Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Insulin-like growth factor-1 (IGF- 1) is important in the hypertrophic response of the myocardium, so the present study was designed to elucidate whether the circulating levels of IGF- 1 and its binding proteins (IGFBPs) are related to the disease condition of patients with hypertrophic cardiomyopathy (HCM), in particular the occurrence of congestive heart failure (CHF). The study group comprised 124 patients with HCM and 15 healthy control subjects. The HCM patients were subdivided into 3 groups: 39 with hypertrophic obstructive cardiomyopathy (HOCM), 67 with hypertrophic non-obstructive cardiomyopathy (HNCM), and 18 with HCM and a history of CHF (HF-HCM, n=18). Serum levels of IGF-1 and IGFBPs (IGFBP-1 and -3) were compared between groups. IGF- 1 levels were significantly higher in patients with HOCM and HNCM, and lower in patients with HF-HCM than in control subjects (p<0.0001, p<0.005, and p<0.05, respectively). IGFBP-1 levels were significantly higher in patients with HF-HCM than in the other 3 groups (p<0.0001 for all). The findings suggest that circulating levels of IGF-1 and IGFBP-1 are related to the extent of myocardial injury in patients with HCM.
- 社団法人日本循環器学会の論文
- 2002-06-20
著者
-
Hiwada Kunio
The Second Department Of Internal Medicine Ehime University School Of Medicine
-
Hamada Mareomi
The Second Department of Internal Medicine, Ehime University School of Medicine
-
Hamada Mareomi
Division Of Cardiology Uwajima City Hospital
-
Saeki Hideyuki
Department Of Integrated Medicine And Informatics Ehime University Graduate School Of Medicine
-
Saeki Hideyuki
The Second Department of Internal Medicine, Ehime University School of Medicine
-
Hamada Mareomi
The Second Department Of Internal Medicine Ehime University School Of Medicine
-
Hiwada Kunio
The Second Department Of Internal Medicine Ehime University School Of Medicine Shigenobu The Departm
関連論文
- PE-439 Comparison of the Prognosis in Patients with Hypertrophic Obstructive Cardiomyopathy Between Before and After the Treatment with Antiarrhythmic Drug, Cibenzoline(PE074,Cardiomyopathy/Hypertrophy (Clinical) 2 (M),Poster Session (English),The 73rd An
- OJ-119 Synergistic Polymorphisms of Angiotensin Converting Enzyme and Endothelial Nitric Oxide Synthase and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(02)(M),Oral Presentation (Japanese),The 72nd An
- A985G Polymorphism of the Endothelin-2 Gene and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy
- Effect of Intravenous Administration of Cibenzoline on Left Ventricular Diastolic Pressures in Patients With Hypertrophic Cardiomyopathy : Its Relationship to Transmitral Doppler Flow Profiles
- Antiarrhythmic Drug Cibenzoline Attenuates Left Ventricular Pressure Gradient and Improves Transmitral Doppler Flow Pattern in Patients With Hypertrophic Obstructive Cardiomyopathy Caused by Midventricular Obstruction
- 17-Year Follow-up Study of a Patient With Obstructive Hypertrophic Cardiomyopathy With a Deletion Mutation in the Cardiac Myosin Binding Protein C Gene
- CLINICAL SIGNIFICANCE OF SYSTOLIC TIME INTERVALS IN DETECTING THE STENOSIS OF PROXIMAL LEFT CORONARY ARTERY : Ischemic Heart Disease (V) : FREE COMMUNICATIONS (V) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DIFFERENCE IN MYOCARDIAL CHARACTERISTICS BETWEEN HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL HYPERTROPHY DUE TOESSENTIAL HYPERTENSION
- NONINVASIVE EVALUATION OF LEFT VENTRICULAR FUNCTION BY SYSTOLIC TIME INTERVALS IN ESSENTIAL HYPERTENSION WITH ANGINA PECTORIS
- CALCIUM-CHANNEL BLOCKERS AND BETA-ADRENERGIC BLOCKER : THE DIFFERENCE EFFECTS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- CLINICAL SIGNIFICANCE OF SYSTOLIC TIME INTERVALS FOR THE EVALUATION OF LEFT VENTRICULAR FUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE
- DIAGNOSTIC SIGNIFICANCE OF EARLY DIASTOLIC TIME INTERVALS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL HYPERTROPHY DUE TO ESSENTIAL HYPERTENSION
- IS CAPTOPRIL EFFECTIVE IN PRIMARY PULMONARY HYPERTENSION?
