PE-529 Clinical Benefits of Distal Protection Using Filer Device on Functional Recovery at Risk Area in Patients With Acute Myocardial Infarction(Echo/Doppler(10)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
スポンサーリンク
概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2008-03-01
著者
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HIGAKI Jitsuo
Ehime University
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HIGAKI Jitsuo
Department of Integrated Medicine and Informatics, Ehime University Medical School
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OKAYAMA Hideki
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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INOUE Katsuji
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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Yoshii Toyofumi
Department of Cardiology, Kitaishikai Hospital
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Hiasa Go
Department of Cardiology, Kitaishikai Hospital
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Sumimoto Takumi
Department of Cardiology, Kitaishikai Hospital
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Saitoh Makoto
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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Nishimura Kazuhisa
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Suzuki Makoto
Kitaishikai Hospital
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Yamada Tadakatsu
Department of Cardiology, Kitaishikai Hospital
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Yamada Tadakatsu
Kitaishikai Hospital
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Hiasa Go
Department Of Cardiology Kitaishikai Hospital
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Inoue Katsuji
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Inoue Katsuji
Department Of Cardiology Saiseikai Saijo Hospital
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Higaki Jitsuro
The Department Of Geriatric Medicine Osaka University Medical School
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Okayama Hideki
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Sumimoto Takumi
Department Of Cardiology Kitaishikai Hospital
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Okayama Hideki
Division Of Cardiology Ehime University Graduate School Of Medicine
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Okayama Hideki
Department Of Cardiology Ehime University School Of Medicine
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Sumimoto Takumi
Department Of Cardiology Kitaishikai Hospital Ehime
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Higaki Jitsuo
Department Of Medicine And Geriatrics Osaka University Medical School
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Nishimura Kazuhisa
Division Of Cardiology Ehime University Graduate School Of Medicine
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Higaki Jitsuo
Department Of Geriatric Medicine Osaka University Medical School
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Okayama Hideki
Department Of Cardiology Kitaishikai Hospital
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Nishimura Kazuhisa
Department Of Cardiology Ehime Prefectural Imabari Hospital
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Yoshii Toyofumi
Department Of Cardiology Kitaishikai Hospital
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Sumimoto Takumi
Division Of Cardiology Kitaishikai Hospital
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Higaki Jitsuo
Department Of Ehime University Graduate School Of Medicine
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Saitoh Makoto
Department Of Applied Chemistry Faculty Of Engineering Osaka City University
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Okayama Hideki
Department Of Cardiology Ehime Prefectural Central Hospital
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Yamada Tadakatsu
Department Of Cardiology Hiroshima Prefectural Hospital
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Nishimura Kazuhisa
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Inoue Katsuji
Division Of Cardiology Department Of Integrated Medicine And Informatics Ehime University Graduate S
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Higaki Jitsuo
Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine, Japan
関連論文
- The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
- Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications : a sub-analysis of the CASE-J trial
- Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy
- Elevated Serum Uric Acid is an Independent Predictor for Cardiovascular Events in Patients With Severe Coronary Artery Stenosis : Subanalysis of the Japanese Coronary Artery Disease (JCAD) Study
- The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients
- FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me
- PJ-913 Radial strain as a possible parameter of the extent of the delayed-enhacement in patients with hypertrophic cardiomyopathy(MRI / MRA(04)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An
