Intracoronary Acetylcholine-Induced Prolongation of the QT Interval and Torsade des Pointes in Long QT Interval Syndrome

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概要

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• A 75-year-old female had syncopal episodes from Torsade des Pointes (TdP). Her electrocardiogram showed a prolonged QT interval which was not associated with electrolyte imbalances or drug therapy. Similar electrocardio-graphic abnormalities were found in three family members. Electrophysiologic study showed a mildly prolonged effective refractory period of 260-290msec, but no tachyarrhythmia was induced. Coronary arteriography was normal but intracoronary acetylcholine unexpectedly induced a prolongation of the QT interval and TdP. Direct action of acetylcholine on the ventricular muscle was suggested.

著者

• Washizuka Takashi

  First Department Of Internal Medicine Niigata University School Of Medicine

• Matsubara Taku

  First Department of Internal Medicine

• Shibata Akira

  First Department Of Internal Medicine Niigata University Niigata Case Western Reserve University

• Igarashi Yutaka

  First Department Of Internal Medicine Niigata University School Of Medicine

• Aizawa Yoshifusa

  First Department Of Internal Medicine Niigata Universaity School Of Medicine

• UCHIYAMA Hirohide

  First Department of Internal Medicine, Niigata University School of Medicine

• HIGUCHI Koutarou

  First Department of Internal Medicine, Niigata University School of Medicine

• TAMURA Yuhsuke

  First Department of Internal Medicine, Niigata University School of Medicine

• WASHIZUKA Takashi

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

• AIZAWA Yoshifusa

  First Department of Internal Medecine, Niigata University School of Medicine, Niigata, Japan.

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