Attenuation of Biventricular Pressure Gradients by Cibenzoline in an 18-Year-Old Patient With Hypertrophic Obstructive Cardiomyopathy

概要

論文の詳細を見る
An 18-year-old male patient with biventricular hypertrophic obstructive cardiomyopathy (HOCM) had successful reduction of the pressure gradients by cibenzoline. At 11 months after birth, he was first diagnosed with cardiac murmurs and by the age of 5 years, he was diagnosed with subpulmonic infundibular stenosis with a pressure gradient of 10mmHg by cardiac catheterization. At the age of 14, re-catherterization revealed hypertrophic cardiomyopathy with isolated obstruction of the right ventricular outflow tract, with a pressure gradient of 70mmHg, but no obstruction in the left ventricle. He began daily treatment with 30mg propranolol. At the age of 18, he was admitted for cardiac evaluation. An echocardiogram revealed left mid-ventricular and subpulmonic obstructions associated with pressure gradients of 88mmHg and 65mmHg, respectively. A single oral dose of 200mg of cibenzoline decreased the pressure gradients in the left and right ventricles (38mmHg and 36mmHg, respectively). He was then given 300mg daily of cibenzoline, and both pressure gradients remained low without any complications 8months later at the time of discharge.
社団法人日本循環器学会の論文
2002-11-20