- OJ-117 The effect of cibenzoline in patients with hypertrophic obstructive cardiomyopathy-Insights from changes In left ventricular regional-temporal heterogeneity(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd Annual Scient
- OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific
- A985G Polymorphism of the Endothelin-2 Gene and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy
- FRS-024 Impact of Synergistic Polymorphisms in Adrenergic Receptor Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Me
- OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An
- OE-037 Combined Analysis of Polymorphisms in Inflammation-Related Genes and Their Effects on Atrial fibrillation in Patients with Dilated Cardiomyopathy(Arrhythmia, diagnosis/Pathophysiology/EPS(01)(A),Oral Presentation(English),The 72nd Annual Scientific
- OJ-014 Spotty Calcification Pattern of Culprit Coronary Artery Plaque is Associated with Lipid-rich Characteristics on IB-IVUS(OJ03,Intravascular Imagings (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- OE-094 The Effects of Pioglitazone on Postprandial Central Blood Pressure Regulation in Patients with Type 2 Diabetes Mellitus(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-310 Impaired Postprandial Vasodilatation in Metabolic Syndrome. On behalf of MEAL Investigators.(Diabetes/Obesity/Metabolic syndrome(06)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-121 Assessment of Relationship Between Calcification Pattern and Plaque Characteristics in Patients With Acute Coronary Syndrome : On Behalf of ATHLETE Investigators(Acute coronary syndrome, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annu
- Light Chain Deposition Disease Developing 15 Years Following the Diagnosis of Monoclonal Gammopathy of Undetermined Significance
- Hypertension Attenuates the Efficacy of Hypoglycemic Therapy for Preserving Coronary Flow Reserve in Patients with Type 2 Diabetes
- Plasma levels of inflammatory related substances are correlated with severity of aortic stiffness and endothelial dysfunction in hypertensive patients
- Plasma level of 8-hydroxydeoxyguanosine, a marker of oxidative stress, was correlated to endothelial dysfunction in hypertensive patients
- Serum hepatocyte growth factor concentration is a specific marker of endothelial dysfunction in humans
- Low-Dose Doxazosin Imoroved Aortic Stiffness and Endothelial Dysfunction as Measured by Noninvasive Evaluation
- A Family with Von Hippel-Lindau Disease Revealed by Pheochromocytoma
- Impairment of Instantaneous Autonomic Regulation Relates to Blood Pressure Fall Immediately after Standing in the Elderly and Hypertensives
- Influence of meal intake on pulse wave indices in type 2 diabetes
- PJ-616 Late Myocardial Enhancement at 64-Multislice Computed Tomography Compared with Magnetic Resonance Imaging(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-415 Quantification of Myocardial Strain of Left Ventricle Using Myocardial Tagging at 3.0T(PE070,CT/MRI (Myocardium) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-054 Standardized Coronary 64-slice CT Angiography Using the Diluted Contrast Medium : Single Center Study(DPE09,CT/MRI (Coronary/Vascular) (I),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-395 Clinical Significance of Non-invasive Measurements of Atherosclerosis in Patients with Effort Angina Pectoris(PJ067,Atherosclerosis (Clinical/Diagnosis) 3 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- PJ-083 Differentiation of Hypertrophic Cardiomyopathy from Hypertensive Heart Disease Using Two-Dimensional Strain Analysis(PJ014,Cardiomyopathy/Hypertrophy (Clinical) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circul
- PE-551 The Differences in Left Ventricular Twisting Behavior between Patients with Hypertensive Heart Disease and Hypertrophic Cardiomyopathy(PE092,Echo/Doppler (Myocardium) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- PE-548 Clinical Implication of Global Strain Rate during Isovolumic Relaxation Time in Patients with Non-ischemic Dilated Cardiomyopathy(PE092,Echo/Doppler (Myocardium) (I),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- PE-458 Significance of Decreased Subendocardial Radial Strain in Patients with Unstable Angina(PE077,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-114 A Novel Method for Measurement of Carotid Arterial Elastic Properties Using Two Dimensional Speckle Tracking Analysis(PE019,Echo/Doppler (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- OJ-221 Myocardial Fibrosis Attenuates the Effect of Cibenzoline on Left Ventricular Diastolic Function in Patients with Obstructive Hypertrophic Cardiomyopathy(OJ37,Echo/Doppler (Myocardium) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meet
- OE-130 A Link between Catenoid Shape Configuration of Hypertrophied Septum and Regional Myocardial Function in Patients with Hypertrophic Cardiomyopathy(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of T
- OE-127 Right Ventricular Septal Pacing Preserves Left Ventricular Synchrony and Torsional Behavior in Comparison with Conventional Apical Pacing(OE22,Echo/Doppler (Myocardium) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japan
