Electrophysiologic Effects of Intravenous MS-551, a Novel Class III Antiarrhythmic Agent, on Human Atrium and Ventricle.

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of intravenous MS-551, a new class III antiarrhythmic drug, on atrium and ventricle were evaluated in 6 patients with ventricular tachyarrhythmias (4 males and 2 females; mean age 45±21 years) in an electrophysiologic study. Two patients had sustained ventricular tachycardia (VT) and 4 patients had ventricular fibrillation (VF). Electrophysiologic study was performed before and after the administration of MS-551 (loading infusion 0.3mg/kg for 5min+0.01mg/kg/min).The QT and QTc intervals were significantly prolonged by MS-551 from 359±52 to 411±63 msec (p=0.01) and from 410±36 to 452±47 (p=0.0172), respectively. No effect was observed on the sinus cycle length, QRS duration, or AH and HV intervals in sinus rhythm.The effective refractory periods of the right atrium (AERP) were significantly prolonged at paced cycle lengths of 600 (from 222±19 to 250±23 msec, p=0.0009), 400 (from 207±15 to 228±15, p<0.0001) and 300 (from 193±10 to 205±8 msec, p=0.0127) msec. Similarly, the right ventricular ERP (VERP) were significantly prolonged at paced cycle lengths of 600 (from 240±23 to 268±23 msec, p<0.0001), 400 (from 225±22 to 250±24 msec, p=0.0007), and 300 msec (from 213±14 to 228±18 msec, p=0.0071). MS-551 prolonged AERP and VERP in a "reverse" use-dependent manner without changing the conduction time in patients with ventricular tachyarrhythmias.MS-551 prevented the induction of VT in 1 patient and VF in only 1 patient in this electrophysiologic study. Further evaluation of the therapeutic potential of MS-551 using higher dosages is necessary.

• International Heart Journal刊行会の論文

著者

• Furushima Hiroshi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Yamaura Masayuki

