Effects of Class I and III Antiarrhythmic Drugs on Ventricular Tachycardia-Interrupting Critical Paced Cycle Length With Rapid Pacing

スポンサーリンク

概要

• 論文の詳細を見る

• The most common mechanism of sustained ventricular tachycardia (VT) is re-entry with an excitable gap, but the electrophysiologic properties and response to antiarrhythmic drugs in the area of slow conduction are not yet fully known. The purpose of this study was to assess the effects of a class I antiarrhythmic drug (procainamide) and class III agents (amiodarone, E-4031, and MS-551) on re-entrant VT using the width of the zone of entrainment. The cycle length (CL) of VT (VTCL), the block CL that was the longest paced CL that interrupted the VT, and the width of the zone of entrainment, defined as the difference between VTCL and block CL, were compared before and after treatment with antiarrhythmic drugs. The VTCL was prolonged significantly from 308±63 to 410±77 msec after procainamide (p<0.005) but was not changed after the administration of the class III agents: from 294±50 to 292±13 msec after amiodarone, and from 305±47 to 313±31 msec after E-4031 or MS-551 (p=NS). The block CL was prolonged from 255±61 to 331±70 msec after procainamide (p<0.01), from 256±20 to 260±25 msec after amiodarone, and unchanged after E-4031 or MS-551 (253±31 msec before and 270±43 msec after)(p=NS). The width of the zone of entrainment as a representative of the width of the excitable gap was changed from 52±26 to 79±35 msec (p<0.05) after procainamide, whereas it was unchanged after amiodarone (48±7 msec before and 43±7 msec after) and after E-4031 or MS-551 (50±10 msec before and 40±9 msec after). Therefore, amiodarone, E-4031, and MS-551 did not affect VTCL and block CL whereas procainamide increased these parameters. The excitable gap substituting as the zone of entrainment was increased by procainamide but slightly reduced by amiodarone, E-4031, and MS-551. The effects of these antiarrhythmic drugs on the excitable gap of re-entrant VT were variable and should be examined further.

• 社団法人日本循環器学会の論文
• 1998-03-20

著者

• Washizuka Takashi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Takahashi Kazuyoshi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Aizawa Yoshifusa