- OJ-221 Myocardial Fibrosis Attenuates the Effect of Cibenzoline on Left Ventricular Diastolic Function in Patients with Obstructive Hypertrophic Cardiomyopathy(OJ37,Echo/Doppler (Myocardium) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meet
- PJ-424 Metabolic Syndrome Deteriorates Coronary Microcirculation and Clinical Outcome in Patients with Acute Myocardial Infarction(Atherosclerosis, clinical-11, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-407 Safety and Efficacy of Sirolimus Eluting Stent Implantation Following Coronary Debulking : Comparison with Bare Metal Stent(Coronary revascularization, PCI-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-231 Is Focal Spasm Associated with Vulnerable Atherosclerosis Development?(Acute coronary syndrome, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-092 Relationship between Metabolic Abnormality and Cardiac Perfusion in Patients with Hypertension(Hypertension, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-369 Effect of Sarpogrelate Hydrochloride on Coronary Circulation and Ischemia-reperfusion Injury after Percutaneous Coronary Intervention(Coronary revascularization, PCI-17 (IHD) PJ62,Poster Session (Japanese),The 70th Anniversary Annual Scientific Mee
- PJ-289 Lipoprotein Profile Predicts Plaque Vulnerability in Patients with ACS : Evaluation by Virtual Histology IVUS(Acute coronary syndrome, basic/clinical-6 (IHD) PJ49,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- PJ-234 1-year Follow Up of Drug Eluting Stent (Cypher^)(Intravascular endoscopy/Intravascular ultrasound-5 (I) PJ39,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-215 Relation to Diastolic Peak Velocity and B-type Natriuretic Peptide in Patients with Non-ischemic Heart Failure(Heart failure, clinical-16 (M) PJ36,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- PE-407 Comparative Effects of Valsaltan versus Amlodipine on Insulin Resistance, Chronic Inflammation, and Arterial Stiffness in Hypertensive Patients with Metabolic Syndrome(Hypertension, clinical-6 (H) PE68,Poster Session (English),The 70th Anniversary
- Antiarrhythmic Drug, Cibenzoline, can Directly Improve the Left Ventricular Diastolic Function in Patients With Hypertrophic Cardiomyopathy
- Ischemia in the Territory of the First Major Septal Perforator Branch Anomalously Originating From the First Diagonal Branch Leads to a Transient Leftward Shift of the QRS Axis in the Frontal Plane
- Effect of Beta-Blocker on Left Ventricular Function and Natriuretic Peptides in Patients With Chronic Heart Failure Treated With Angiotensin-Converting Enzyme Inhibitor
- Apical Hypertrophic Cardiomyopathy Associated With Life-Threatening Paroxysmal Atrial Flutter With a Slow Ventricular Response : A Case Report
- Warfarin-Induced Eosinophilic Pleurisy
- -P261- INTRACAVITARY FILLING PATTERN IN THE FAILING LEFT VENTRICLE ASSESSED BY INTRA VENOUS INJECTION OF SONICATED ALBUMIN(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Ubenimex Activates the E-Cadherin-mediated Adhesion of a Breast Cancer Cell Line YMB-S
- Severe Inclusion Body Myositis with Interstitial Pneumonia
- Increased Circulating Soluble Form of Fas in Patients With Dilated Cardiomyopathy
- IMPACT OF A FAMILY HISTORY OF HYPERTENSION ON BLOOD PRESSURE LEVELS DURING EARLY AND LATE ADOLESCENCE
- The Unique 5'-Flanking Region of the Human Basic Calponin Gene
- -P189- ALTERNATION OF THE GENES ENCODING SARCOPLASMIC RETICULUM PROTEINS IN DIABETIC-RAT HEART(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -P213- A NOVEL CALMODULIN- AND F-ACTINBINDING PROTEIN IN VERTEBRATE SMOOTH MUSCLE
- Human Angiotensin Converting Enzyme : Immunological Property and Localization : THE 11th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Left Ventricular Geometry and Cardiac Function in Mild to Moderate Essential Hypertension
