Synthesis of Saframycins. VIII. Synthesis of the ABC Ring of Safracins
スポンサーリンク
概要
- 論文の詳細を見る
An efficient synthesis of the 1,5-imino-3-benzazocine derivative (18) from 1,4-diacetyl-2,5-piperazinedione (7) and 4-methoxy-3-methylbenzaldehyde (8) is described. The tricyclic lactam (18) is shown to be a useful intermediate for preparation of a phenol (5), which has the structure of the ABC ring system of safracins and ecteinascidins. This conversion is a promising route to total synthesis of (±)-safracin A (1a).
- 社団法人日本薬学会の論文
- 1992-10-25
著者
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齋藤 直樹
Meiji Pharmaceutical University
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久保 陽徳
明治薬科大学
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久保 陽徳
Meiji College of Pharmacy
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尾原 靖子
Meiji College of Pharmacy
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東谷 正子
Meiji College of Pharmacy
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Kubo Akinori
Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical University
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