  Cardiovascular Medicine Niigata University Graduate School Of Medicine

• Naitoh Naoki

  First Department Of Internal Medicine Niigata University School Of Medicine

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• WASHIZUKA Takashi

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

関連論文

• Improved cardiac function after sirolimus-eluting stent placement in diabetic patients by pioglitazone : Combination therapy with statin
• PJ-474 The Effects of Erythropoietin-derivatives on Monocrotaline-induced Pulmonary Hypertension in Rats(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement
• PJ-366 Phase I/II Clinical Study of Angiogenic Therapy by Ex-Vivo Expanded Erythroblast Transplantation (EVEETA) for the Patients with Critical Limb Ischemia(PJ062,Regeneration (Basic, Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Mee
• PJ-724 Asialoerythropoietin showed cardioprotective effects on ischemia-reperfusion injury model in mouse(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
• PJ-169 Intravenous erythropoietin administration attenuated monocrotaline-induced rat pulmonary hypertension(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-122 Ex Vivo Expanded Erythroblast-Transplantation (Autologous) Therapy, EVEETA, a Novel Remedy for Severe Limb Ischemia.(Regeneration(angiogenesis / myocardial regeneration)(02)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the
• リフラクトリーセラミックファイバー2.0mgの気管内投与による肺内滞留性に関する研究
• 人工脳硬膜の安全性評価に関する研究(第2報) : 人工硬膜埋め込みラットの行動学試験を用いた神経毒性評価
• 環境医学の夢と現実
• トナーの健康影響 (マテリアルスポット 毒性の強いナノ粒子と弱いナノ粒子,体内沈着までの挙動 ナノ粒子の吸引・毒性問題の最新の動き,対策手法のポイント)
• 助成論文 わが国の医療機関における産業保健活動の現状
• PJ-004 Clinical and ECG Characteristics as a Predictor of Recurrence of Ventricular Tachyarrhythmia (VTA) in Patients with Hypertrophic Cardiomyopathy (HCM)(PJ001,Arrhythmia, Others (Clinical/Pathophysiology) 1 (A),Poster Session (Japanese),The 73rd Annua
• Health-Related Quality of Life of Outpatients With Systolic and Isolated Diastolic Dysfunction : Sado Heart Failure Study
• Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin Is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis
• Comparison of Antiarrhythmics Used in Patients With Paroxysmal Atrial Fibrillation : Subanalysis of J-RHYTHM Study
• Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation : J-RHYTHM Study(Arrhythmia/Electrophysiology)
• Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy : A Niigata Multicenter Study of DCM
• Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulation in Brugada Syndrome
• Pharmacokinetic and pharmacodynamic analysis of cyclosporine A (CsA) to find the best single time point for the monitoring and adjusting of CsA dose using twice-daily 3-h intravenous infusions in allogeneic hematopoietic stem cell transplantation
• Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy
• Fenofibrate, a Peroxisome Proliferator-Activated Receptor α Activator, Suppresses Experimental Autoimmune Myocarditis by Stimulating the Interleukin-10 Pathway in Rats
• OE-389 Clinical Phenotype of Japanese LQT1 Form of Congenital Long QT Syndrome by Location and Coding Type From Japanese Multicenter Registry(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of
• FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
• PJ-692 Role of Faster Pacing and Magnesium (Mg) for the Treatment of Torsade de pointes (Tdp) Associated with Intravenous Amiodarone Administration(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scien
• PJ-688 The Abnormality of QT/RR Relationship in Brugada Syndrome and Idiopathic Ventricular Fibrillation without Prominent J-wave(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of T
• PJ-555 Distribution of Defibrillation Threshold (DFT) in Patients Treated with Implantable Cardioverter-Defibrillators (ICD) : Incidence and Characteristics of High DFT Patients(PJ093,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) 2 (A),Poster Sess
• PJ-089 Characteristics of the Subsequent Recurrence of Ventricular Tachyarrhythmia in Patients under ICD Therapy, Concern of Driving(PJ015,ICD (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-105 Exercise-induced QT Interval Prolongation and Its Relation to the Cardiac Events in Long QT Syndrome (LQTS) Carrying KCNQ1-Mutations(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting
• 4 Role of Antiarrhythmic Drugs in Preventing Sudden Cardiac Death(Fighting Cardiac Sudden Death: Efficacy and Future,Roundtable Discussion 8 (RT-8) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 4 Relationship between Drug-Induced QT Prolongation and Bradycardia Dependent QT Prolongation : Usefulness for Risk Factors of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientifi
• Preservation of Renal Function in Response to Cardiac Resynchronization Therapy
• PJ-789 Measurement of defibrillation threshold in the patients treated with implantable cardioverter-defibrillator (ICD)(Arrhythmia, therapy(22)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-694 Indication of ICD treatment as primary prevention of sudden cardiac death in Japanese patients with dilated cardiomyopathy(Heart failure, clinical(19)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-605 ECG characteristics of the time course of inappropriate ICD shocks due to T-wave double count(Arrhythmia, therapy(21)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-206 Relationship Between Electroanatomical Mapping Characteristics and Optimal Ablation Site in Idiopathic Ventricular Arrhythmia Originated Right Ventricular Outflow Tract Septum(Arrhythmia,diagnosis/Pathophysiology/EPS(13)(A),Poster Session(Japanese)