  First Department Of Internal Medicine Niigata University School Of Medicine

• Tagawa Minoru

  First Department of Internal Medicine, Niigata University School of Medicine

• Naitoh Naoki

  First Department Of Internal Medicine Niigata University School Of Medicine

• Taneda Koji

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Naitoh Naoki

  First Department of Internal Medicine, Niigata University School of Medicine

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

関連論文

• Improved cardiac function after sirolimus-eluting stent placement in diabetic patients by pioglitazone : Combination therapy with statin
• PJ-474 The Effects of Erythropoietin-derivatives on Monocrotaline-induced Pulmonary Hypertension in Rats(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement
• PJ-366 Phase I/II Clinical Study of Angiogenic Therapy by Ex-Vivo Expanded Erythroblast Transplantation (EVEETA) for the Patients with Critical Limb Ischemia(PJ062,Regeneration (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Mee
• PJ-004 Clinical and ECG Characteristics as a Predictor of Recurrence of Ventricular Tachyarrhythmia (VTA) in Patients with Hypertrophic Cardiomyopathy (HCM)(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annua
• Health-Related Quality of Life of Outpatients With Systolic and Isolated Diastolic Dysfunction : Sado Heart Failure Study
• 14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes
• Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin Is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis
• Comparison of Antiarrhythmics Used in Patients With Paroxysmal Atrial Fibrillation : Subanalysis of J-RHYTHM Study
• Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation : J-RHYTHM Study(Arrhythmia/Electrophysiology)
• Randomized Study of Angiotensin II Type 1 Receptor Blocker vs Dihydropiridine Calcium Antagonist for the Treatment of Paroxysmal Atrial Fibrillation in Patients With Hypertension : The J-RHYTHM II Study Design for the Investigation of Upstream Therapy for
• Japanese Randomized Trial for Investigation of a Combined Therapy of Amiodarone and Implantable Cardioverter Defibrillator in Patients With Ventricular Tachycardia and Fibrillation : The Nippon ICD Plus Pharmacologic Option Necessity (NIPPON) Study Design
• Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy : A Niigata Multicenter Study of DCM
• Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulation in Brugada Syndrome
• Pharmacokinetic and pharmacodynamic analysis of cyclosporine A (CsA) to find the best single time point for the monitoring and adjusting of CsA dose using twice-daily 3-h intravenous infusions in allogeneic hematopoietic stem cell transplantation
• Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy
• Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Activator, Suppresses Experimental Autoimmune Myocarditis by Stimulating the Interleukin-10 Pathway in Rats
• OE-389 Clinical Phenotype of Japanese LQT1 Form of Congenital Long QT Syndrome by Location and Coding Type From Japanese Multicenter Registry(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of
• PJ-692 Role of Faster Pacing and Magnesium (Mg) for the Treatment of Torsade de pointes (Tdp) Associated with Intravenous Amiodarone Administration(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scien
• PJ-688 The Abnormality of QT/RR Relationship in Brugada Syndrome and Idiopathic Ventricular Fibrillation without Prominent J-wave(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of T
• PJ-555 Distribution of Defibrillation Threshold (DFT) in Patients Treated with Implantable Cardioverter-Defibrillators (ICD) : Incidence and Characteristics of High DFT Patients(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Sess
• PJ-089 Characteristics of the Subsequent Recurrence of Ventricular Tachyarrhythmia in Patients under ICD Therapy, Concern of Driving(PJ015,ICD (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-105 Exercise-induced QT Interval Prolongation and Its Relation to the Cardiac Events in Long QT Syndrome (LQTS) Carrying KCNQ1-Mutations(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting
• 4 Role of Antiarrhythmic Drugs in Preventing Sudden Cardiac Death(Fighting Cardiac Sudden Death: Efficacy and Future,Roundtable Discussion 8 (RT-8) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 4 Relationship between Drug-Induced QT Prolongation and Bradycardia Dependent QT Prolongation : Usefulness for Risk Factors of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientifi
• Preservation of Renal Function in Response to Cardiac Resynchronization Therapy
• PJ-789 Measurement of defibrillation threshold in the patients treated with implantable cardioverter-defibrillator (ICD)(Arrhythmia, therapy(22)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Saphenous Vein Graft Shrinkage as a Mechanism of Stenosis Soon After Bypass Surgery
