Nicorandil Suppresses a Hump on the Monophasic Action Potential and Torsade de Pointes in a Patient with Idiopathic Long QT Syndrome.

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概要

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• The patient was a 71-year-old female with Torsade de Pointes (TdP) associated with idiopathic long QT syndrome. TdP and polymorphic nonsustained VT were frequently observed at bedside and an electrophysiologic study was performed. The QT (and QTU) interval was abnormally prolonged, and alternation of the QT interval was also recorded on the electrocardiogram. Monophasic action potential (MAP) from the right ventricle showed a hump on the falling limb of the MAP following a long RR interval of more than 1.0sec. Intravenous administration of nicorandil (2mg) resulted in disappearance of the hump, and ventricular arrhythmia was no longer observed. The QT interval at a PP interval of 720msec was slightly shortened. She was treated with a DDD-pacemaker and given nicorandil. No recurrence of TdP was observed during the followup period of 8 months. This drug might be effective in patients with idiopathic long QT syndrome.

著者

• Furushima Hiroshi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Chinushi Masaomi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Shibata Akira

  First Department Of Internal Medicine Niigata University Niigata Case Western Reserve University

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• OJIMA Kenji

  Department of Internal Medicine, Shounai Hospital

• INUZUKA Hiroshi

  Department of Internal Medicine, Shounai Hospital

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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