• Comparison of Efficacy of Sotalol and Nifekalant for Ventricular Tachyarrhythmias(CLINICAL INVESTIGATION)
• Lipoprotein(a), Left Atrial Appendage Function and Thromboembolic Risk in Patients With Chronic Nonvalvular Atrial Fibrillation
• PJ-294 Shortening of QT Interval by Mexiletine and It's Clinical Use in LQTl and LQT2(Arrhythmia, therapy-19, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-097 Intracoronary Acetylcholine (Ach) Induces a Greater QT Interval Prolongation and Torsade de Points (TdP) in LQT2 Than LQT1(Autonomic nervous system-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-494 Role of Sympathetic Nerve Activity and Therapeutic Effect of Beta-blockers for Polymorphic Ventricular Tachycardia (PVT) in a Canine LQT3 Model(Autonomic nervous system-5 (H) PJ83,Poster Session (Japanese),The 70th Anniversary Annual Scientific Mee
• PE-150 Comparison of Dilated Cardiomyopathy and Coronary Artery Disease in Effectiveness of Dl-sotalol on the Recurrence of Ventricular Tachyarrhythmia(Arrhythmia, therapy-10 (A) PE25,Poster Session (English),The 70th Anniversary Annual Scientific Meeting
• PE-135 Clinical Characteristics and Outcome of Ventricular Tachyarrhythmia Associated with Sarcoidosis : Comparison with Ischemic Heart Disease(Arrhythmia, diagnosis/pathophysiology/EPS-8 (A) PE23,Poster Session (English),The 70th Anniversary Annual Scien
• OJ-376 Incidence and Initial Pattern of Pilsicainide Induced Polymorphic Ventricular Tachycardia (PVT) in Patients with Brugada-like ECG Abnormality(ECG/Body surface potential mapping/Holter-3 (A) OJ63,Oral Presentation (Japanese),The 70th Anniversary Ann
• OJ-375 STJ Normalization by Quinidine was Associated with QT Prolongation in Precordial Lead Due to Restoration of the Phase 2 Dome(ECG/Body surface potential mapping/Holter-3 (A) OJ63,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
• Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias
• Efficacy of Bepridil for Antiarrhythmic Drug Refractory Ventricular Tachyarrhythmias in ICD Patients with Structural Heart Disease(Arrhythmia, Pharmacological Therapy 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Incidence and Predictors of Atrial Fibrillation in Subjects without Structural Heart Disease(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Relationship Between Clinical Characteristics and Conduction Delay in the RVOT in Brugada Syndrome : Investigation of Signal-Averaged ECG in Precordial Leads(ECG/Body Surface Potential Mapping/Holter 2 (A), The 69th Annual Scientific Meeting of the Japane
• Role of Combined Medication Therapy for ICD Patients : Prognosis and ICD Discharge(Sudden Cardiac Death (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Indications for an Implantable Cardioverter Defibrillator (ICD)
• PJ-574 A Novel Missense Mutation (R2401H) in the Human Cardiac Ryanodine Receptor Gene (RyR2) in Patient with Catecholaminergic Polymorphic Ventricular Tachycardia(Arrhythmia, Basic and Diagnosis/Pathophysiology/EPS (A) : PJ96)(Poster Session (Japanese))
• PE-109 The Results of Electrophysiological Study for Nifekalant can Predict the Efficacy of Chronic Sotalol Treatment in Patients with Ventricular Tachyarrhythmia.(Arrhythmia, Pharmacological Therapy 1 (A) : PE19)(Poster Session (English))
• PE-004 Spontaneous Fibrillation Occurs in Rat Fetal Myocytes by Adenovirus Mediated Overexpression of a Voltage-gated Potassium Channel Kv1.5(Arrhythmia, Basic 2 (A) : PE1)(Poster Session (English))
• OJ-429 Antiarrhythmic effects of magnesium sulfate for ventricular tachyarrhythmia developed under the condition of QT interval prolongation(ECG/Body Surface Potential Mapping/Holter 6 (A) : OJ52)(Oral Presentation (Japanese))
• OJ-234 Possibility and Problems to resume driving in patients with Implantable-Cardioverter Defibrillator (ICD) : Estimated risk of future ICD therapy(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A) : OJ27)(Oral Presentation (Japanese))
• Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury
• A rare case of Graves' disease during regular hemodialysis
• Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
• OE-225 Guidelines for Chronic Deep Vein Thrombosis/Pulmonary Embolism (DVT/PE) in Mid Niigata Prefecture Earthquake 2004(Thromboembolism/Antithrombotic therapy/Thrombolysis-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Atrial Fibrillation Revisited : With a Special Reference to Primary Prevention
• BAFF Is Expressed on Human Platelets and Upregulated by Activation
• DIFFERENT RESPONSE OF LEFT VENTRICULAR DIMENSIONS TO NITROGLYCERIN IN PATIENTS WITH ARTIFICIAL PACEMAKER : A POSSIBLE SIGNIFICANCE OF REFLEX TACHYCARDIA FOR THE REDUCTION OF LV CAVITY AFTER NITROGLYCERIN
• MODIFICATION OF HEMODYNAMIC CHANGES BY HEART RATE FOLLOWING NITROGLYCERIN ADMINISTRATION-ECHOCARDIOGRAPHICAL STUDY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiovascular Drugs (II)
