Use of Thallium-201 Myocardial Scintigraphy for the Prediction of the Response to ★-Blocker Therapy in Patients With Dilated Cardiomyopathy
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概要
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This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predict the usefulness of ★-blocker therapy in patients with dilated cardiomyopathy (DCM). Tl-201 and MIBG were performed in 47 patients before ★-blocker therapy. Patients were classified into group A, if their cardiac function improved, and group B, whose function remained unchanged. Two types of extent score (ES) by Tl-201 were proposed to quantitate myocardial damage, mean-2SD (ES-2) and mean-3SD (ES-3). The ES difference between ES-2 and ES-3 was calculated, and according to ES and ES difference, DCM cases were classified into 3 groups: mild-defect type (mild-type), moderate-defect type (moderate-type) and severe-defect type (severe-type). The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated, and the percent washout ratio of myocardial MIBG was obtained from these data. Group A comprised 18 mild-type, 14 moderate-type and 1 severe-type cases, and group B comprised 5 mild-type, 4 moderate-type and 5 severe-type cases. A significant relation was observed between the defect type on Tl-201 and the response to ★-blocker therapy (p=0.0090). Both H/M MIBG uptake ratios and washout ratio were not significantly different in the 2 groups. Tl-201 may be useful for predicting the response to ★-blocker therapy in patients with DCM.
- 社団法人日本循環器学会の論文
- 2002-11-20
著者
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Suzuki Jun
Second Department of Internal Medicine, Ehime University School of Medicine
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Ohtsuka Tomoaki
Second Department of Internal Medicine, Ehime University School of Medicine
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Shigematsu Yuji
Second Department of Internal Medicine, Ehime University School of Medicine
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Hara Yuji
The Second Department of Internal Medicine, Ehime University School of Medicine
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Hamada Mareomi
Division Of Cardiology Uwajima City Hospital
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Hara Yuji
Second Department of Internal Medicine, Ehime University School of Medicine
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Hamada Mareomi
Second Department of Internal Medicine, Ehime University School of Medicine
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Matsunaka Tsuyoshi
Ehime Prefectural Central Hospital
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Saeki Hideyuki
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
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Ogimoto Akiyoshi
Second Departement of Internal Medicine, Ehime University School of Medicine
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Nakata Shigeru
Department Of Radiology Ehime University School Of Medicine
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Matsunaka Tsuyoshi
Second Department of Internal Medicine, Ehime University School of Medicine
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Saeki Hideyuki
Second Department of Internal Medicine, Ehime University School of Medicine
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Matsunaka Tsuyoshi
Division Of Cardiology Ehime Central Prefectural Hospital
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