Niigata University School Of Medicine

• Miyajima S

  Division Of Internal Medicine Niigata Minami Hospital

• Shibata Akira

  The Frist Department Of Internal Medicine Niigata University School Of Medicine

• Shibata Akira

  The 1st. Depertment Of Internal Medicine Niigata University School Of Medicine.

• Chinushi Masaomi

  The First Department of Internal Medicine, Niigata University of Medicine

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