Augmented Secretion of Atrial and Brain Natriuretic Peptides During dynamic Exercise in Patients With Old Myocardial Infarction
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概要
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To assess the role of atrial and brain natriuretic peptides (ANP, BNP) in maintaining cardiac performance at rest and during exercise in patients with cardiac dysfunction, we measured plasma levels of ANP and BNP during ^<201>Tl dynamic exercise testing in 32 patients with angiographically proven old myocardial infarction (OMI) and 35 normal control subjects (CS). Plasma levels of ANP and BNP at rest were significantly higher in patients with OMI than in CS (AMP, 42.6±19.3 vs 19.4±2.4 pg/ml, p<0.01; BNP, 53.4±32.5 vs 2.8±0.8 pg/ml, p<0.01, respectively). Correlations were found between plasma levels of these peptides and left ventricular ejection fraction (LVEF), cardiac index (CI), pulmonary capillary wedge pressure (PCWP) and left ventricular end-diastolic pressure (LVEDP) in patients with OMI. In addition, a strong positive correlation was found between plasma levels of these peptides and the severity score obtained from ^<201>Tl myocardial scintigraphy. During exercise, both ANP and BNP significantly increased in patients with OMI. However, in CS, although ANP increased, BNP remained unchanged. The changes in plasma levels of ANP or BNP from at rest to peak exercise correlated with LVEF, CI, PCWP, LVEDP and the severity score in patients with OMI. These findings indicate that ANP and BNP play an important role in maintaining cardiac performance at rest and during exercise in patients with cardiac dysfunction.
- 社団法人日本循環器学会の論文
- 1995-10-20
著者
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Hiwada Kunio
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Hamada Mareomi
The Second Department of Internal Medicine, Ehime University School of Medicine
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Marumoto Kazumasa
The Second Department of Internal Medicine, Ehime University School of Medicine
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Hamada Mareomi
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Marumoto Kazumasa
The Second Department Of Internal Medicine Ehime University School Of Medicine
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Hayashi Makoto
Division Of Cardiology Uwajima City Hospital
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Aburaya Masahito
The Second Department of Internal Medicine, Ehime University School of Medicine
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Aburaya Masahito
The Second Department Of Internal Medicine Ehime University School Of Medicine
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