Abnormal Fatty Acid Composition of Lymphocytes of Biotin-Deficient Rats.
スポンサーリンク
概要
- 論文の詳細を見る
The relative proportions (% of total fatty acids) of odd-chain (15:0-29:0) and long-chain (22:0-30:0) saturated fatty acids in phospholipids of biotin-deficient rat lymphocytes were significantly in-creased as compared with biotin-supplemented rats, and the ratio of unsaturated fatty acids to saturated fatty acids in the former was signifi-cantly decreased mainly due to the reduced composition of poly-unsaturated fatty acids in the ω-3, ω-6, and ω-9 pathway. The ratio of cis-vaccenic acid to palmitoleic acid in biotin-deficient rats was signifi-cantly lower than that in control rats, and was thought to be another important, but previously unreported indicator of biotin deficiency. These changes imply that the elongation and desaturation of unsaturated fatty acids are depressed in lymphocytes of biotin-deficient rats, and may contribute to the associated immunological dysfunction in biotin deficien-cy through abnormal prostaglandin metabolism and/or cell membrane functions.
- 財団法人 学会誌刊行センターの論文
著者
-
KIKAWA Yoshiharu
Department of Pediatrics, Fukui Medical School
-
SUDO MASAKATSU
Department of Pediatrics, Fukui Medical School
-
Kikawa Yoshiharu
Department Of Pediatrics Fukui Medical School
-
Nakai Akio
Department Of Neurology And Neurosurgery Montreal Neurological Institute And Hospital Mcgill Univers
-
Sudo Masakatsu
Department Of Pediatrics Fukui Medical School
-
Shigematsu Yosuke
Department Of Fundamental Nursing Fukui Medical University
-
Liu Yuan
Department Of Catalysis Sciences And Technology School Of Chemical Engineering Tianjin University
-
LIU Yuan
Department of Pediatrics, Fukui Medical School
-
BYKOV Igor
Department of Pediatrics, Fukui Medical School
-
FUKUI Tohru
Byoutai-Seiri Laboratory
関連論文
- Bone-inducing ability of lyophilized periosteum (dura mater) with rhBMP-2 and TGF-β
- Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry
- Rapid, simplified and sensitive method for screening fructose-1, 6-diphosphatase deficiency by analyzing urinary metabolites in urease/direct preparations and gas chromatography-mass spectrometry in the selected-ion monitoring mode
- Enzymatic diagnosis of medium-chain acyl-CoA dehydrogenase deficiency by detecting 2-octenoyl-CoA production using high-performance liquid chromatography : A practical confirmatory test for tandem mass spectrometry newborn screening in Japan
- Bone mineral status in ambulatory pediatric patients on long-term anti-epileptic drug therapy
- Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease
- Evaluation of a rapid reagent strip test for the diagnosis of childhood meningitis
- Ultrasonography for the detection of ureteric reflux in infants with urinary infection
- Measurement of urinary fibrin/fibrinogen degradation products revisited and re-emphasized
- III B21 Hippocampal a-[^C]methyl-L-tryptophan uptake negatively correlates with glucose metabolism in patients with intractable temporal lobe epilepsy
- A Case of Female Pseudohermaphroditism Caused by Aromatase Deficiency
- Urinary oxidative stress markers in young patients with type 1 diabetes
- Anti-hyperglycemic Effect of Fangchinoline Isolated from Stephania Tetrandra Radix in Streptozotocin-Diabetic Mice
- Identification of a Response Element for Vitamin D3 and Retinoic Acid in the Promoter Region of the Human Fructose-1,6-bisphosphatase Gene^1
- Modifications in electrospray tandem mass spectrometry for a neonatal-screening pilot study in Japan
- Protective Effects of Toki-Shakuyaku-San Tsumra Japan-23(TJ-23)on β-Amyloid Protein(β40)-induced Apoptosis in Pheochromocytoma-12(PC12)Cells
- Eco-friendly Synthesis of m-Tolunitrile by Heterogeneously Catalysed Liquid Phase Ammoxidation
- Development of antigen-specific IgE antibodies in atopic and non-atopic infants : Diagnostic value of low levels of IgE against egg white in infants with atopic dermatitis
- Intravenous glycerol therapy should not be used in patients with unrecognized fructose-1, 6-bisphosphatase deficiency
- A novel, quantitative assay for homocarnosine in cerebrospinal fluid using stable-isotope dilution liquid chromatography-tandem mass spectrometry
- Left renal pelvis of male neonates is predisposed to dilatation
- Urine microscopy on a counting chamber for diagnosis of urinary infection
- Stable-isotope dilution gas chromatography-mass spectrometric measurement of 3-hydroxyglutaric acid, glutaric acid and related metabolites in body fluids of patients with glutaric aciduria type 1 found in newborn screening
- -0869- Electrocaradiography with intravenous dipyridamole in patients of coronary artery stenosis complicating with Kawasaki disease. Alteration of the QRS amplitude as the means for diagnosis.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPA
- Characterization of Glycoside Hydrolase Family 6 Enzymes from Coprinopsis cinerea
- Molecular analysis of a presymptomatic case of carnitine palmitoyl transferase I (CPT I) deficiency detected by tandem mass spectrometry newborn screening in Japan
- Relationships of anatomical characteristics versus shrinkage and collapse properties in plantation-grown eucalypt wood from China
- Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder
- Highly Active and Selective Nickel-Cerium(IV) Oxide Catalyst for Water-Gas Shift Reaction
- Upregulation of IRS-1 Expression in Goto-Kakizaki Rats Following Roux-en-Y Gastric Bypass Surgery : Resolution of Type 2 Diabetes?
- Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation
- Treatment of idiopathic pituitary dwarfism with methionyl human growth hormone.
- A case of intracranial saccular aneurysm after primary varicella zoster virus infection
- Abnormal Fatty Acid Composition of Lymphocytes of Biotin-Deficient Rats.