- PJ-707 Left ventricular twisting behavior in patients with hypertension : Analysis by two dimensional speckle tracking method(Hypertension, clinical(09)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-704 Possible Link Between Left Ventricular Systolic and Diastolic Dyssynchrony and Diastolic Function in Patients With Essential Hypertension(Hypertension, clinical(09)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circ
- PJ-531 Chronic Kidney Disease is Associated with Impaired Coronary Flow Velocity Reserve(Kidney/Renal circulation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-418 A Novel Method for Measurement of Carotid Arterial Elastic Properties Using Two Dimensional Speckle Tracking Analysis(Atherosclerosis, clinical(11)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- PE-529 Clinical Benefits of Distal Protection Using Filer Device on Functional Recovery at Risk Area in Patients With Acute Myocardial Infarction(Echo/Doppler(10)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- Association between PPAR γ polymorphism and hypertension in Japanese
- Effects of Antihypertensive Drugs and Gene Variants in the Renin-Angiotensin System
- Lack of Correlation between Mbo I Restriction Fragment Length Polymorphism of Renin Gene and Essential Hypertension in Japanese
- Association of Polymorphism in the Promoter Region of the Apolipoprotein E Gene with Diastolic Blood Pressure in Normotensive Japanese
- Rationale, study design and implementation of the COLM study : the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients
- DPJ-044 Effect of Statin Therapy to Yellow Neointimal Formation Developed after Sirolimus-eluting Stent Implantation : Angioscopic Findings(DPJ08,Intravascular Imagings (I),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japane
- OJ-018 Different Patterns of Neointimal Formation 8 Months after Bare Metal Stent, Sirolimus, and Paclitaxel-eluting Stent Implantation : Angioscopic Findings(OJ03,Intravascular Imagings (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting
- Lack of Association between Genetic Polymorphism of CYP11B2 and Hypertension in Japanese: The Suita Study
- PE-566 The Plasma Osteopontin Level, both Full Length and Fragmented Form Elevated at the Vulnerable Plaque(PE095,Atherosclerosis (Clinical/Pathophysiology) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soci
- Quantification of Regional Myocardial Blood Flow Using First-Pass Multidetector-Row Computed Tomography and Adenosine Triphosphate in Coronary Artery Disease
- PJ-831 Quantification of Regional Myocardial Blood Flow using First-Pass Multidetector-row Computed Tomography and Adenosine Triphosphate in Coronary Artery Disease(CT / DSA(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
- 5 Current Status and Future Direction of Multi Detector-row Computed Tomography for the Integrated Management of Coronary Artery Disease(Symposium 14 (SY-14) (I) New Horizon of CT, MR and PET in Diagnostic Cardiac Imaging,Special Program,The 72nd Annual S
- Case of membranoproliferative glomerulonephritis due to essential cryoglobulinemia without hepatitis C virus infection
- PE-437 Plasma Osteopontin Level is a Predictor of Atherosclerosis in Patients with Essential Hypertension(Hypertension, clinical(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- A Case of Hyperreninemic Hypertension with Bilateral Positive Captopril Renography but without Renovascular Stenosis
- Relationship between Cardio-Ankle Vascular Index (CAVI) and Carotid Atherosclerosis in Patients with Essential Hypertension
- Myeloperoxidase antineutrophil cytoplasmic antibody-positive bronchiectasis in an elderly patient
- PE-442 C-Reactive Protein Predicts Recurrence of Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-441 Relationship between Matrix Metalloproteinases and Late Gadolinium-Enhancement with Cardiovascular Magnetic Resonance in Patients with Nonischemic Dilated Cardiomyopathy(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The
- 3 Serial Changes in Plaque Characteristics in Patients with Type 2 Diabetes Mellitus Using Integrated Backscatter Intravascular Ultrasound(Frontiers in Coronary Imaging,Symposium 15 (SY-15) (A),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- PE-188 Relationship between Peak Systolic Strain and Scintigraphic Myocardial Viability in Patients with Old Myocardial Infarction(Echo/Doppler(06)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-080 Clinical Advantage of Optimal Right Ventricular High Septal Pacing on Left Ventricular Dyssynchrony(Echo/Doppler(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-530 Advantages of 3.0T MRI Cardiac Imaging(MRI/MRA-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-080 A Link between Matrix Metalloproteinases in the Coronary Sinus and Left Ventricular Performance in Patients with Nonischemic Dilated Cardiomyopathy(OE14,Heart Failure (Biomarker) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- PJ-516 Sex Differences in the Relationship between G-protein Beta3 Subunit Gene C825T Polymorphism and Cardiovascular Events in Patients with Dilated Cardiomyopathy(Heart failure, clinical(18)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting
