Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Background: The interventricular septum in hypertrophic cardiomyopathy (HC) has a unique shape, which is characterized by the convex curvature toward the left ventricle (LV). The aim of this study was to examine the relationship between curvature of the LV wall and regional myocardial strain. Methods and Results: Fifty-six patients with HC (mean age, 55±12 years) and 20 age- and sex-matched control subjects (mean age, 56±8 years) were enrolled. The curvature index (1/radius) was measured by drawing along the endocardial surface from the apical 4-chamber and short axis views. Peak systolic strain was calculated in the septal and lateral walls using 2-D speckle tracking echocardiography. The septal curvature index and septal longitudinal strain were significantly lower in the HC group than in the control group. A multivariate model using the HC patient data showed that the septal curvature index and septal thickness were the independent determinants of septal longitudinal strain (septal curvature index: β=–0.421, P<0.001; septal thickness: β=0.401, P=0.002). In addition, global longitudinal strain and E/e' were worse in the lower septal curvature index group compared with the higher group. Conclusions: Septal longitudinal strain is associated with the degree of septal curvature. This indicates a possible link between LV wall configuration and regional myocardial function.
著者
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Yoshii Toyofumi
Department of Cardiology, Kitaishikai Hospital
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Shigematsu Yuji
Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate
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Higaki Jitsuo
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Funada Jun-ichi
Department Of Cardiology Ehime National Hospital
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Hiasa Go
Department Of Cardiology Kitaishikai Hospital
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Hamada Mareomi
Department Of Cardiology Uwajima City Hospital
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Sumimoto Takumi
Department Of Cardiology Kitaishikai Hospital
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Ogimoto Akiyoshi
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Suzuki Jun
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Nishimura Kazuhisa
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Nagai Takayuki
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Yoshii Toyofumi
Department Of Cardiology Kitaishikai Hospital
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Okayama Hideki
Department Of Cardiology Ehime Prefectural Central Hospital
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Saito Makoto
Department Of Bacteriology Aichi Prefectural Institute Of Public Health
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OKAYAMA Hideki
Department of Cardiology, Ehime Prefectural Central Hospital
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HIGAKI Jitsuo
Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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INOUE Katsuji
Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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NAGAI Takayuki
Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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Shigematsu Yuji
Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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