Postprandial Elevation of Remnant Lipoprotein Leads to Endothelial Dysfunction
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概要
- 論文の詳細を見る
Recent studies have demonstrated that elevated levels of cholesterol in the form of remnant-like particles (RLP-C) induce deterioration of endothelial function during the fasting state, but it is not known whether postprandial RLP-C elevation has the same effect. The objective of this study was to assess the effect of postprandial RLP-C elevation on endothelial function in 24 fasting normolipidemic subjects. Flow-mediated dilatation (FMD) during reactive hyperemia in the brachial artery was investigated. Serum lipids and lipoproteins during fasting and 4h after regular fat-loading were measured. Subjects were divided into 2 groups : the high responders (postprandial RLP-C level >7.5mg/dl, n=8) and the normal responders (postprandial RLP-C level ≤7.5mg/dl, n=16). Significant increases in the level of both triglycerides and RLP-C were observed in the high responders. Basal FMD in the high responders (4.3±3.0%) was significantly lower than that in the normal responders (8.3±2.4%) (p<0.01), but FMD after the fat-loading in both groups did not change significantly. The change in RLP-C levels during the fat-loading test correlated significantly with basal FMD (r=-0.588,p<0.01). Multiple regression analysis showed a significant correlation between basal FMD and the change in RLP-C levels (r=-0.488,p<0.02). The results of this study suggest that postprandial RLP-C elevation could be associated with atherosclerotic progression even in normolipidemic subjects.
- 社団法人日本循環器学会の論文
- 2002-01-20
著者
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Hamada Mareomi
Division of Cardiology, Uwajima City Hospital
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Funada Jun-ichi
Department of Cardiology, Ehime National Hospital
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Sekiya Michihito
Department of Cardiology, Ehime National Hospital
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Funada Jun-ichi
Department Of Cardiology Ehime National Hospital
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Hamada Mareomi
Second Department of Internal Medicine, Ehime University School of Medicine
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Hiwada Kunio
Second Department of Internal Medicine, Ehime University School of Medicine
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Sekiya Michihito
Department Of Cardiology Ehime National Hospital
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Sekita Michihito
Department Of Cardiology Ehime National Hospital
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Sekiya Michihito
Department Of Cardiology Ehime Hospital
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Hiwada Kunio
Second Department Of Internal Medicine Ehime University School Of Medicine
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Hiwada Kunio
The Second Department Of Internal Medicine Ehime University School Of Medicine Shigenobu The Departm
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Hayashi Makoto
Division Of Cardiology Uwajima City Hospital
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Sekiya Michihito
The 2nd Department Of Internal Medicine Ehime University School Of Medicine
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