Effects of Candesartan and Probucol on Restenosis After Coronary Stenting : Results of Insight of Stent Intimal Hyperplasia Inhibition by New Angiotensin II Receptor Antagonist (ISHIN) Trial
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to determine whether candesartan and its combination with probucol reduce restenosis after coronary stenting. A total of 132 patients who successfully underwent stenting were randomly assigned to a control group (n=45), a candesartan group (8 mg daily, n=43), or a candesartan plus probucol group (+ probucol 500mg daily, n=44). No differences in late loss were observed between the control and candesartan groups. In the candesartan plus probucol group, late loss was significantly smaller than in the control and candesartan groups (p=0.003,0.015). The restenosis rate was 27% in the control group, 26% in the candesartan group (p>0.99), and 11% in the candesartan plus probucol group (p=0.104 vs the control group and p=0.103 vs the candesartan group). Intravascular ultrasound revealed no differences in stent area among the 3 groups, and no differences in lumen area or in intimal hyperplasia area between the control and candesartan groups. However, the intimal hyperplasia area in the candesartan plus probucol group was significantly less than that in the control and candesartan groups (p<0.001, p<0.001). This study demonstrated that candesartan failed to inhibit the neointimal hyperplasia and although the combination treatment did reduce neointimal hyperplasia, it did not statistically reduce the restenosis rate. (Circ J 2003; 67: 519-524)
- 社団法人日本循環器学会の論文
- 2003-05-20
著者
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Takaki Akira
Division of Cardiology, Tokuyama Central Hospital
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Ogawa Hiroshi
Division of Cardiology, Tokuyama Central Hospital
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Wakeyama Takatoshi
Division of Cardiology, Tokuyama Central Hospital
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Iwami Takahiro
Division of Cardiology, Tokuyama Central Hospital
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Iida Hiroshi
Division of Gastroenterology, Yokohama City University Graduate School of Medicine
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Tanaka Takeo
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Iida Hiroshi
Division Of Cardiology Tokuyama Central Hospital
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Ogawa Hiroshi
Division Of Cardiology Tokuyama Central Hospital
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Wakeyama Takatoshi
Division Of Cardiology Tokuyama Central Hospital
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Iwami Takahiro
Division Of Cardiology Tokuyama Central Hospital
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Mochizuki Mamoru
Division of Cardiology, Tokuyama Central Hospital
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Iwami Takahiro
Tokuyama Central Hospital
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Tanaka Takeo
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Takaki Akira
Division Of Cardiology Tokuyama Central Hospital
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Tanaka Takeo
Department Of Medicine And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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TAKAKI Akira
Takaki Medical Clinic
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Ogawa H.
Yamaguchi University School of Medicine
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Iwamoto Hiroshi
Division Of Cardiology Tokuyama Central Hospital
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Mochizuki Mamoru
Division Of Cardiology Tokuyama Central Hospital
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Mochizuki Mamoru
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Tanaka Takeo
Divison Of Cardiology Tokuyama Central Hospital
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Iwami Takahiro
The Division Of Cardiology Tokuyama Central Hospital
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Mochizuki Mamoru
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Mochizuki Mamoru
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Mochizuki Mamoru
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
-
Mochizuki Mamoru
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Tanaka Takeo
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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