• PJ-294 Shortening of QT Interval by Mexiletine and It's Clinical Use in LQTl and LQT2(Arrhythmia, therapy-19, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-097 Intracoronary Acetylcholine (Ach) Induces a Greater QT Interval Prolongation and Torsade de Points (TdP) in LQT2 Than LQT1(Autonomic nervous system-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias
• Relationship Between Clinical Characteristics and Conduction Delay in the RVOT in Brugada Syndrome : Investigation of Signal-Averaged ECG in Precordial Leads(ECG/Body Surface Potential Mapping/Holter 2 (A), The 69th Annual Scientific Meeting of the Japane
• Role of Combined Medication Therapy for ICD Patients : Prognosis and ICD Discharge(Sudden Cardiac Death (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-429 Antiarrhythmic effects of magnesium sulfate for ventricular tachyarrhythmia developed under the condition of QT interval prolongation(ECG/Body Surface Potential Mapping/Holter 6 (A) : OJ52)(Oral Presentation (Japanese))
• Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury
• Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
• OE-225 Guidelines for Chronic Deep Vein Thrombosis/Pulmonary Embolism (DVT/PE) in Mid Niigata Prefecture Earthquake 2004(Thromboembolism/Antithrombotic therapy/Thrombolysis-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Atrial Fibrillation Revisited : With a Special Reference to Primary Prevention
• Acute Pulmonary Thromboembolism Induced by Prophylactic Heparin Use and a Heparin-Coated Catheter : A Case of Heparin-Induced Thrombocytopenia and Thrombosis Syndrome
• Regulation of Endothelial Nitric Oxide Synthase and Endothelin-1 Expression by Fluvastatin in Human Vascular Endothelial Cells
• The Usefulness of Holter Monitoring in Selecting Pharmacologic Therapy for Patients With Sustained Monomorphic Ventricular Tachycardia : Studies in Patients in Whom No Effective Pharmacologic Therapy Could be Determined by Electrophysiologic Study
• NET Na/K FLUX RATIO IN THE ERYTHROCYTE OF JAPANESE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Hypertension
• Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation : Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration
• Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia : Retrospective Case Series
• Sequential adenovirus infection of type 14 hemorrhagic cystitis and type 35 generalized infection after cord blood transplantation
• Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction
• PJ-525 MPO and MPO-ANCA in Coronary Artery Circulation(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-353 Comparative Effects of Torasemide and Furosemide in Rats with Chronic Heart Hailure after Autoimmune Myocarditis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-167 Role of Mineralcorticoid Receptor Antagonist on Atrial Structural Remodeling in Hypertensive Rats(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-103 Clinical Phenotype of Japanese LQT3 Form of Congenital Long QT Syndrome by Location of Mutation from Japanese Multicenter Registry(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting o
• FRS-117 Clinical and Electrocardiographic Characteristics of Japanese Probands with Brugada Syndrome with an SCN5A Mutation from Japanese Multicenter Registry(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73r
• PJ-208 Impact of Frameshift Mutation and Nonsense-mediated mRNA Decay on Clinical Phenotype in LQT2 Form of Congenital Long QT Syndrome(Arrhythmia,diagnosis/Pathophysiology/EPS(13)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japa
• The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia
• PE-415 Different Response to Exercise Testing between LQT7 Form of Congenital Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia(Exercise test/Cardiac rehabilitation(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting
• OJ-146 Lipocalin-2 a New Biomarker of Inflammatory Heart Disease?(OJ25,Myocarditis, Basic/ Clinical (M),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• -P155- Evaluation of Ventricular Vulnerability during Atrial Defibrillation through Implanted Transvenous Catheters in The Sterile Pericarditis Model(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• RADIOFREQUENCY CURRENT CATHETER ABLATION FOR SUSTAINED VENTRICULAR TACHYCARDIA
• Requirements of Non-pharmacologic Interventions in the Treatmrnt of Recurrent Sustained Ventricular Tachycardia : 53th Annual Scientific Session of the Japanese Circulation Society
• CONDUCTION THROUGH THE REENTRANT CIRCUIT IN RECURRENT SUSTAINED VENTRICULAR TACHYCARDIA EVALUATED BY USE OF TRANSIENT ENTRAINMENT
• Involvement of Mast Cells in the Development of Fibrosis in Rats with Postmyocarditis Dilated Cardiomyopathy(Miscellaneous)
• Inactivation of 14-3-3 Protein Exacerbates Cardiac Hypertrophy and Fibrosis through Enhanced Expression of Protein Kinase C β2 in Experimental Diabetes(Biochemistry/Molecular Biology)