• Effect of Bepridil in Atrial Fibrillation Inducibility Facilitated by Vagal Nerve Stimulation : Prevention of Vagal Nerve Activation-Induced Shortening of the Atrial Action Potential Duration
• Efficacy of Procainamide and Lidocaine in Terminating Sustained Monomorphic Ventricular Tachycardia : Retrospective Case Series
• Sequential adenovirus infection of type 14 hemorrhagic cystitis and type 35 generalized infection after cord blood transplantation
• Serum Hepcidin-20 is Elevated during the Acute Phase of Myocardial Infarction
• PJ-525 MPO and MPO-ANCA in Coronary Artery Circulation(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-353 Comparative Effects of Torasemide and Furosemide in Rats with Chronic Heart Hailure after Autoimmune Myocarditis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-167 Role of Mineralcorticoid Receptor Antagonist on Atrial Structural Remodeling in Hypertensive Rats(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 2 Evaluation of the Prospective Observation of Erythropoietin-Administration for the Treatment of Acute Myocardial Infarction (EPO-AMI)(Late Breaking Clinical Trials II,The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-103 Clinical Phenotype of Japanese LQT3 Form of Congenital Long QT Syndrome by Location of Mutation from Japanese Multicenter Registry(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting o
• RADIOFREQUENCY CURRENT CATHETER ABLATION FOR SUSTAINED VENTRICULAR TACHYCARDIA
• OE-335 Sotalol Treatment is Useful and Safe in Patients with Ventricular Tachyarrhythmias and Left Ventricular Dysfunction(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
• OE-329 Ventricular tachyarrhytmia developed during treatment with class III antiarrhythmic drugs : arrhythmogenesis of slow heart rate and sympathetic nerve activity(Arrhythmia, Pharmacological Therapy 4 (A): OE42)(Oral Presentation (English))
• Inappropriate Discharges by Fourth Generation Implantable Cardioverter Defibrillators in Patients With Ventricular Arrhythmias
• Development of Ventricular Fibrillations With Different Characteristics in the Local Electrocardiogram : Large and Small Amplitude of Activation, and its Implication for Implantable Cardioverter Defibrillator Treatment
• Difference in Ventricular Fibrillation interval between Structural Heart Disease and Brugada Syndrome : Role of Sotalol Treatmentand Defibrillation Threshold
• Severe Electrical Storm in Patients with Implantable CardioverterDefibrillators (ICD) : Does It Predict Poor Prognosis?
• Long-Term Outcomes of EP-Guided Sotalol Treatment for Sustained Ventricular Tachyarrhythmias
• RADIOFREQUENCY CURRENT CATHETER ABLATION FOR VENTRICULAR TACHYCARDIA
• Clinical characteristics of patients with inappropriate implantable cardioverter defibrillator(ICD)therapies : indication for dual-chamber ICD for sinus tachycardia
• Intramural Arrhythmogenesis of ECG Phenomenon of Prolonged QT Interval, Short-Long Cardiac Cycle and T Wave Alternans in Long QT Syndrome
• Arrhythmogenesis of Sympathetic Activity Related Ventricular Tachyarrhythmias in Type 3 Long QT Syndrome (LQT3)
• Demonstration of Transient Entrainment in Monomorphic Sustained Ventricular Tachycardia Associated With Cardiac Sarcoidosis
• Ventricular Tachyarrhythmias in a Canine Model of LQT3 Arrhythmogenic Effects of Sympathetic Activity
• Effects of Class I and III Antiarrhythmic Drugs on Ventricular Tachycardia-Interrupting Critical Paced Cycle Length With Rapid Pacing
• Correlation Between the Effective Refractory Period and Activation-Recovery Interval Calculated From the Intracardiac Unipolar Electrogram of Humans With and Without dl-Sotalol Treatment
• Inappropriate Discharges From an Intravenous Implantable Cardioverter Defibrillator Due to T-Wave Oversensing
• Intracoronary Acetylcholine-Induced Prolongation of the QT Interval and Torsade des Pointes in Long QT Interval Syndrome
• Role of Sotalol and Nifekalant Therapy in Patients with Life-Threatening Ventricular Tachyarrhythmia
• Evidence for Slow Conduction Areas during Pacing in Patients with Sinus Rhythm, and their Relation to the Site of VT Origin.
• Fusion with Postpaced Return Cycle Identical to Tachycardia Cycle Length during Transient Entrainment of Ventricular Tachycardia and its Implications.
• Procainamide-Induced Changes in Reentrant Ventricular Tachycardia with Special Reference to the Tachycardia-Interrupting Critical Paced Cycle Length during Transient Entrainment with Rapid Pacing.
• Abrupt Loss of Constant Fusion during Entrainment of Ventricular Tachycardia at a Critical Paced Cycle Length.
• Beneficial Effect of Amiodarone on Pacing Induced Terminability of Reentrant Ventricular Tachycardia.
• Polymorphisms of Tumor Necrosis Factor-.ALPHA. and Interleukin-10 Genes in Japanese Patients with Idiopathic Dilated Cardiomyopathy.
• Both Low and High Energy Cardioversion Induced Accelerated Ventricular Tachycardia in a Patient Treated with an Implantable Cardioverter Defibrillator.
• Comparative Electrophysiologic Findings between Responders and Nonresponders to Class III Antiarrhythmic Drugs among Patients with Ventricular Tachyarrhythmia.

もっと見る 閉じる

スポンサーリンク