- Activation and Molecular Weight Changes of Human Plasma Inactive Renin by Proteolytic Enzymes : The 12th Conference on the Pathogenesis of Hypertension
- Assessment of Microvascular Integrity by Intravenous Myocardial Contrast Echocardiography in Patients With Hypertrophic Cardiomyopathy
- Association of Monocyte Chemoattractant Protein 1 (MCP-1) Gene Polymorphism With Susceptibility to Dilated Cardiomyopathy
- Circulating levels of insulin-like growth factor-I and its binding proteins in patients with hypertrophic cardiomyopathy
- Relation Between Angiotensin-Converting Enzyme II Genotype and Atrial Fibrillation in Japanese Patients With Hypertrophic Cardiomyopathy
- Insulin resistance and tumor necrosis factor- α in patients with dilated cardiomyopathy : effect of beta-blocker
- Relationship between insulin resistance and coronary endothelium-dependent vasodilation in essential hypertension
- Tumor necrosis factor-alpha and matrix metalloproteinase activity in patients with idiopathic dilated cardiomyopathy
- Increased Circulating Levels of Procollagen Peptides in Patients with Hypertrophic Cardiomyopathy
- Effect of carvedilol on cardiac matrix remodeling in patients with idiopathic dilated cardiomyopathy
- Ten-year follow-up study of thallium-201 myocardial scintigraphy in 104 patients with hypertrophic cardiomyopathy
- Attenuation of Biventricular Pressure Gradients by Cibenzoline in an 18-Year-Old Patient With Hypertrophic Obstructive Cardiomyopathy
- Circulating Levels of Insulin-Like Growth Factor-1 and Its Binding Proteins in Patients With Hypertrophic Cardiomyopathy
- Serum cystatin C and target organ damage in patients with essential hypertension
- 10-YEAR FOLLOW-UP OF YOUNG MALE PATIENTS WITH MILD HYPERTENSION
- LONG TERM FOLLOW-UP OF YOUNG MALES WITH MILD HYPERTENSION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
- Direct Radioimmunoassay for Human Renin Substrate and its Measurement in Plasma from Essential Hypertensive Patients, Diabetic Patients and Pregnant Women : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- Distal Acinar Emphysema and Interstitial Pneumonia in a Patient with von Recklinghausen's Disease : Five-Year Obsevation Following Quitting Smoking
- Near-Death Asthmatic Reaction Induced by Disodium Cromoglycate
- Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy
- A STUDY OF CARDIAC FUNCTION IN THE DIABETICS : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Relationship between Myocardial Fibrosis Using Gadolinium-DTPA Enhanced Magnetic Resonance Imaging and Left Ventricular Function in Hypertrophic Cardiomyopathy
- -0453- HETEROGENEITY OF VASODILATOR RESPONSE TO ACETYLCHOLINE AND ATP IN CORONARY AND RENAL ARTERIES(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1234- TARGET ORGAN DAMAGE IN PRIMARY ALDOSTERONISM : COMPARISON WITH ESSENTIAL HYPERTENSION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1055- ESTIMATION OF SYSTOLIC PULMONARY ARTERY PRESSURE BY A THALLIUM-201 MYOCARDIAL IMAGING IN PATIENTS WITH RIGHT VENTRICULAR OVERLOAD(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Mechanism of Atrial Fibrillation and Increased Incidence of Thromboembolism in Patients With Hypertrophic Cardiomyopathy
- HEMODYNAMIC CHARACTERISTICS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY WHO HAVE A HISTORY OF SYNCOPE
- LEFT VENTRICULAR ADAPTATION TO HYPERTENSION AND EXTRACARDIAC TARGET ORGAN DAMAGE
- Eotaxin Levels in Pleural Effusions: Comparison with Monocyte Chemoattractant Protein-1 and IL-8
- IgG and IgM Rheumatoid Factor Levels Parallel Interleukin-6 during the Vasculitic Phase in a Patient with Churg-Strauss Syndrome
- Effect of Beta-Blocker Therapy in Elderly Patients With Dilated Cardiomyopathy
- Subendocardial Microvasucular Abnormalities in Patients with Hypertrophic Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography
- Contribution of Genetic Predispositions to Hypertension to Left Ventricular Hypertrophy Is Mediated by Insulin Resistance
- Aortic Compliance in Essential Hypertension Is Associated with Insulin Resistance Metabolic Syndrome
- Guidelines for Hypertension in the Elderly : 1999 Revised Version
- MORPHOLOGICAL AND FUNCTIONAL IDENTIFICATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY ESTIMATED BY LEFT VENTRICULOGRAM AT THE RIGHT ANTERIOR OBLIQUE PROJECTION : Cardiomyopathy (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CI
- AORTIC VALVULAR DISEASE AND RIGHT CORONARY ARTERY STENOSIS INDUCED BY MEDIASTINAL IRRADIATION : Report of a Case
- EFFECT OF L-THREO-3, 4-DIHYDROXYPHENYLSERINE ON ORTHOSTATIC HYPOTENSION IN A PATIENT WITH SPINAL CORD INJURY
- Augmented Secretion of Atrial and Brain Natriuretic Peptides During dynamic Exercise in Patients With Old Myocardial Infarction
- First-pass Myocardial Perfusion Defect and Delayed Contrast Enhancement in Hypertrophic Cardiomyopathy Assessed with MRI
- Relationship between Renin Profile and Coronary Endothelium-Dependent Vasodilation in Essential Hypertension
- Brain Natriuretic Peptide Level Can Differentiate Patients with Essential Hypertension from Patients with Hypertensive Hypertrophic Cardiomyopathy
- Myocardial Structural Abnormalities Contribute to Left Ventricular Enlargement and Dysfunction in Patients with Dilated Cardiomyopathy ; Usefulness of Ultrasonic Tissue Characterization
- Long-Term Effects of Carvedilol Versus Metoprolol on Left Ventricular Function, Remodeling and Neurohumoral Factors in Patients with Idiopathic Dilated Cardiomyopathy
- Microvascular Damage Contributes to the Left Ventricular Dysfunction in Patients with Idiopathic Dilated Cardiomyopathy : Usefulness of Intravenous Myocardial Contrast Echocardiography
- Relationship between Circulating Interleukin-13 and Left Ventricular Remodeling in Patients with Idiopathic Dilated Cardiomyopathy
- Relation between Angiotensin-Converting Enzyme II Genotype and Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy
- Heart Failure Is the Highest Incidence of Cardiovascular Events and Deaths in Patients with Hypertrophic Cardiomyopathy : A 14-Year Follow-Up Study
- An Adult Case with Multiple Cardiac Valve Prolapse and Regurgitation
- Effects of Angiotensin II, Thyroxine and Estrogen on Plasma Renin Substrate Concentration and Renin Substrate Production by the Liver : THE 10th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- SYSTOLIC ANTERIOR MOTION OF THE MITRAL VALVE ASSOCIATED WITH ACUTE MYOCARDIAL INFARCTION IN A 62-YEAR-OLD PATIENT
- Cardiomyocyte Functions Couple with Left Ventricular Geometric Patterns in Hypertension
- MORPHOLOGICAL CHARACTERISTICS OF HYPERTROPHIC CARDIOMYOPATHY ESTIMATED BY LEFT VENTRICULOGRAPHY
- Effects of Coronary Blood Flow on Left Ventricular Function in Essential Hypertensive Patients
- Ischemic Preconditioning and Lipopolysaccharide Attenuate Nuclear Factor-κB Activation and Gene Expression of Inflammatory Cytokines in the Ischemia : Reperfused Rat Heart
- Myocardial Ischemia Induced by Anomalous Aortic Origin of the Right Coronary Artery in a Patient with Atrial Septal Defect
- Drug Eruption Caused by Recombinant Human G-CSF
- Left Ventricular End-Systolic Wall Stress is a Potent Prognostic Variable in Patients With Dilated Cardiomyopathy
- Hypoglycemic Syncope Induced by a Combination of Cibenzoline and Angiotensin Converting Enzyme Inhibitor.
- Rapid Progression of Primary Cardiac Leiomyosarcoma with Obstruction of the Left Ventricular Outflow Tract and Mitral Stenosis
- Fatal Pulmonary Hypertension in a Patient with Mixed Connective Tissue Disease: Report of an Autopsy Case.
- Congenitally Corrected Transposition of the Great Arteries in a 65-Year-Old Woman.