• Expression of the TCL1 Gene at 14q32 in B-Cell Malignancies but Not in Adult T-Cell Leukemia
• High-Sensitivity CRP Reflects Insulin Resistance in Smokers
• VENTRICULAR TACHYCARDIA WITH TWO POSSIBLE EXITS FROM ONE RE-ENTRANT CIRCUIT
• OE-329 Ventricular tachyarrhytmia developed during treatment with class III antiarrhythmic drugs : arrhythmogenesis of slow heart rate and sympathetic nerve activity(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
• The Efficacy of DL-Sotalol in Reentrant Ventricular Tachycardia with Special Reference to the Width of the Zone of Entrainment
• Suppression of Myocardial Inflammation Using Suramin, A Growth Factor Blocker
• Changes in the Occurrence of Mechanical Alternans After Long-Term β-Blocker Therapy in Patients With Chronic Heart Failure
• Abnormal fatty acid matabolism in patients with coronary vasospasm
• Electrophysiologic Parameters to Predict Clinical Recurrence of Ventricular Tachycardia in Patients Under Electrophysiologic Study-Guided Effective Pharmacological Therapy
• PJ-049 A Comparison of Dilated Cardiomyopathy with Hypertrophic Cardiomyopathy in Efficacy of Implantable Cardioverter-Defibrillator(Arrhythmia, therapy-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
• Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
• Severe Electrical Storm in Patients with Implantable CardioverterDefibrillators (ICD) : Does It Predict Poor Prognosis?
• Long-Term Outcomes of EP-Guided Sotalol Treatment for Sustained Ventricular Tachyarrhythmias
• RADIOFREQUENCY CURRENT CATHETER ABLATION FOR VENTRICULAR TACHYCARDIA
• Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia
• Intramural Arrhythmogenesis of ECG Phenomenon of Prolonged QT Interval, Short-Long Cardiac Cycle and T Wave Alternans in Long QT Syndrome
• Arrhythmogenesis of Sympathetic Activity Related Ventricular Tachyarrhythmias in Type 3 Long QT Syndrome (LQT3)
• Ventricular Tachyarrhythmias in a Canine Model of LQT3 Arrhythmogenic Effects of Sympathetic Activity
• Effects of Class I and III Antiarrhythmic Drugs on Ventricular Tachycardia-Interrupting Critical Paced Cycle Length With Rapid Pacing
• Correlation Between the Effective Refractory Period and Activation-Recovery Interval Calculated From the Intracardiac Unipolar Electrogram of Humans With and Without dl-Sotalol Treatment
• Inappropriate Discharges From an Intravenous Implantable Cardioverter Defibrillator Due to T-Wave Oversensing
• Magnesium Treatment for Drug-Induced QT Prolongation
• A Comparison of Electrophysiologic Properties between Responders and Non-responders to DL-sotalol among Patients with Ventricular Tachyarrhythmia. Importance of the Lack of a Reverse Use-dependent Effect on Ventricular Refractoriness to Responders. : Impo
• Use-dependent Electrophysiologic Effects of DL-sotalol and Modulation by Isoproterenol in the Human Ventricle.
• Role of Sotalol and Nifekalant Therapy in Patients with Life-Threatening Ventricular Tachyarrhythmia
• Nicorandil Suppresses a Hump on the Monophasic Action Potential and Torsade de Pointes in a Patient with Idiopathic Long QT Syndrome.
• Comparison of Electrophysiologic Effects of Intravenous E-4031 and MS-551, Novel Class III Antiarrhythmic Agents, in Patients with Ventricular Tachyarrhythmias.
• Procainamide-Induced Changes in Reentrant Ventricular Tachycardia with Special Reference to the Tachycardia-Interrupting Critical Paced Cycle Length during Transient Entrainment with Rapid Pacing.
• Pleomorphic Ventricular Tachycardia Arising from a New Site during Antiarrhythmic Drug Therapy.
• Importance of Retrograde Atrial Activation in Atrial Fibrillation Genesis in the Initiation of Atrial Fibrillation in Wolff-Parkinson-White Syndrome. Comparison of Atrial Electrophysiologic Parameters between Patients with Different Atrial Fibrillation Ge
• Abrupt Loss of Constant Fusion during Entrainment of Ventricular Tachycardia at a Critical Paced Cycle Length.
• Reentrant Ventricular Tachycardia. Interpretations of Electrophysiologic Findings and Its Applications.:Interpretations of Electrophysiologic Findings and Its Applications
• Electrophysiologic Effects of Intravenous MS-551, a Novel Class III Antiarrhythmic Agent, on Human Atrium and Ventricle.
• Intracoronary Acetylcholine-induced Prolongation of Monophasic Action Potential in Long QT Syndrome.
• Both Low and High Energy Cardioversion Induced Accelerated Ventricular Tachycardia in a Patient Treated with an Implantable Cardioverter Defibrillator.
• Ventricular Fibrillation with Small Amplitude of Activation and its Implications for Implantable Cardioverter Defibrillator Treatment.
• Comparative Electrophysiologic Findings between Responders and Nonresponders to Class III Antiarrhythmic Drugs among Patients with Ventricular Tachyarrhythmia.

もっと見る 閉じる

スポンサーリンク