Prevention of adrenaline-induced pulmonary edema in rabbits with sodium nitroprusside.
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概要
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The effect of sodium nitroprusside on adrenaline-induced pulmonary edema was studied.<BR>Pulmonary edema was induced in rabbits by intravenous infusion of adrenaline. The marked hemodynamic changes observed were: rise in systemic arterial pressure, reduction of left ventricular output, reduction of renal blood flow, elevation of left atrial pressure, and increase of pulmonary blood volume. When sodium nitroprusside was injected about 1 min after the start of the adrenaline infusion, the hemodynamic changes were suppressed or reversed, and pulmonary edema was prevented very effectively. However, maintenance of the renal blood flow was inadequate.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Nagaoka Hideo
Department Of Cardiovascular Surgery Tsuchiura General Hospital
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Yamamoto Norio
Department Of Applied Mathematics Faculty Of Engineering Tokushima University
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Yamada Takashi
Department Of Animal Science Graduate School Of Agricultural Science Kobe University
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MINESHITA Satoru
Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
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YAMAMOTO Norio
Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
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