Changes in α_1-and β_1-Adrenergic Receptors and Calcium Ion Binding Sites in the Fetal Myocardium of Spontaneously Hypertensive Rats (SHR)

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The present study examined changes in [^3H] prazosin, [^<125>I] iodocyanopindolol and [^3H] nitrendipine binding to α_1-and β_1-adrenergic receptors and Ca^<2+> binding sites of cardiac muscle isolated from fetal Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), using the radioligand binding assay method. The catecholamine concentration in the cardiac muscle of both groups was also determined. The B_<max> values in β_1-adrenoceptors and Ca^<2+> binding sites in SHR cardiac muscle were lower than those of WKY, but values for SHR α_1-adrenoceptors were higher than those of WKY. The K_d values of β_1-adrenoceptors in cardiac muscles of SHRs were also lower than those of WKY. On the other hand, there were no differences between the catecholamine concentrations in fetal SHR and WKY cardiac muscles. Thus, significant differences in both α_1-and β_1-adrenoceptors and Ca^<2+> binding sites were already present in fetal SHR hearts, thus suggesting that the changes in fetal hearts of SHRs may be caused by genetic defects in the mother rats at early age.
社団法人日本薬学会の論文