Intracoronary Acetylcholine-induced Prolongation of Monophasic Action Potential in Long QT Syndrome.

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概要

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• Two patients with long QT syndrome, who had episodes of syncope, underwent recordings of the monophasic action potential (MAP) from the right ventricle. Intracoronary administration of acetylcholine (ACh) induced prolongation of MAP duration and caused Torsade de Pointes (Tdp) in both patients. In one patient, intravenous atropine administration did not induce any change in MAP duration. In the other patient, ACh was administered after atropine. According to the results of the present study, abnormal regulation of the muscarinic receptor-mediated K-channel may be involved in the mechanism causing prolongation of MAP duration caused by ACh administration.

• International Heart Journal刊行会の論文

著者

• Furushima Hiroshi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Chinushi Masaomi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Fujita Satoru

  First department of internal medicine, Niigata University School of Medicine

• Niwano Shinichi

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Ohhira Kouji

  First Department Of Internal Medicine Niigata University School Of Medicine

• Taneda Koji

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• SHIBA Masami

  First Department of Internal Medicine, Niigata University School of Medicine

• Abe Akira

  First Department Of Internal Medicine Niigata University School Of Medicine

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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