- PE-280 Relations of Serum Matrix Metalloproteinases in the Coronary Sinus to Left Ventricular Performance in Patients with Nonischemic Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting
- PE-092 A Link Between Plasma NT-proBNP in the Coronary Sinus and Left Ventricular Dyssynchrony in Patients with Nonischemic Dilated Cardiomyopathy(Heart failure, clinical(07)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Ci
- PE-045 Preventive Effect of Oral Ascorbic Acid on Attenuation of Coronary Flow Reserve by Nitrate Withdrawal.(Coronary circulation, basic/clinical(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-350 Assessment Of The Myocardial Perfusion Using MDCT(CT/DSA-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Angiotensin Receptor Blocker on Microalbuminuria and Adiponectin Concentration in Patients with Essential Hypertension(Hypertension, Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-079 Advanced Left Ventricular Dyssynchrony Influences on Neurohumoral Activation in Patients Receiving Right Ventricular Apical Pacing(Echo/Doppler(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
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- PJ-356 Effect of Right Ventricular Outflow Tract Pacing to Reduce Left Ventricular Dyssynchrony in Comparison with Right Ventricular Apical Pacing(Echo/Doppler-17, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-229 Acute Effect of Decrease in Wall Stress on Strain and Left Ventricle Twisting Motion Evaluated by 2D Speckle Tracking Imaging(Cardiac function, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-375 Vascular-Coronary Coupling : Large Artery Stiffness is a Determinant of Coronary Flow Velocity Reserve(Atherosclerosis, clinical-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-329 Intraventricular Dyssynchrony in Patients with Hypertrophic Cardiomyopathy is Associated with the Degree of Asymmetrical Septal Hypertrophy(Echo/Doppler-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-326 Right Ventricular Outflow Pacing Reduces Left Ventricular Asynchrony in Comparison with Conventional Apical Pacing(Echo/Doppler-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Bare metal stent implantation for in-stent restenosis with a drug-eluting stent
- OE-348 Coronary artery assessment and delayed contrast enhancement by 64-row multislice computed tomography in hypertrophic cardiomyopathy(CT/DSA(02)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-286 Frequency of Thrombus Formation after Sirolimus-eluting Stent Implantation. : Serial Angioscopic Study(Coronary revascularization, PCI(03)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-285 Relationship between Angioscopic Findings and Plaque Debris Collected by Aspiration and Filter Device after Saphenous Vein Graft Intervention.(Coronary revascularization, PCI(03)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of
- 3 Relationship between Plaque Surface Healing and Coronary Risk Factors and Medication in Patients after Sirolimus-Eluting Stent Implantation(Symposium 1 (SY-01) (IHD) Re-Evaluation of Drug Therapy in the DES Era,Special Program,The 72nd Annual Scientific
- PE-352 Difference Response of Plaque Surface between Bare Metal Stent and Sirolimus-eluting Stent 8 Months after Stent Implantation : Angioscopic Observations(Intravascular endoscopy/Intravascular ultrasound-5, The 71st Annual Scientific Meeting of the Ja
- PE-245 Frequency of Plaque Inflammatory Change after Sirolimus-Eluting Stent Implantation : Angioscopic findings(Intravascular endoscopy/Intravascular ultrasound-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-225 Usefulness of Automated Functional Imaging for Assessment of Left Ventricular Regional wall Motion in Patients with Myocardial Infarction(Echo/Doppler-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Visualization of traumatic tricuspid insufficiency by three-dimensional echocardiography
- A Japanese Patient With Cardiomyopathy Caused by a Novel Mutation R285X in the AGL Gene
- In vitro and in vivo therapeutic efficacy of the PPAR-γ agonist troglitazone in combination with cisplatin against malignant pleural mesothelioma cell growth
- Transmural Perfusion Gradient in Adenosine Triphosphate Stress Myocardial Perfusion Computed Tomography
- Right Ventricular Septal Pacing Preserves Global Left Ventricular Longitudinal Function in Comparison With Apical Pacing : Analysis of Speckle Tracking Echocardiography
- Association between cystatin C and inflammation in patients with essential hypertension
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Plasma thrombin-cleaved osteopontin elevation after carotid artery stenting in symptomatic ischemic stroke patients
- Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients With Dilated Cardiomyopathy
- Combination therapy for hypertension in the elderly : a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial