The pharmacokinetics of tobramycin in the elderly above 80 years old.
スポンサーリンク
概要
- 論文の詳細を見る
The pharmacokinetics of tobramycin were studied in two groups of elderly people. Sixteen aged people (65-97 years old) participated in the study after giving informed verbal consent. They were divided into two groups: group I consisted of the age group 65-79, and group II consisted of 80-97 years old.<BR>Tobramycin was administered intravenously with an infusion pump over lhr. Blood samples (3 ml) were collected at 7 time points via an indwelling catheter placed in the forearm. Serum creatinine, beta-2-microglobulin, and tobramycin concentrations weremeasured. The values obtained were compared between the two groups. Serum creatinine showed no significant differences in the 2 groups, whereas beta-2-microglobulin was significantly higher in group II (3. 35 ± 0.95) than in group I (2.25 ± 0.48). The elimination rate constant of tobramycin was determined from 7 postinfusion serum concentrations using linear regression on a natural logarithm concentration-versus-time graph. Half-life was calculated by dividing the elimination rate constant into 0.693. The half-lives of these 2 groups were 2.5± 0.47 (hr) and 4.2± 1.2 (hr) respectively and they were significantly different. The serum beta-2-microglobulin concentration correlated with the half-life of this drug in all subjects. Due to the large degree of interpatient variability observed, individualization of tobramycin doses using serum concentration monitoring may help to rapidly achieve desired steady-state levels.
- 一般社団法人 日本臨床薬理学会の論文
著者
-
Honda Yumiko
Department Of Physics Faculty Of Science Ochanomizu University
-
MINESHITA Satoru
Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
-
TAKANO Kikuo
Department of Medicine, Juntendo University, School of Medicine
-
TAKANO Kikuo
Department of Geriatrics, Sohsen Hospital
-
HONDA Yumiko
Department of Medicine, Aoyama Kyosai Hospital
関連論文
- Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations
- Use of salivary acetaminophen concentration to assess gastric emptying rate of liquids
- Intestinal Behcet's disease associated with non-Hodgkin's lymphoma
- Pulmonary Edema Induced by Angiotensin II in Rats
- The Effect of the Prostaglandin I_2 Analogue OP-2507 on Adrenaline-Induced Pulmonary Edema in Rabbits and Analysis of Hemodynamic Changes
- Pulmonary Edema Induced by Angiotensin I in Rats
- The Role of an Uncommon Type of Oral Streptococcus Sanguis in the Etiology of Befcet's Disease
- Contractile and Extensile Effects of Red and White Wine on Rat and Mongolian gerbil Gastrointestinal Smooth Muscle
- Motion of a Charged Particle in an Electromagnetic Field
- Role of Endothelin-1/Endothelin Receptor System in Endotoxic Shock Rats
- Basic study on serial changes in serum element concentrations and the effects of diet
- A Case Report of Ivermectin-Induced Prolonged Liver Dysfunction in an Elderly Patient with Scabies
- Simultaneous HPLC Determination of Acetaminophen and Four of Its Major Metabolites in Small-Volume Biologic Fluids.
- Age difference in kinetics of diazepam and lorazepam in man.
- The pharmacokinetics of tobramycin in the elderly above 80 years old.
- Pharmacokinetics of phenacetin in phenacetin abusers.
- A Proposed Formula to Estimate Creatinine Clearance from Serum Albumin Concentration in Debilitated Elderly.
- Pharmacokinetic Study of Aspirin in Gastrectomized Patients.
- Determination of phenacetin and its matabolites in human urine and plasma by high-performance liquid chromatography.
- Prevention of adrenaline-induced pulmonary edema in rabbits with sodium nitroprusside.