Beneficial Effect of Troglitazone, an Insulin-Sensitizing Antidiabetic Agent, on Coronary Circulation in Patients With Non-Insulin-Dependent Diabetes Mellitus
スポンサーリンク
概要
- 論文の詳細を見る
Evidence is increasing for small vessel remodeling and disturbance of endothelium-dependent vasodilation in diabetic patients. Insulin increases vascular wall thickening and produces endothelial dysfunction. Troglitazone, a new insulin-sensitizer antidiabetic agent, is considered to reduce plasma insulin level and the present study assessed its effect on the coronary circulation of the patients with non-insulin-dependent diabetes mellitus (NIDDM). Analysis of the myocardial washout rate with adenosine triphosphate-stress thallium-201 scintigraphy was used to estimate coronary circulation, and for estimation of insulin sensitivity, the homeostasis model insulin resistance index (HOMA-R) was calculated. Patients were treated with monotherapy of either troglitazone (200 mg bid, n=12) or glibenclamide (2.5 mg dally, n=12) for 3 months. Age-, sex- and risk factors-matched subjects without NIDDM were employed as a control. Fasting plasma glucose and hemoglobin A_<lc> were similarly decreased by troglitazone or glibenclamide. Plasma insulin level (pmol/L) decreased from 66.6±10.8 to 39.0±7.2 with troglitazone, but was unchanged by glibenclamide (58.8±7.2 to 66.0±10.8). The diabetic groups had a significantly lower washout rate than controls, which was improved by troglitazone, but not by glibenclamide. In addition, the increase in washout rate correlated significantly with the decrease in HOMA-R in the troglitazone group. In conclusion, troglitazone can restore coronary circulation by improving insulin resistance in patients with NIDDM. (Jpn Circ J 2001; 65: 487-490)
- 社団法人日本循環器学会の論文
- 2001-05-20
著者
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SUZUKI Jun
Department of Health Care Chemistry, College of Environmental Health, Azabu University
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Watanabe Kouki
Division Of Cardiology Uwajima City Hospital
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Watanabe Kouki
Uwashima City Hospital
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Watanabe Kouki
Department Of Biofunctional Science Faculty Of Agriculture And Life Science Hirosaki University
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Funada Junichi
Department of Cardiology, NHO Ehime National Hospital
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Sekiya Michihito
Department of Cardiology, Ehime National Hospital
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Otani Takashi
Department of Cardiology, Ehime National Hospital
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Akutsu Hiroshi
Department of Cardiology, Ehime National Hospital
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Watanabe Kouki
Saiseikai Matsuyama Hospital
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Suzuki Jun
Department Of Cardiovascular Medicine Tohoku University Graduate School Of Medicine
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Otani Takashi
Department Of Cardiology Ehime National Hospital
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Funada Junichi
Department Of Cardiology Ehime National Hospital
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Funada Jun-ichi
Department Of Cardiology Saiseikai Saijo Hospital
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Sekiya Michihito
Department Of Cardiology Ehime Hospital
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Sekiya Michihito
Department Of Cardiology Ehime Natinal Hospital
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Akutsu Hiroshi
Department Of Cardiology Ehime National Hospital
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Funada Junnichi
Department Of Cardiology Ehime National Hospital
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Watanabe Kouki
Department Of Cardilogy Uwajima City Hospital
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Otani Takashi
Department Of Agricultural Chemistry Kyushu University
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Funada Junichi
Department Of Cardiology Ehime National Hispital
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Suzuki Jun
Department Of Cardiology Saiseikai Saijo Hospital
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